Wolfgang Kuebler


Associate Scientist, Keenan Research Centre for Biomedical Science

Research Programs


Wolfgang Kuebler Lab ❯


Dr. Wolfgang Kuebler is an Associate Scientist at the Keenan Research Centre for Biomedical Science of St. Michael’s Hospital. He is a Professor at the University of Toronto in both the Department of Surgery and the Department of Physiology and a Professor of Physiology at the Charité-Universitaetsmedizin Berlin with an endowed professorship by the German Heart Institute Berlin. He is also an Adjunct Professor in the Department of Electrical and Computer Engineering at Ryerson University, and an Adjunct Professor in the College of Graduate Studies and Research at the University of Saskatchewan.

His research interest focuses on translational research in pulmonary and microvascular physiology and pathophysiology, he has published > 120 peer-reviewed articles largely on topics that integrate basic research on intracellular signalling and intercellular communication pathways to the level of the intact organ and organism in complex disease models such as acute lung injury, lung edema, or pulmonary hypertension. A special methodological focus of his work is the use of intravital microscopy and real-time fluorescence imaging techniques in intact organs or life animal models, which he combines with both cell and molecular biology techniques as well as physiological measurements.

He currently serves as Chair of the Section Advisory Committee and as Past-Chair of the Respiration Section for the American Physiological Society. In addition, he is the Chair of the Scientific Advisory Panel for the Ludwig-Boltzmann-Institute for Lung Vascular Research in Graz, Austria, and as Associate Editor for the American Journal of Physiology – Lung Cellular and Molecular Physiology and for Experimental Lung Research. He has served on numerous review panels for Canadian Institutes of Health Research and the Heart & Stroke Foundation, and as ad-hoc reviewer for funding agencies in Canada, UK, Ireland, France, Germany, Austria, Israel, Italy, Poland, and Hungary.

Recent Publications

  1. Grimmer, B, Kuebler, WM. The endothelium in hypoxic pulmonary vasoconstriction. J. Appl. Physiol. 2017; :jap.00120.2017. doi: 10.1152/japplphysiol.00120.2017. PubMed PMID:28860164 .
  2. Hess, R, Wujak, L, Hesse, C, Sewald, K, Jonigk, D, Warnecke, G et al.. Coagulation factor XII regulates inflammatory responses in human lungs. Thromb. Haemost. 2017;117 (10):. doi: 10.1160/TH16-12-0904. PubMed PMID:28816340 .
  3. Katira, BH, Giesinger, RE, Engelberts, D, Zabini, D, Kornecki, A, Otulakowski, G et al.. Adverse Heart-lung Interactions in Ventilator-induced Lung Injury. Am. J. Respir. Crit. Care Med. 2017; :. doi: 10.1164/rccm.201611-2268OC. PubMed PMID:28795839 .
  4. Wang, R, Pan, Q, Kuebler, WM, Li, JK, Pries, AR, Ning, G et al.. Modeling of pulsatile flow-dependent nitric oxide regulation in a realistic microvascular network. Microvasc. Res. 2017;113 :40-49. doi: 10.1016/j.mvr.2017.05.001. PubMed PMID:28478072 .
  5. Weidenfeld, S, Kuebler, WM. Cytokine-Regulation of Na(+)-K(+)-Cl(-) Cotransporter 1 and Cystic Fibrosis Transmembrane Conductance Regulator-Potential Role in Pulmonary Inflammation and Edema Formation. Front Immunol. 2017;8 :393. doi: 10.3389/fimmu.2017.00393. PubMed PMID:28439270 PubMed Central PMC5383711.
  6. Krauszman, A, Mak, TW, Szaszi, K, Kuebler, WM. Role of phosphatase and tensin homolog in hypoxic pulmonary vasoconstriction. Cardiovasc. Res. 2017;113 (8):869-878. doi: 10.1093/cvr/cvx076. PubMed PMID:28430879 .
  7. Yau, JW, Singh, KK, Hou, Y, Lei, X, Ramadan, A, Quan, A et al.. Endothelial-specific deletion of autophagy-related 7 (ATG7) attenuates arterial thrombosis in mice. J. Thorac. Cardiovasc. Surg. 2017;154 (3):978-988.e1. doi: 10.1016/j.jtcvs.2017.02.058. PubMed PMID:28400112 .
  8. Geralde, MC, Leite, IS, Inada, NM, Salina, AC, Medeiros, AI, Kuebler, WM et al.. Pneumonia treatment by photodynamic therapy with extracorporeal illumination - an experimental model. Physiol Rep. 2017;5 (5):. doi: 10.14814/phy2.13190. PubMed PMID:28292878 PubMed Central PMC5350187.
  9. McVey, MJ, Kim, M, Tabuchi, A, Srbely, V, Japtok, L, Arenz, C et al.. Acid sphingomyelinase mediates murine acute lung injury following transfusion of aged platelets. Am. J. Physiol. Lung Cell Mol. Physiol. 2017;312 (5):L625-L637. doi: 10.1152/ajplung.00317.2016. PubMed PMID:28283474 .
  10. Kuebler, WM. The Flow-Dependent Transcription Factor KLF2 Protects Lung Vascular Barrier Function in Acute Respiratory Distress Syndrome. Am. J. Respir. Crit. Care Med. 2017;195 (5):553-555. doi: 10.1164/rccm.201609-1946ED. PubMed PMID:28248139 .
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Affiliations & Other Activities


  • Member, Institute for Biomedical Engineering and Science Technology (iBEST) at Ryerson University and St. Michael’s Hospital
  • Professor, Department of Surgery, University of Toronto
  • Professor, Department of Physiology, University of Toronto
  • Full Member, Institute of Medical Sciences Graduate School, University of Toronto
  • Member, Heart & Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research, University of Toronto
  • Professor, Institut of Physiology at the Charité-Universitaetsmedizin Berlin, endowed by the German Heart Institute Berlin
  • Adjunct Professor, Department of Electrical and Computer Engineering, Ryerson University
  • Adjunct Professor, College of Graduate Studies and Research, University of Saskatchewan