Sunit Das

MD, PhD, MA, BA

Scientist, Keenan Research Centre for Biomedical Science

Biography

Dr. Sunit Das is a Scientist in the Keenan Research Centre for Biomedical Science and neurosurgeon at St.Michael’s Hospital. He is an Assistant Professor in the Department of Surgery at the University of Toronto. Dr. Das studied English Literature at the University of Michigan and Philosophy at Harvard University before moving to Chicago for medical school at Northwestern University. He completed a Doctor of Philosophy at the National Institutes of Health, where he studied the molecular processes that underly adult neurogenesis in the lab of Dr. ZuHang Sheng. He returned to Chicago for his neurosurgical residency, during which time he also began work on cancer stem cells in primary brain tumours in the lab of Dr. John Kessler. He was recruited to the University of Toronto in 2010. Dr. Das’s clinical practice and clinical research focus of the treatment of patients with tumours of the brain and spine. His laboratory at the Hospital for SickKids focuses on non-coding RNA and control of cell identity in glioblastoma and neural stem cells. He is a member of the Arthur and Sonia Labatt Brain Tumour Research Centre at the Hospital for Sick Children, and faculty with the Institute of Medical Science and Department of Laboratory Medicine and Pathobiology.

Recent Publications

  1. Kaka, N, Hafazalla, K, Samawi, H, Simpkin, A, Perry, J, Sahgal, A et al.. Progression-Free but No Overall Survival Benefit for Adult Patients with Bevacizumab Therapy for the Treatment of Newly Diagnosed Glioblastoma: A Systematic Review and Meta-Analysis. Cancers (Basel). 2019;11 (11):. doi: 10.3390/cancers11111723. PubMed PMID:31689995 .
  2. Sachdeva, R, Wu, M, Johnson, K, Kim, H, Celebre, A, Shahzad, U et al.. BMP signaling mediates glioma stem cell quiescence and confers treatment resistance in glioblastoma. Sci Rep. 2019;9 (1):14569. doi: 10.1038/s41598-019-51270-1. PubMed PMID:31602000 PubMed Central PMC6787003.
  3. Das, S, Sahgal, A. Editorial: Contemporary Management of Intracranial Metastatic Disease. Front Oncol. 2019;9 :818. doi: 10.3389/fonc.2019.00818. PubMed PMID:31555585 PubMed Central PMC6724609.
  4. Erickson, AW, Das, S. The Impact of Targeted Therapy on Intracranial Metastatic Disease Incidence and Survival. Front Oncol. 2019;9 :797. doi: 10.3389/fonc.2019.00797. PubMed PMID:31508362 PubMed Central PMC6716495.
  5. Alghamdi, M, Sahgal, A, Soliman, H, Myrehaug, S, Yang, VXD, Das, S et al.. Postoperative Stereotactic Body Radiotherapy for Spinal Metastases and the Impact of Epidural Disease Grade. Neurosurgery. 2019;85 (6):E1111-E1118. doi: 10.1093/neuros/nyz349. PubMed PMID:31506671 .
  6. Sachdeva, R, Wu, M, Smiljanic, S, Kaskun, O, Ghannad-Zadeh, K, Celebre, A et al.. ID1 Is Critical for Tumorigenesis and Regulates Chemoresistance in Glioblastoma. Cancer Res. 2019;79 (16):4057-4071. doi: 10.1158/0008-5472.CAN-18-1357. PubMed PMID:31292163 .
  7. Nguyen, TK, Sahgal, A, Detsky, J, Soliman, H, Myrehaug, S, Tseng, CL et al.. Single-Fraction Stereotactic Radiosurgery Versus Hippocampal-Avoidance Whole Brain Radiation Therapy for Patients With 10 to 30 Brain Metastases: A Dosimetric Analysis. Int. J. Radiat. Oncol. Biol. Phys. 2019;105 (2):394-399. doi: 10.1016/j.ijrobp.2019.06.2543. PubMed PMID:31283978 .
  8. Maslink, C, Cheng, K, Smith, TR, Das, S. Advanced Age Is Not a Universal Predictor of Poorer Outcome in Patients Undergoing Neurosurgery. World Neurosurg. 2019;130 :e375-e382. doi: 10.1016/j.wneu.2019.06.093. PubMed PMID:31229751 .
  9. Maknojia, S, Tam, F, Das, S, Schweizer, T, Graham, SJ. Visualization of Brain Shift Corrected Functional Magnetic Resonance Imaging Data for Intraoperative Brain Mapping. World Neurosurg X. 2019;2 :100021. doi: 10.1016/j.wnsx.2019.100021. PubMed PMID:31218295 PubMed Central PMC6580887.
  10. Soliman, H, Myrehaug, S, Tseng, CL, Ruschin, M, Hashmi, A, Mainprize, T et al.. Image-Guided, Linac-Based, Surgical Cavity-Hypofractionated Stereotactic Radiotherapy in 5 Daily Fractions for Brain Metastases. Neurosurgery. 2019;85 (5):E860-E869. doi: 10.1093/neuros/nyz162. PubMed PMID:31173150 .
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Affiliations & Other Activities

  • Assistant Professor, Division of Neurosurgery, Department of Surgery, St. Michael’s Hospital
  • Adjunct Scientist, Brain Tumour Research Centre, Hospital for Sick Children
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