Wolfgang Kuebler

MD

Associate Scientist, Keenan Research Centre for Biomedical Science

Research Programs

Labs

Wolfgang Kuebler Lab ❯

Biography

Please note Dr. Kuebler will not be accepting summer students in 2019.

Dr. Wolfgang Kuebler is an Associate Scientist at the Keenan Research Centre for Biomedical Science of St. Michael’s Hospital. He is a Professor at the University of Toronto in both the Department of Surgery and the Department of Physiology and a Professor of Physiology at the Charité-Universitaetsmedizin Berlin with an endowed professorship by the German Heart Institute Berlin. He is also an Adjunct Professor in the Department of Electrical and Computer Engineering at Ryerson University, and an Adjunct Professor in the College of Graduate Studies and Research at the University of Saskatchewan.

His research interest focuses on translational research in pulmonary and microvascular physiology and pathophysiology, he has published > 120 peer-reviewed articles largely on topics that integrate basic research on intracellular signalling and intercellular communication pathways to the level of the intact organ and organism in complex disease models such as acute lung injury, lung edema, or pulmonary hypertension. A special methodological focus of his work is the use of intravital microscopy and real-time fluorescence imaging techniques in intact organs or life animal models, which he combines with both cell and molecular biology techniques as well as physiological measurements.

He currently serves as Chair of the Section Advisory Committee and as Past-Chair of the Respiration Section for the American Physiological Society. In addition, he is the Chair of the Scientific Advisory Panel for the Ludwig-Boltzmann-Institute for Lung Vascular Research in Graz, Austria, and as Associate Editor for the American Journal of Physiology – Lung Cellular and Molecular Physiology and for Experimental Lung Research. He has served on numerous review panels for Canadian Institutes of Health Research and the Heart & Stroke Foundation, and as ad-hoc reviewer for funding agencies in Canada, UK, Ireland, France, Germany, Austria, Israel, Italy, Poland, and Hungary.

Recent Publications

  1. Wang, R, Li, P, Pan, Q, Li, JK, Kuebler, WM, Pries, AR et al.. Investigation into the diversity in the fractal dimensions of arterioles and venules in a microvascular network - A quantitative analysis. Microvasc. Res. 2019;125 :103882. doi: 10.1016/j.mvr.2019.103882. PubMed PMID:31075242 .
  2. Grune, J, Ritter, D, Kräker, K, Pappritz, K, Beyhoff, N, Schütte, T et al.. Accurate assessment of LV function using the first automated 2D-border detection algorithm for small animals - evaluation and application to models of LV dysfunction. Cardiovasc Ultrasound. 2019;17 (1):7. doi: 10.1186/s12947-019-0156-0. PubMed PMID:31010431 PubMed Central PMC6477743.
  3. Goldenberg, NM, Hu, Y, Hu, X, Volchuk, A, Zhao, YD, Kucherenko, MM et al.. Therapeutic Targeting of High Mobility Group Box-1 in Pulmonary Arterial Hypertension. Am. J. Respir. Crit. Care Med. 2019; :. doi: 10.1164/rccm.201808-1597LE. PubMed PMID:30939030 .
  4. Brack, MC, Lienau, J, Kuebler, WM, Witzenrath, M. Cardiovascular sequelae of pneumonia. Curr Opin Pulm Med. 2019;25 (3):257-262. doi: 10.1097/MCP.0000000000000584. PubMed PMID:30893107 .
  5. McVey, MJ, Maishan, M, Blokland, KEC, Bartlett, N, Kuebler, WM. Extracellular vesicles in lung health, disease, and therapy. Am. J. Physiol. Lung Cell Mol. Physiol. 2019;316 (6):L977-L989. doi: 10.1152/ajplung.00546.2018. PubMed PMID:30892076 .
  6. Pickerodt, PA, Kuebler, WM. Go West: translational physiology for noninvasive measurement of pulmonary gas exchange in patients with hypoxemic lung disease. Am. J. Physiol. Lung Cell Mol. Physiol. 2019;316 (5):L701-L702. doi: 10.1152/ajplung.00515.2018. PubMed PMID:30838868 .
  7. McVey, MJ, Kuebler, WM. Extracellular vesicles: biomarkers and regulators of vascular function during extracorporeal circulation. Oncotarget. 2018;9 (98):37229-37251. doi: 10.18632/oncotarget.26433. PubMed PMID:30647856 PubMed Central PMC6324688.
  8. Kuebler, WM. Acute Respiratory Distress Syndrome: Biomarkers, Mechanisms, and Water Channels. Anesthesiology. 2019;130 (3):364-366. doi: 10.1097/ALN.0000000000002607. PubMed PMID:30624248 .
  9. Sundd, P, Kuebler, WM. Smooth Muscle Cells: A Novel Site of P-selectin Expression with Pathophysiological and Therapeutic Relevance in Pulmonary Hypertension. Am. J. Respir. Crit. Care Med. 2018; :. doi: 10.1164/rccm.201812-2242ED. PubMed PMID:30592637 .
  10. Katira, BH, Kuebler, WM, Connelly, KA, Kavanagh, BP. Reply to Santini et al.: High Positive End-Expiratory Pressure: Only a Dam against Edema Formation? Probably Not (Again). Am. J. Respir. Crit. Care Med. 2019;199 (4):544. doi: 10.1164/rccm.201810-2000LE. PubMed PMID:30398892 .
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Affiliations & Other Activities

 

  • Member, Institute for Biomedical Engineering and Science Technology (iBEST) at Ryerson University and St. Michael’s Hospital
  • Professor, Department of Surgery, University of Toronto
  • Professor, Department of Physiology, University of Toronto
  • Full Member, Institute of Medical Sciences Graduate School, University of Toronto
  • Member, Heart & Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research, University of Toronto
  • Professor, Institut of Physiology at the Charité-Universitaetsmedizin Berlin, endowed by the German Heart Institute Berlin
  • Adjunct Professor, Department of Electrical and Computer Engineering, Ryerson University
  • Adjunct Professor, College of Graduate Studies and Research, University of Saskatchewan
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