Sunit Das

MD, PhD, MA, BA

Scientist, Keenan Research Centre for Biomedical Science

Biography

Dr. Sunit Das is a Scientist in the Keenan Research Centre for Biomedical Science and neurosurgeon at St.Michael’s Hospital. He is an Assistant Professor in the Department of Surgery at the University of Toronto. Dr. Das studied English Literature at the University of Michigan and Philosophy at Harvard University before moving to Chicago for medical school at Northwestern University. He completed a Doctor of Philosophy at the National Institutes of Health, where he studied the molecular processes that underly adult neurogenesis in the lab of Dr. ZuHang Sheng. He returned to Chicago for his neurosurgical residency, during which time he also began work on cancer stem cells in primary brain tumours in the lab of Dr. John Kessler. He was recruited to the University of Toronto in 2010. Dr. Das’s clinical practice and clinical research focus of the treatment of patients with tumours of the brain and spine. His laboratory at the Hospital for SickKids focuses on non-coding RNA and control of cell identity in glioblastoma and neural stem cells. He is a member of the Arthur and Sonia Labatt Brain Tumour Research Centre at the Hospital for Sick Children, and faculty with the Institute of Medical Science and Department of Laboratory Medicine and Pathobiology.

Recent Publications

  1. Nandakumar, P, Mansouri, A, Das, S. The Role of ATRX in Glioma Biology. Front Oncol. 2017;7 :236. doi: 10.3389/fonc.2017.00236. PubMed PMID:29034211 PubMed Central PMC5626857.
  2. Woolman, M, Ferry, I, Kuzan-Fischer, CM, Wu, M, Zou, J, Kiyota, T et al.. Rapid determination of medulloblastoma subgroup affiliation with mass spectrometry using a handheld picosecond infrared laser desorption probe. Chem Sci. 2017;8 (9):6508-6519. doi: 10.1039/c7sc01974b. PubMed PMID:28989676 PubMed Central PMC5628578.
  3. Nissiri, F, Das, S. Letter: A Role for Wild-Type Isocitrate Dehydrogenase 1 in Gliomagenesis. Neurosurgery. 2017; :. doi: 10.1093/neuros/nyx395. PubMed PMID:28973388 .
  4. Das, S, Kim, AH, Chang, S, Berger, MS. Management of Elderly Patients with Glioblastoma after CE.6. Front Oncol. 2017;7 :196. doi: 10.3389/fonc.2017.00196. PubMed PMID:28913179 PubMed Central PMC5582080.
  5. Lan, X, Jörg, DJ, Cavalli, FMG, Richards, LM, Nguyen, LV, Vanner, RJ et al.. Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy. Nature. 2017;549 (7671):227-232. doi: 10.1038/nature23666. PubMed PMID:28854171 PubMed Central PMC5608080.
  6. Park, NI, Guilhamon, P, Desai, K, McAdam, RF, Langille, E, O'Connor, M et al.. ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells. Cell Stem Cell. 2017;21 (2):209-224.e7. doi: 10.1016/j.stem.2017.06.004. PubMed PMID:28712938 .
  7. Yoon, JY, Gao, A, Das, S, Munoz, DG. Epidemiology and clinical characteristics of hemangioblastomas in the elderly: An update. J Clin Neurosci. 2017;43 :264-266. doi: 10.1016/j.jocn.2017.05.029. PubMed PMID:28651893 .
  8. Hussain, A, Sidiropoulos, M, Das, S, Munoz, DG, Nijhawan, N. Orbital cellular blue nevus complicated by malignant melanoma. Can. J. Ophthalmol. 2017;52 (3):e111-e113. doi: 10.1016/j.jcjo.2016.11.025. PubMed PMID:28576220 .
  9. Morrissy, AS, Cavalli, FMG, Remke, M, Ramaswamy, V, Shih, DJH, Holgado, BL et al.. Spatial heterogeneity in medulloblastoma. Nat. Genet. 2017;49 (5):780-788. doi: 10.1038/ng.3838. PubMed PMID:28394352 PubMed Central PMC5553617.
  10. Woolman, M, Gribble, A, Bluemke, E, Zou, J, Ventura, M, Bernards, N et al.. Optimized Mass Spectrometry Analysis Workflow with Polarimetric Guidance for ex vivo and in situ Sampling of Biological Tissues. Sci Rep. 2017;7 (1):468. doi: 10.1038/s41598-017-00272-y. PubMed PMID:28352074 PubMed Central PMC5428042.
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Affiliations & Other Activities

  • Assistant Professor, Division of Neurosurgery, Department of Surgery, St. Michael’s Hospital
  • Adjunct Scientist, Brain Tumour Research Centre, Hospital for Sick Children
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