Wolfgang Kuebler


Associate Scientist, Keenan Research Centre for Biomedical Science

Research Programs


Wolfgang Kuebler Lab ❯


Please note Dr. Kuebler will not be accepting summer students.

Dr. Wolfgang Kuebler is an Associate Scientist at the Keenan Research Centre for Biomedical Science of St. Michael’s Hospital. He is a Professor at the University of Toronto in both the Department of Surgery and the Department of Physiology and a Professor of Physiology at the Charité-Universitaetsmedizin Berlin with an endowed professorship by the German Heart Institute Berlin. He is also an Adjunct Professor in the Department of Electrical and Computer Engineering at Ryerson University, and an Adjunct Professor in the College of Graduate Studies and Research at the University of Saskatchewan.

His research interest focuses on translational research in pulmonary and microvascular physiology and pathophysiology, he has published > 120 peer-reviewed articles largely on topics that integrate basic research on intracellular signalling and intercellular communication pathways to the level of the intact organ and organism in complex disease models such as acute lung injury, lung edema, or pulmonary hypertension. A special methodological focus of his work is the use of intravital microscopy and real-time fluorescence imaging techniques in intact organs or life animal models, which he combines with both cell and molecular biology techniques as well as physiological measurements.

He currently serves as Chair of the Section Advisory Committee and as Past-Chair of the Respiration Section for the American Physiological Society. In addition, he is the Chair of the Scientific Advisory Panel for the Ludwig-Boltzmann-Institute for Lung Vascular Research in Graz, Austria, and as Associate Editor for the American Journal of Physiology – Lung Cellular and Molecular Physiology and for Experimental Lung Research. He has served on numerous review panels for Canadian Institutes of Health Research and the Heart & Stroke Foundation, and as ad-hoc reviewer for funding agencies in Canada, UK, Ireland, France, Germany, Austria, Israel, Italy, Poland, and Hungary.

Recent Publications

  1. Michalick, L, Kuebler, WM. TRPV4-A Missing Link Between Mechanosensation and Immunity. Front Immunol. 2020;11 :413. doi: 10.3389/fimmu.2020.00413. PubMed PMID:32210976 PubMed Central PMC7076180.
  2. Pappritz, K, Grune, J, Klein, O, Hegemann, N, Dong, F, El-Shafeey, M et al.. Speckle-tracking echocardiography combined with imaging mass spectrometry assesses region-dependent alterations. Sci Rep. 2020;10 (1):3629. doi: 10.1038/s41598-020-60594-2. PubMed PMID:32108156 PubMed Central PMC7046677.
  3. Cool, CD, Kuebler, WM, Bogaard, HJ, Spiekerkoetter, E, Nicolls, MR, Voelkel, NF et al.. The Hallmarks of Severe Pulmonary Arterial Hypertension: The Cancer Hypothesis - Ten years later. Am. J. Physiol. Lung Cell Mol. Physiol. 2020; :. doi: 10.1152/ajplung.00476.2019. PubMed PMID:32023082 .
  4. Grimmer, B, Kuebler, WM. Cholesterol - A Novel Regulator of Vasoreactivity in Pulmonary Arteries. Am. J. Respir. Cell Mol. Biol. 2020; :. doi: 10.1165/rcmb.2020-0020ED. PubMed PMID:32011912 .
  5. Grune, J, Beyhoff, N, Hegemann, N, Lauryn, JH, Kuebler, WM. From bedside to bench: lung ultrasound for the assessment of pulmonary edema in animal models. Cell Tissue Res. 2020; :. doi: 10.1007/s00441-020-03172-2. PubMed PMID:32009189 .
  6. Spiekerkoetter, E, Goncharova, EA, Guignabert, C, Stenmark, K, Kwapiszewska, G, Rabinovitch, M et al.. Hot topics in the mechanisms of pulmonary arterial hypertension disease: cancer-like pathobiology, the role of the adventitia, systemic involvement, and right ventricular failure. Pulm Circ. ;9 (4):2045894019889775. doi: 10.1177/2045894019889775. PubMed PMID:31798835 PubMed Central PMC6868582.
  7. Maibier, M, Bintig, W, Goede, A, Höpfner, M, Kuebler, WM, Secomb, TW et al.. Gap junctions regulate vessel diameter in chick chorioallantoic membrane vasculature by both tone-dependent and structural mechanisms. Microcirculation. 2020;27 (1):e12590. doi: 10.1111/micc.12590. PubMed PMID:31520425 .
  8. McVey, MJ, Kapur, R, Cserti-Gazdewich, C, Semple, JW, Karkouti, K, Kuebler, WM et al.. Transfusion-related Acute Lung Injury in the Perioperative Patient. Anesthesiology. 2019;131 (3):693-715. doi: 10.1097/ALN.0000000000002687. PubMed PMID:31408449 .
  9. Grune, J, Tabuchi, A, Kuebler, WM. Alveolar dynamics during mechanical ventilation in the healthy and injured lung. Intensive Care Med Exp. 2019;7 (Suppl 1):34. doi: 10.1186/s40635-019-0226-5. PubMed PMID:31346797 PubMed Central PMC6658629.
  10. Beyhoff, N, Lohr, D, Foryst-Ludwig, A, Klopfleisch, R, Brix, S, Grune, J et al.. Characterization of Myocardial Microstructure and Function in an Experimental Model of Isolated Subendocardial Damage. Hypertension. 2019;74 (2):295-304. doi: 10.1161/HYPERTENSIONAHA.119.12956. PubMed PMID:31291149 PubMed Central PMC6635061.
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Affiliations & Other Activities


  • Member, Institute for Biomedical Engineering and Science Technology (iBEST) at Ryerson University and St. Michael’s Hospital
  • Professor, Department of Surgery, University of Toronto
  • Professor, Department of Physiology, University of Toronto
  • Full Member, Institute of Medical Sciences Graduate School, University of Toronto
  • Member, Heart & Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research, University of Toronto
  • Professor, Institut of Physiology at the Charité-Universitaetsmedizin Berlin, endowed by the German Heart Institute Berlin
  • Adjunct Professor, Department of Electrical and Computer Engineering, Ryerson University
  • Adjunct Professor, College of Graduate Studies and Research, University of Saskatchewan