Thomas Parker

MD, FRCPC

Scientist, Keenan Research Centre for Biomedical Science

Email: ParkerTG@smh.ca
Tel: 416-864-5271
Twitter: @SMHPIC

Biography

Our research focuses on the molecular regulation of cardiac-specific gene expression in cardiac hypertrophy and failure. This has involved studies of transcriptional control of gene expression in cultured cardiac muscle, analysis of the molecular response to myocardial infarction, elucidation of signal transduction pathways involved in muscle growth and gene expression, and the identification of novel molecules that regulate cardiac hypertrophy and myocyte apoptosis. We apply transgenic and gene knockout strategies in mice to study the molecular physiology of these novel molecules, with a focus on the S100 family of calcium-binding proteins. Ours was the first group to define a role for these proteins in cardiac pathophysiology and more recently, in pulmonary hypertension.

At present, I am not accepting students in my research laboratory.

Recent Publications

  1. Mofid, A, Newman, NS, Lee, PJ, Abbasi, C, Matkar, PN, Rudenko, D et al.. Cardiac Overexpression of S100A6 Attenuates Cardiomyocyte Apoptosis and Reduces Infarct Size After Myocardial Ischemia-Reperfusion. J Am Heart Assoc. 2017;6 (2):. doi: 10.1161/JAHA.116.004738. PubMed PMID:28174168 PubMed Central PMC5523770.
  2. Rizos, E, Siafakas, N, Katsantoni, E, Skourti, E, Salpeas, V, Rizos, I et al.. Let-7, mir-98 and mir-183 as biomarkers for cancer and schizophrenia [corrected]. PLoS ONE. 2015;10 (4):e0123522. doi: 10.1371/journal.pone.0123522. PubMed PMID:25856466 PubMed Central PMC4391828.
  3. Teichert-Kuliszewska, K, Tsoporis, JN, Desjardins, JF, Yin, J, Wang, L, Kuebler, WM et al.. Absence of the calcium-binding protein, S100A1, confers pulmonary hypertension in mice associated with endothelial dysfunction and apoptosis. Cardiovasc. Res. 2015;105 (1):8-19. doi: 10.1093/cvr/cvu241. PubMed PMID:25395393 .
  4. Rohde, D, Schön, C, Boerries, M, Didrihsone, I, Ritterhoff, J, Kubatzky, KF et al.. S100A1 is released from ischemic cardiomyocytes and signals myocardial damage via Toll-like receptor 4. EMBO Mol Med. 2014;6 (6):778-94. doi: 10.15252/emmm.201303498. PubMed PMID:24833748 PubMed Central PMC4203355.
  5. Yannarelli, G, Tsoporis, JN, Desjardins, JF, Wang, XH, Pourdjabbar, A, Viswanathan, S et al.. Donor mesenchymal stromal cells (MSCs) undergo variable cardiac reprogramming in vivo and predominantly co-express cardiac and stromal determinants after experimental acute myocardial infarction. Stem Cell Rev. 2014;10 (2):304-15. doi: 10.1007/s12015-013-9483-y. PubMed PMID:24287730 .
  6. Tsoporis, JT, Izhar, S, Desjardins, JF, Leong-Poi, H, Parker, TG. Conditional cardiac overexpression of S100A6 attenuates myocyte hypertrophy and apoptosis following myocardial infarction. Curr. Pharm. Des. 2014;20 (12):1941-9. . PubMed PMID:23844739 .
  7. Ormiston, ML, Deng, Y, Rundle, N, Bendjelloul, F, Tsoporis, JN, Parker, TG et al.. A lymphocyte-dependent mode of action for imatinib mesylate in experimental pulmonary hypertension. Am. J. Pathol. 2013;182 (5):1541-51. doi: 10.1016/j.ajpath.2013.01.031. PubMed PMID:23518411 .
  8. Mohammadzadeh, F, Desjardins, JF, Tsoporis, JN, Proteau, G, Leong-Poi, H, Parker, TG et al.. S100B: role in cardiac remodeling and function following myocardial infarction in diabetes. Life Sci. 2013;92 (11):639-47. doi: 10.1016/j.lfs.2012.09.011. PubMed PMID:23000886 .
  9. Smeding, L, Leong-Poi, H, Hu, P, Shan, Y, Haitsma, JJ, Horvath, E et al.. Salutary effect of resveratrol on sepsis-induced myocardial depression. Crit. Care Med. 2012;40 (6):1896-907. doi: 10.1097/CCM.0b013e31824e1370. PubMed PMID:22610192 .
  10. Shukla, PC, Singh, KK, Quan, A, Al-Omran, M, Teoh, H, Lovren, F et al.. BRCA1 is an essential regulator of heart function and survival following myocardial infarction. Nat Commun. 2011;2 :593. doi: 10.1038/ncomms1601. PubMed PMID:22186889 PubMed Central PMC3247816.
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Affiliations & Other Activities

  • Scientist, Li Ka Shing Knowledge Institute, St. Michael’s Hospital
  • Physician-in-Chief, St. Michael’s Hospital
  • Squires-Chalmers Chair of Medicine, University of Toronto
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