Wolfgang Kuebler


Associate Scientist, Keenan Research Centre for Biomedical Science

Research Programs


Wolfgang Kuebler Lab ❯


Dr. Wolfgang Kuebler is an Associate Scientist at the Keenan Research Centre for Biomedical Science of St. Michael’s Hospital. He is a Professor at the University of Toronto in both the Department of Surgery and the Department of Physiology and a Professor of Physiology at the Charité-Universitaetsmedizin Berlin with an endowed professorship by the German Heart Institute Berlin. He is also an Adjunct Professor in the Department of Electrical and Computer Engineering at Ryerson University, and an Adjunct Professor in the College of Graduate Studies and Research at the University of Saskatchewan.

His research interest focuses on translational research in pulmonary and microvascular physiology and pathophysiology, he has published > 120 peer-reviewed articles largely on topics that integrate basic research on intracellular signalling and intercellular communication pathways to the level of the intact organ and organism in complex disease models such as acute lung injury, lung edema, or pulmonary hypertension. A special methodological focus of his work is the use of intravital microscopy and real-time fluorescence imaging techniques in intact organs or life animal models, which he combines with both cell and molecular biology techniques as well as physiological measurements.

He currently serves as Chair of the Section Advisory Committee and as Past-Chair of the Respiration Section for the American Physiological Society. In addition, he is the Chair of the Scientific Advisory Panel for the Ludwig-Boltzmann-Institute for Lung Vascular Research in Graz, Austria, and as Associate Editor for the American Journal of Physiology – Lung Cellular and Molecular Physiology and for Experimental Lung Research. He has served on numerous review panels for Canadian Institutes of Health Research and the Heart & Stroke Foundation, and as ad-hoc reviewer for funding agencies in Canada, UK, Ireland, France, Germany, Austria, Israel, Italy, Poland, and Hungary.

Recent Publications

  1. Kuebler, WM. Lessons from Cancer: Subcellular Drug Targeting of Mitochondrial Hsp90 in Pulmonary Arterial Hypertension. Am. J. Respir. Crit. Care Med. 2018; :. doi: 10.1164/rccm.201801-0200ED. PubMed PMID:29438624 .
  2. Semple, JW, McVey, MJ, Kim, M, Rebetz, J, Kuebler, WM, Kapur, R et al.. Targeting Transfusion-Related Acute Lung Injury: The Journey From Basic Science to Novel Therapies. Crit. Care Med. 2018; :. doi: 10.1097/CCM.0000000000002989. PubMed PMID:29384784 .
  3. Kuebler, WM, Friedberg, MK. Letter by Kuebler and Friedberg Regarding Article, "Pulmonary Artery Denervation by Determining Targeted Ablation Sites for Treatment of Pulmonary Arterial Hypertension". Circ Cardiovasc Interv. 2018;11 (2):e006148. doi: 10.1161/CIRCINTERVENTIONS.117.006148. PubMed PMID:29371213 .
  4. Gutbier, B, Schönrock, SM, Ehrler, C, Haberberger, R, Dietert, K, Gruber, AD et al.. Sphingosine Kinase 1 Regulates Inflammation and Contributes to Acute Lung Injury in Pneumococcal Pneumonia via the Sphingosine-1-Phosphate Receptor 2. Crit. Care Med. 2018; :. doi: 10.1097/CCM.0000000000002916. PubMed PMID:29298188 .
  5. Katira, BH, Kuebler, WM, Kavanagh, BP. Inspiratory preload obliteration may injure lungs via cyclical "on-off" vascular flow. Intensive Care Med. 2017; :. doi: 10.1007/s00134-017-5024-5. PubMed PMID:29270678 .
  6. Yu, FP, Islam, D, Sikora, J, Dworski, S, Gurka', J, Lopez-Vasquez, L et al.. Chronic lung injury and impaired pulmonary function in a mouse model of acid ceramidase deficiency. Am. J. Physiol. Lung Cell Mol. Physiol. 2017; :ajplung002232017. doi: 10.1152/ajplung.00223.2017. PubMed PMID:29167126 .
  7. Aulakh, GK, Mann, A, Belev, G, Wiebe, S, Kuebler, WM, Singh, B et al.. Multiple image x-radiography for functional lung imaging. Phys Med Biol. 2017;63 (1):015009. doi: 10.1088/1361-6560/aa9904. PubMed PMID:29116051 .
  8. Zabini, D, Granton, E, Hu, Y, Miranda, MZ, Weichelt, U, Breuils Bonnet, S et al.. Loss of SMAD3 Promotes Vascular Remodeling in Pulmonary Arterial Hypertension via MRTF Disinhibition. Am. J. Respir. Crit. Care Med. 2018;197 (2):244-260. doi: 10.1164/rccm.201702-0386OC. PubMed PMID:29095649 .
  9. Kuebler, WM. Tides of Blood: Cyclic Changes in Lung Blood Volume during a Single Breath. Am. J. Respir. Cell Mol. Biol. 2017;57 (4):386-387. doi: 10.1165/rcmb.2017-0219ED. PubMed PMID:28960103 .
  10. Blázquez-Prieto, J, López-Alonso, I, Amado-Rodríguez, L, Huidobro, C, González-López, A, Kuebler, WM et al.. Impaired lung repair during neutropenia can be reverted by matrix metalloproteinase-9. Thorax. 2017; :. doi: 10.1136/thoraxjnl-2017-210105. PubMed PMID:28947666 .
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Affiliations & Other Activities


  • Member, Institute for Biomedical Engineering and Science Technology (iBEST) at Ryerson University and St. Michael’s Hospital
  • Professor, Department of Surgery, University of Toronto
  • Professor, Department of Physiology, University of Toronto
  • Full Member, Institute of Medical Sciences Graduate School, University of Toronto
  • Member, Heart & Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research, University of Toronto
  • Professor, Institut of Physiology at the Charité-Universitaetsmedizin Berlin, endowed by the German Heart Institute Berlin
  • Adjunct Professor, Department of Electrical and Computer Engineering, Ryerson University
  • Adjunct Professor, College of Graduate Studies and Research, University of Saskatchewan