Xiao-Yan Wen

MD, PhD

Director, Zebrafish Centre for Advanced Drug Discovery

Biography

Dr. Xiao-Yan Wen’s research focuses on incorporation of zebrafish model system and advanced high throughput screening technologies for drug discovery. He recently established the Zebrafish Centre for Advanced Drug Discovery (ZCADD) at St. Michael’s Hospital. With a large infrastructure funding from Canada Foundation for Innovation (CFI), ZCADD houses Canada’s first fully automated zebrafish high- throughput screening platform for zebrafish. In partnership with many academic labs and industrial partners, the Centre has launched over 10 zebrafish-based drug development projects targeting many neurological, cardiovascular, inflammatory diseases, diabetes and cancer.

Dr. Wen received his MD at Jiangxi Medical University in China and PhD at the University of Toronto. He is currently a Staff Scientist in the Keenan Research Centre for Biomedical Science and an Assistant Professor in the Department of Medicine & Physiology at the University of Toronto. He is the founding director of the Zebrafish Centre for Advanced Drug Discovery and the Director for the St. Micahel’s Hospital Zebrafish Core Facility. He is also an Associate Member of the Institute of Medical Science at the University of Toronto and is directing the graduate course module “Animal Models of Human Diseases”.

Dr. Wen organizes the bi-annual (2013, 2015, 2017) Zebrafish for Personalized/Precision Medicine Conference, in addition to other past events such as the 2011 Zebrafish Functional Genomics Workshop, and 2012 Zebrafish Chemical Biology & Pharmacogenomics Workshop.

Click Here to learn more about the Wen Lab.

Recent Publications

  1. Zabinyakov, N, Bullivant, G, Cao, F, Fernandez Ojeda, M, Jia, ZP, Wen, XY et al.. Characterization of the first knock-out aldh7a1 zebrafish model for pyridoxine-dependent epilepsy using CRISPR-Cas9 technology. PLoS ONE. 2017;12 (10):e0186645. doi: 10.1371/journal.pone.0186645. PubMed PMID:29053735 PubMed Central PMC5650160.
  2. Yougbaré, I, Tai, WS, Zdravic, D, Oswald, BE, Lang, S, Zhu, G et al.. Activated NK cells cause placental dysfunction and miscarriages in fetal alloimmune thrombocytopenia. Nat Commun. 2017;8 (1):224. doi: 10.1038/s41467-017-00269-1. PubMed PMID:28794456 PubMed Central PMC5550461.
  3. Philip, AM, Wang, Y, Mauro, A, El-Rass, S, Marshall, JC, Lee, WL et al.. Development of a zebrafish sepsis model for high-throughput drug discovery. Mol. Med. 2017;23 :. doi: 10.2119/molmed.2016.00188. PubMed PMID:28598490 PubMed Central PMC5522968.
  4. Shi, X, Verma, S, Yun, J, Brand-Arzamendi, K, Singh, KK, Liu, X et al.. Effect of empagliflozin on cardiac biomarkers in a zebrafish model of heart failure: clues to the EMPA-REG OUTCOME trial?. Mol. Cell. Biochem. 2017; :. doi: 10.1007/s11010-017-3018-9. PubMed PMID:28391552 .
  5. El-Rass, S, Eisa-Beygi, S, Khong, E, Brand-Arzamendi, K, Mauro, A, Zhang, H et al.. Disruption of pdgfra alters endocardial and myocardial fusion during zebrafish cardiac assembly. Biol Open. 2017;6 (3):348-357. doi: 10.1242/bio.021212. PubMed PMID:28167492 PubMed Central PMC5374395.
  6. McCutcheon, V, Park, E, Liu, E, Sobhebidari, P, Tavakkoli, J, Wen, XY et al.. A Novel Model of Traumatic Brain Injury in Adult Zebrafish Demonstrates Response to Injury and Treatment Comparable with Mammalian Models. J. Neurotrauma. 2017;34 (7):1382-1393. doi: 10.1089/neu.2016.4497. PubMed PMID:27650063 .
  7. Feng, Y, Yuen, MF, Xu, Q, Wen, XY, Wang, DQ. New Exploration of Chinese Herbal Medicines in Hepatology. Evid Based Complement Alternat Med. 2016;2016 :3056438. doi: 10.1155/2016/3056438. PubMed PMID:27525018 PubMed Central PMC4971296.
  8. Patten, SA, Parker, JA, Wen, XY, Drapeau, P. Simple animal models for amyotrophic lateral sclerosis drug discovery. Expert Opin Drug Discov. 2016;11 (8):797-804. doi: 10.1080/17460441.2016.1196183. PubMed PMID:27249162 .
  9. Hanwell, D, Hutchinson, SA, Collymore, C, Bruce, AE, Louis, R, Ghalami, A et al.. Restrictions on the Importation of Zebrafish into Canada Associated with Spring Viremia of Carp Virus. Zebrafish. 2016;13 Suppl 1 :S153-63. doi: 10.1089/zeb.2016.1286. PubMed PMID:27248438 .
  10. van Karnebeek, CD, Bonafé, L, Wen, XY, Tarailo-Graovac, M, Balzano, S, Royer-Bertrand, B et al.. NANS-mediated synthesis of sialic acid is required for brain and skeletal development. Nat. Genet. 2016;48 (7):777-84. doi: 10.1038/ng.3578. PubMed PMID:27213289 .
Search PubMed

Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Assistant Professor, Department of Medicine, University of Toronto
  • Scientist, Medicine/Hematology, Princess Margaret Hospital
X