John Marshall




Dr. John Marshall is a Professor of Surgery at the University of Toronto, and an Intensivist at St. Michael’s Hospital in Toronto, Canada.  His academic interests are sepsis, trauma, and the innate immune response.  His laboratory studies the cellular mechanisms that prolong neutrophil survival in critical illness by preventing neutrophil programmed cell death, or apoptosis.  Professor Marshall has an active clinical research interest in sepsis and Intensive Care Unit-acquired infection, and in the design of clinical trials and outcome measures.  He has published 440 manuscripts, and 85 book chapters, and is the editor of 2 books.  He is the founding chair of the International Forum of Acute Care Trialists (InFACT) – a global network of investigator-led critical care clinical research groups, and past Secretary-General of the World Federation of Societies of Intensive and Critical Care Medicine.  He co-chairs the WHO R&D Working Group on the Clinical Characterization and Management of COVID-19.  He is past-chair of the International Sepsis Forum, past-President of the Surgical Infection Society, and past-chair of the Canadian Critical Care Trials Group.  He has given invited lectures at more than 540 meetings around the world, and is an Associate Editor of the journals Critical Care Medicine and Critical care.”

Recent Publications

  1. Takaoka, A, Zytaruk, N, Davis, M, Matte, A, Johnstone, J, Lauzier, F et al.. Monitoring and auditing protocol adherence, data integrity and ethical conduct of a randomized clinical trial: A case study. J Crit Care. 2022;71 :154094. doi: 10.1016/j.jcrc.2022.154094. PubMed PMID:35724443 .
  2. Maslove, DM, Tang, B, Shankar-Hari, M, Lawler, PR, Angus, DC, Baillie, JK et al.. Redefining critical illness. Nat Med. 2022;28 (6):1141-1148. doi: 10.1038/s41591-022-01843-x. PubMed PMID:35715504 .
  3. Casey, JD, Beskow, LM, Brown, J, Brown, SM, Gayat, É, Ng Gong, M et al.. Use of pragmatic and explanatory trial designs in acute care research: lessons from COVID-19. Lancet Respir Med. 2022; :. doi: 10.1016/S2213-2600(22)00044-3. PubMed PMID:35709825 .
  4. McIntyre, LA, Marshall, JC. Intravenous Fluids in Septic Shock - More or Less?. N Engl J Med. 2022; :. doi: 10.1056/NEJMe2206160. PubMed PMID:35709013 .
  5. Ailenberg, M, Kapus, A, Leung, CH, Szaszi, K, Williams, P, diCiano-Oliveira, C et al.. Activation of The Mitochondrial Antiviral Signaling Protein (MAVS) Following Liver Ischemia/Reperfusion and Its Effect on Inflammation and Injury. Shock. 2022; :. doi: 10.1097/SHK.0000000000001949. PubMed PMID:35670454 .
  6. Fu, N, Bollegala, N, Jacobson, K, Kroeker, KI, Frost, K, Afif, W et al.. Canadian Consensus Statements on the Transition of Adolescents and Young Adults with Inflammatory Bowel Disease from Pediatric to Adult Care: A Collaborative Initiative Between the Canadian IBD Transition Network and Crohn's and Colitis Canada. J Can Assoc Gastroenterol. 2022;5 (3):105-115. doi: 10.1093/jcag/gwab050. PubMed PMID:35669843 PubMed Central PMC9157291.
  7. Turpin, W, Dong, M, Sasson, G, Raygoza Garay, JA, Espin-Garcia, O, Lee, SH et al.. Mediterranean-Like Dietary Pattern Associations With Gut Microbiome Composition and Subclinical Gastrointestinal Inflammation. Gastroenterology. 2022; :. doi: 10.1053/j.gastro.2022.05.037. PubMed PMID:35643175 .
  8. Gupta, S, Amatullah, H, Tsoporis, JN, Wei, K, Monteiro, APT, Ektesabi, AM et al.. DJ-1 binds to Rubicon to Impair LC-3 Associated Phagocytosis. Cell Death Differ. 2022; :. doi: 10.1038/s41418-022-00993-2. PubMed PMID:35641782 .
  9. Bleck, TP, Buchman, TG, Chang, CWJ, Dellinger, RP, Deutschman, CS, Kadri, SS et al.. The authors reply. Crit Care Med. 2022;50 (6):e604-e606. doi: 10.1097/CCM.0000000000005529. PubMed PMID:35612454 .
  10. Sharif, S, Greer, A, Skorupski, C, Hao, Q, Johnstone, J, Dionne, JC et al.. Probiotics in Critical Illness: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Crit Care Med. 2022; :. doi: 10.1097/CCM.0000000000005580. PubMed PMID:35608319 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science
  • Trauma Surgeon and Intensivist, St. Michael’s Hospital
  • Professor, Department of Surgery, University of Toronto