Mario Ostrowski

MD, FRCP

Scientist

Biography

My current research interests focus on the immunopathogenesis of Human Immunodeficiency Virus (HIV) /Acquired Immune Deficiency Syndrome (AIDS) and Hepatitis C Virus (HCV) and other virus infections including SARS-CoV-2. We are interested in understanding why chronic virus infections persist in the host. Current work is divided along the following lines:

  1. Examination of T cell immune response to HIV and HCV infection.
  2. Therapeutic and preventive vaccine strategies
  3. immunomodulation during virus infections

Recent Publications

  1. Lin, J, Law, R, Korosec, CS, Zhou, C, Koh, WH, Ghaemi, MS et al.. Longitudinal Assessment of SARS-CoV-2-Specific T Cell Cytokine-Producing Responses for 1 Year Reveals Persistence of Multicytokine Proliferative Responses, with Greater Immunity Associated with Disease Severity. J Virol. 2022; :e0050922. doi: 10.1128/jvi.00509-22. PubMed PMID:35699447 .
  2. Sheikh-Mohamed, S, Isho, B, Chao, GYC, Zuo, M, Cohen, C, Lustig, Y et al.. Systemic and mucosal IgA responses are variably induced in response to SARS-CoV-2 mRNA vaccination and are associated with protection against subsequent infection. Mucosal Immunol. 2022; :. doi: 10.1038/s41385-022-00511-0. PubMed PMID:35468942 PubMed Central PMC9037584.
  3. Wong, MK, Liu, JT, Budylowksi, P, Yue, FY, Li, Z, Rini, JM et al.. Convergent CDR3 homology amongst Spike-specific antibody responses in convalescent COVID-19 subjects receiving the BNT162b2 vaccine. Clin Immunol. 2022;237 :108963. doi: 10.1016/j.clim.2022.108963. PubMed PMID:35259543 PubMed Central PMC8897198.
  4. Kuczynski, AM, Krajden, S, Spears, J, Kus, JV, Munoz, DG, Ostrowski, M et al.. Mycobacterium genavense Central Nervous System Infection in a Patient with AIDS. Can J Neurol Sci. 2022; :1-3. doi: 10.1017/cjn.2022.6. PubMed PMID:35220993 .
  5. Liu, J, Budylowski, P, Samson, R, Griffin, BD, Babuadze, G, Rathod, B et al.. Preclinical evaluation of a SARS-CoV-2 mRNA vaccine PTX-COVID19-B. Sci Adv. 2022;8 (3):eabj9815. doi: 10.1126/sciadv.abj9815. PubMed PMID:35044832 PubMed Central PMC8769538.
  6. Zhan, W, Hatchette, T, Yue, F, Liu, J, Song, H, Zhao, H et al.. Impaired Memory B-Cell Response to Influenza Immunization in Patients With Common Variable Immunodeficiency (CVID). Pathog Immun. 2021;6 (2):105-118. doi: 10.20411/pai.v6i2.405. PubMed PMID:34988341 PubMed Central PMC8714177.
  7. Costiniuk, CT, Singer, J, Langlois, MA, Kulic, I, Needham, J, Burchell, A et al.. CTN 328: immunogenicity outcomes in people living with HIV in Canada following vaccination for COVID-19 (HIV-COV): protocol for an observational cohort study. BMJ Open. 2021;11 (12):e054208. doi: 10.1136/bmjopen-2021-054208. PubMed PMID:34916326 PubMed Central PMC8678543.
  8. Law, JC, Girard, M, Chao, GYC, Ward, LA, Isho, B, Rathod, B et al.. Persistence of T Cell and Antibody Responses to SARS-CoV-2 Up to 9 Months after Symptom Onset. J Immunol. 2022;208 (2):429-443. doi: 10.4049/jimmunol.2100727. PubMed PMID:34903642 .
  9. Liu, Y, Budylowski, P, Dong, S, Li, Z, Goroshko, S, Leung, LYT et al.. SARS-CoV-2-Reactive Mucosal B Cells in the Upper Respiratory Tract of Uninfected Individuals. J Immunol. 2021;207 (10):2581-2588. doi: 10.4049/jimmunol.2100606. PubMed PMID:34607939 .
  10. Rahman, AN, Liu, J, Mujib, S, Kidane, S, Ali, A, Szep, S et al.. Elevated glycolysis imparts functional ability to CD8+ T cells in HIV infection. Life Sci Alliance. 2021;4 (11):. doi: 10.26508/lsa.202101081. PubMed PMID:34548381 PubMed Central PMC8473722.
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Affiliations & Other Activities

  • Infectious Disease Consultant, St. Michael’s Hospital
  • Professor, Department of Medicine, Immunology, Lab Medicine, Pathobiology, University of Toronto