Sunit Das

MD, PhD, MA, BA

Scientist, Keenan Research Centre for Biomedical Science

Biography

Dr. Sunit Das is a Scientist in the Keenan Research Centre for Biomedical Science and neurosurgeon at St.Michael’s Hospital. He is an Assistant Professor in the Department of Surgery at the University of Toronto. Dr. Das studied English Literature at the University of Michigan and Philosophy at Harvard University before moving to Chicago for medical school at Northwestern University. He completed a Doctor of Philosophy at the National Institutes of Health, where he studied the molecular processes that underly adult neurogenesis in the lab of Dr. ZuHang Sheng. He returned to Chicago for his neurosurgical residency, during which time he also began work on cancer stem cells in primary brain tumours in the lab of Dr. John Kessler. He was recruited to the University of Toronto in 2010. Dr. Das’s clinical practice and clinical research focus of the treatment of patients with tumours of the brain and spine. His laboratory at the Hospital for SickKids focuses on non-coding RNA and control of cell identity in glioblastoma and neural stem cells. He is a member of the Arthur and Sonia Labatt Brain Tumour Research Centre at the Hospital for Sick Children, and faculty with the Institute of Medical Science and Department of Laboratory Medicine and Pathobiology.

Recent Publications

  1. Das, S. The ethics of neuro-oncology in the era of COVID-19: Lessons to be learned. Neuro-oncology. 2020; :. doi: 10.1093/neuonc/noaa134. PubMed PMID:32470110 .
  2. Katz, L, Woolman, M, Talbot, F, Amara-Belgadi, S, Wu, M, Tortorella, S et al.. Dual Laser and Desorption Electrospray Ionization Mass Spectrometry Imaging Using the Same Interface. Anal. Chem. 2020;92 (9):6349-6357. doi: 10.1021/acs.analchem.9b05340. PubMed PMID:32275820 .
  3. Erickson, AW, Brastianos, PK, Das, S. Assessment of Effectiveness and Safety of Osimertinib for Patients With Intracranial Metastatic Disease: A Systematic Review and Meta-analysis. JAMA Netw Open. 2020;3 (3):e201617. doi: 10.1001/jamanetworkopen.2020.1617. PubMed PMID:32211870 PubMed Central PMC7097701.
  4. Das, S, Sahgal, A, Perry, JR. Commentary: Lomustine-temozolomide combination therapy versus standard temozolomide therapy in patients with newly diagnosed glioblastoma with methylated MGMT promoter (CeTeG/NOA-09): a randomised, open-label, phase 3 trial. Front Oncol. 2020;10 :66. doi: 10.3389/fonc.2020.00066. PubMed PMID:32083011 PubMed Central PMC7005933.
  5. Faruqi, S, Ruschin, M, Soliman, H, Myrehaug, S, Zeng, KL, Husain, Z et al.. Adverse Radiation Effect After Hypofractionated Stereotactic Radiosurgery in 5 Daily Fractions for Surgical Cavities and Intact Brain Metastases. Int. J. Radiat. Oncol. Biol. Phys. 2020;106 (4):772-779. doi: 10.1016/j.ijrobp.2019.12.002. PubMed PMID:31928848 .
  6. Rigamonti, A, Garavaglia, MM, Ma, K, Crescini, C, Mistry, N, Thorpe, K et al.. Effect of bilateral scalp nerve blocks on postoperative pain and discharge times in patients undergoing supratentorial craniotomy and general anesthesia: a randomized-controlled trial. Can J Anaesth. 2020;67 (4):452-461. doi: 10.1007/s12630-019-01558-7. PubMed PMID:31879855 .
  7. Brenna, C, Das, S. Imperfect by design: the problematic ethics of surgical training. J Med Ethics. 2019; :. doi: 10.1136/medethics-2019-105837. PubMed PMID:31836623 .
  8. Kaka, N, Hafazalla, K, Samawi, H, Simpkin, A, Perry, J, Sahgal, A et al.. Progression-Free but No Overall Survival Benefit for Adult Patients with Bevacizumab Therapy for the Treatment of Newly Diagnosed Glioblastoma: A Systematic Review and Meta-Analysis. Cancers (Basel). 2019;11 (11):. doi: 10.3390/cancers11111723. PubMed PMID:31689995 PubMed Central PMC6895972.
  9. Sachdeva, R, Wu, M, Johnson, K, Kim, H, Celebre, A, Shahzad, U et al.. BMP signaling mediates glioma stem cell quiescence and confers treatment resistance in glioblastoma. Sci Rep. 2019;9 (1):14569. doi: 10.1038/s41598-019-51270-1. PubMed PMID:31602000 PubMed Central PMC6787003.
  10. Das, S, Sahgal, A. Editorial: Contemporary Management of Intracranial Metastatic Disease. Front Oncol. 2019;9 :818. doi: 10.3389/fonc.2019.00818. PubMed PMID:31555585 PubMed Central PMC6724609.
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Affiliations & Other Activities

  • Assistant Professor, Division of Neurosurgery, Department of Surgery, St. Michael’s Hospital
  • Adjunct Scientist, Brain Tumour Research Centre, Hospital for Sick Children
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