Sunit Das

MD, PhD, MA, BA

Scientist, Keenan Research Centre for Biomedical Science

Biography

Dr. Das is a neurosurgeon and scientist at St.Michael’s Hospital and the Keenan Research Centre for Biomedical Science, and Assistant Professor in the Department of Surgery at the University of Toronto. Dr. Das studied English Literature at the University of Michigan and Philosophy at Harvard University before moving to Chicago for medical school at Northwestern University. He completed a doctor of philosophy at the National Institutes of Health, where he studied the molecular processes that underly adult neurogenesis in the lab of Dr. ZuHang Sheng. He returned to Chicago for his neurosurgical residency, during which time he also began work on cancer stem cells in primary brain tumours in the lab of Dr. John Kessler. He was recruited to the University of Toronto in 2010. Dr. Das’s clinical practice and clinical research focus of the treatment of patients with tumours of the brain and spine. His laboratory at the Hospital for SickKids focuses on non-coding RNA and control of cell identity in glioblastoma and neural stem cells. He is a member of the Arthur and Sonia Labatt Brain Tumour Research Centre at the Hospital for SickKids, and faculty with the Institute of Medical Science and Department of Laboratory Medicine and Pathobiology.

Recent Publications

  1. Morrissy, AS, Cavalli, FMG, Remke, M, Ramaswamy, V, Shih, DJH, Holgado, BL et al.. Spatial heterogeneity in medulloblastoma. Nat. Genet. 2017;49 (5):780-788. doi: 10.1038/ng.3838. PubMed PMID:28394352 .
  2. Woolman, M, Gribble, A, Bluemke, E, Zou, J, Ventura, M, Bernards, N et al.. Optimized Mass Spectrometry Analysis Workflow with Polarimetric Guidance for ex vivo and in situ Sampling of Biological Tissues. Sci Rep. 2017;7 (1):468. doi: 10.1038/s41598-017-00272-y. PubMed PMID:28352074 .
  3. Chan, V, Sahgal, A, Egeto, P, Schweizer, T, Das, S. Incidence of seizure in adult patients with intracranial metastatic disease. J. Neurooncol. 2017;131 (3):619-624. doi: 10.1007/s11060-016-2335-2. PubMed PMID:27878505 .
  4. Morrison, MA, Tam, F, Garavaglia, MM, Hare, GM, Cusimano, MD, Schweizer, TA et al.. Sources of Variation Influencing Concordance between Functional MRI and Direct Cortical Stimulation in Brain Tumor Surgery. Front Neurosci. 2016;10 :461. doi: 10.3389/fnins.2016.00461. PubMed PMID:27803645 PubMed Central PMC5067437.
  5. Morrison, MA, Churchill, NW, Cusimano, MD, Schweizer, TA, Das, S, Graham, SJ et al.. Reliability of Task-Based fMRI for Preoperative Planning: A Test-Retest Study in Brain Tumor Patients and Healthy Controls. PLoS ONE. 2016;11 (2):e0149547. doi: 10.1371/journal.pone.0149547. PubMed PMID:26894279 PubMed Central PMC4760755.
  6. Soliman, H, Das, S, Larson, DA, Sahgal, A. Stereotactic radiosurgery (SRS) in the modern management of patients with brain metastases. Oncotarget. 2016;7 (11):12318-30. doi: 10.18632/oncotarget.7131. PubMed PMID:26848525 PubMed Central PMC4914287.
  7. Golestanirad, L, Elahi, B, Graham, SJ, Das, S, Wald, LL. Efficacy and Safety of Pedunculopontine Nuclei (PPN) Deep Brain Stimulation in the Treatment of Gait Disorders: A Meta-Analysis of Clinical Studies. Can J Neurol Sci. 2016;43 (1):120-6. doi: 10.1017/cjn.2015.318. PubMed PMID:26786642 .
  8. Smith, TR, Hulou, MM, Yan, SC, Cote, DJ, Nahed, BV, Babu, MA et al.. Defensive medicine in neurosurgery: the Canadian experience. J. Neurosurg. 2016;124 (5):1524-30. doi: 10.3171/2015.6.JNS15764. PubMed PMID:26566208 .
  9. Morrison, MA, Tam, F, Garavaglia, MM, Golestanirad, L, Hare, GM, Cusimano, MD et al.. A novel tablet computer platform for advanced language mapping during awake craniotomy procedures. J. Neurosurg. 2016;124 (4):938-44. doi: 10.3171/2015.4.JNS15312. PubMed PMID:26473779 .
  10. Smith, TR, Hulou, MM, Abecassis, J, Das, S, Chandler, JP. Use of preoperative FLAIR MRI and ependymal proximity of tumor enhancement as surrogate markers of brain tumor origin. J Clin Neurosci. 2015;22 (9):1397-402. doi: 10.1016/j.jocn.2015.02.029. PubMed PMID:26055954 .
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Affiliations & Other Activities

  • Assistant Professor, Surgery/Neurosurgery, St. Michael’s Hospital
  • Adjunct Scientist, Brain Tumour Research Centre, Hospital for Sick Children