Wolfgang Kuebler

MD

Affiliate Scientist

Research Programs

Labs

Wolfgang Kuebler Lab ❯

Biography

Please note Dr. Kuebler will not be accepting summer students.

Dr. Wolfgang Kuebler is an Associate Scientist at the Keenan Research Centre for Biomedical Science of St. Michael’s Hospital. He is a Professor at the University of Toronto in both the Department of Surgery and the Department of Physiology and a Professor of Physiology at the Charité-Universitaetsmedizin Berlin with an endowed professorship by the German Heart Institute Berlin. He is also an Adjunct Professor in the Department of Electrical and Computer Engineering at Ryerson University, and an Adjunct Professor in the College of Graduate Studies and Research at the University of Saskatchewan.

His research interest focuses on translational research in pulmonary and microvascular physiology and pathophysiology, he has published > 120 peer-reviewed articles largely on topics that integrate basic research on intracellular signalling and intercellular communication pathways to the level of the intact organ and organism in complex disease models such as acute lung injury, lung edema, or pulmonary hypertension. A special methodological focus of his work is the use of intravital microscopy and real-time fluorescence imaging techniques in intact organs or life animal models, which he combines with both cell and molecular biology techniques as well as physiological measurements.

He currently serves as Chair of the Section Advisory Committee and as Past-Chair of the Respiration Section for the American Physiological Society. In addition, he is the Chair of the Scientific Advisory Panel for the Ludwig-Boltzmann-Institute for Lung Vascular Research in Graz, Austria, and as Associate Editor for the American Journal of Physiology – Lung Cellular and Molecular Physiology and for Experimental Lung Research. He has served on numerous review panels for Canadian Institutes of Health Research and the Heart & Stroke Foundation, and as ad-hoc reviewer for funding agencies in Canada, UK, Ireland, France, Germany, Austria, Israel, Italy, Poland, and Hungary.

Recent Publications

  1. Weidenfeld, S, Chupin, C, Langner, DI, Zetoun, T, Rozowsky, S, Kuebler, WM et al.. Sodium coupled neutral amino acid transporter SNAT2 counteracts cardiogenic pulmonary edema by driving alveolar fluid clearance. Am J Physiol Lung Cell Mol Physiol. 2021; :. doi: 10.1152/ajplung.00461.2020. PubMed PMID:33439101 .
  2. Hameid, RA, Cormet-Boyaka, E, Kuebler, WM, Uddin, M, Berdiev, BK. SARS-CoV-2 may hijack GPCR signaling pathways to dysregulate lung ion and fluid transport. Am J Physiol Lung Cell Mol Physiol. 2021; :. doi: 10.1152/ajplung.00499.2020. PubMed PMID:33434105 .
  3. Behrens, F, Holle, J, Kuebler, WM, Simmons, S. Extracellular vesicles as regulators of kidney function and disease. Intensive Care Med Exp. 2020;8 (Suppl 1):22. doi: 10.1186/s40635-020-00306-2. PubMed PMID:33336297 PubMed Central PMC7746786.
  4. Amatullah, H, Maron-Gutierrez, T, Shan, Y, Gupta, S, Tsoporis, JN, Varkouhi, AK et al.. Protective function of DJ-1/PARK7 in lipopolysaccharide and ventilator-induced acute lung injury. Redox Biol. 2021;38 :101796. doi: 10.1016/j.redox.2020.101796. PubMed PMID:33246293 PubMed Central PMC7695876.
  5. Heinzel, FR, Hegemann, N, Hohendanner, F, Primessnig, U, Grune, J, Blaschke, F et al.. Left ventricular dysfunction in heart failure with preserved ejection fraction-molecular mechanisms and impact on right ventricular function. Cardiovasc Diagn Ther. 2020;10 (5):1541-1560. doi: 10.21037/cdt-20-477. PubMed PMID:33224773 PubMed Central PMC7666919.
  6. Michalick, L, Weidenfeld, S, Grimmer, B, Fatykhova, D, Solymosi, PD, Behrens, F et al.. Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure. Eur Respir J. 2020; :. doi: 10.1183/13993003.02384-2020. PubMed PMID:33154030 PubMed Central PMC7651836.
  7. Hu, Y, Chi, L, Kuebler, WM, Goldenberg, NM. Perivascular Inflammation in Pulmonary Arterial Hypertension. Cells. 2020;9 (11):. doi: 10.3390/cells9112338. PubMed PMID:33105588 PubMed Central PMC7690279.
  8. Mittermaier, M, Pickerodt, P, Kurth, F, de Jarcy, LB, Uhrig, A, Garcia, C et al.. Evaluation of PEEP and prone positioning in early COVID-19 ARDS. EClinicalMedicine. 2020;28 :100579. doi: 10.1016/j.eclinm.2020.100579. PubMed PMID:33073217 PubMed Central PMC7547915.
  9. Witzenrath, M, Kuebler, WM. Pneumonia in the face of COVID-19. Am J Physiol Lung Cell Mol Physiol. 2020;319 (5):L863-L866. doi: 10.1152/ajplung.00447.2020. PubMed PMID:32996786 .
  10. Ishii, R, Okumura, K, Akazawa, Y, Malhi, M, Ebata, R, Sun, M et al.. Heart Rate Reduction Improves Right Ventricular Function and Fibrosis in Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2020;63 (6):843-855. doi: 10.1165/rcmb.2019-0317OC. PubMed PMID:32915674 .
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Affiliations & Other Activities

 

  • Member, Institute for Biomedical Engineering and Science Technology (iBEST) at Ryerson University and St. Michael’s Hospital
  • Professor, Department of Surgery, University of Toronto
  • Professor, Department of Physiology, University of Toronto
  • Full Member, Institute of Medical Sciences Graduate School, University of Toronto
  • Member, Heart & Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research, University of Toronto
  • Professor, Institut of Physiology at the Charité-Universitaetsmedizin Berlin, endowed by the German Heart Institute Berlin
  • Adjunct Professor, Department of Electrical and Computer Engineering, Ryerson University
  • Adjunct Professor, College of Graduate Studies and Research, University of Saskatchewan
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