Matthew Muller




Dr. Matthew Muller is an infectious diseases physician and the Medical Director of Infection Prevention and Control at Unity Health Toronto. He is an Associate Professor at the University of Toronto in the Department of Medicine. His research interests are focused on the epidemiology and previous of hospital-acquired infections including C. difficile, infections due to common antibiotic-resistant organisms and emerging infectious threats such as MERS-CoV and SARS-CoV2. Dr. Muller has a particular interest in hand hygiene measurement and improvement including the use of novel technological approaches to hand hygiene improvement. Dr. Muller chairs the Provincial Infectious Diseases Advisory Committee on Infection Prevention and Control, and is also interested in guideline and policy development with respect to infection prevention for Ontario hospitals.

Recent Publications

  1. Loong, D, Pham, B, Amiri, M, Saunders, H, Mishra, S, Radhakrishnan, A et al.. Systematic Review on the Cost-Effectiveness of Seasonal Influenza Vaccines in Older Adults. Value Health. 2022; :. doi: 10.1016/j.jval.2022.03.011. PubMed PMID:35659487 .
  2. Bettinger, JA, Sadarangani, M, De Serres, G, Valiquette, L, Vanderkooi, OG, Kellner, JD et al.. The Canadian National Vaccine Safety Network: surveillance of adverse events following immunisation among individuals immunised with the COVID-19 vaccine, a cohort study in Canada. BMJ Open. 2022;12 (1):e051254. doi: 10.1136/bmjopen-2021-051254. PubMed PMID:35058258 PubMed Central PMC8783966.
  3. Williams, V, Kovacs-Litman, A, Muller, MP, Hota, S, Powis, JE, Ricciuto, DR et al.. Impact of COVID-19 on hospital hand hygiene performance: a multicentre observational study using group electronic monitoring. CMAJ Open. ;9 (4):E1175-E1180. doi: 10.9778/cmajo.20210072. PubMed PMID:34906993 PubMed Central PMC8687486.
  4. Barker, KR, Santino, M, LiPuma, JJ, Tullis, E, Muller, MP, Matukas, LM et al.. Fourier Transform Infrared Spectroscopy for Typing Burkholderia cenocepacia ET12 Isolates. Microbiol Spectr. 2021;9 (3):e0183121. doi: 10.1128/Spectrum.01831-21. PubMed PMID:34878338 PubMed Central PMC8653821.
  5. Leis, JA, Obaidallah, M, Williams, V, Muller, MP, Powis, JE, Johnstone, J et al.. Validation and implementation of group electronic hand hygiene monitoring across twenty-four critical care units. Infect Control Hosp Epidemiol. 2021; :1-6. doi: 10.1017/ice.2021.250. PubMed PMID:34784996 .
  6. Sniekers, DC, Jung, JKH, Blake, PG, Cooper, R, Leis, JA, Muller, MP et al.. Province-Wide Prevalence Testing for SARS-CoV-2 of In-Center Hemodialysis Patients and Staff in Ontario, Canada: A Cross-Sectional Study. Can J Kidney Health Dis. 2021;8 :20543581211036213. doi: 10.1177/20543581211036213. PubMed PMID:34394945 PubMed Central PMC8358577.
  7. Schwartz, KL, Muller, MP, Williams, V, Harry, R, Booker, S, Katz, K et al.. Coronavirus disease 2019 (COVID-19) risk among healthcare workers performing nasopharyngeal testing. Infect Control Hosp Epidemiol. 2022;43 (3):395-397. doi: 10.1017/ice.2021.354. PubMed PMID:34338181 PubMed Central PMC8387686.
  8. Paphitis, K, Achonu, C, Callery, S, Gubbay, J, Katz, K, Muller, M et al.. Beyond flu: Trends in respiratory infection outbreaks in Ontario healthcare settings from 2007 to 2017, and implications for non-influenza outbreak management. Can Commun Dis Rep. 2021;47 (56):269-275. doi: 10.14745/ccdr.v47i56a04. PubMed PMID:34220351 PubMed Central PMC8219065.
  9. Tan, DHS, Chan, AK, Jüni, P, Tomlinson, G, Daneman, N, Walmsley, S et al.. Post-exposure prophylaxis against SARS-CoV-2 in close contacts of confirmed COVID-19 cases (CORIPREV): study protocol for a cluster-randomized trial. Trials. 2021;22 (1):224. doi: 10.1186/s13063-021-05134-7. PubMed PMID:33752741 PubMed Central PMC7982877.
  10. Leis, JA, Muller, MP. Reply to Cawthorne and Cooke. Clin Infect Dis. 2021;73 (1):e278-e279. doi: 10.1093/cid/ciaa1924. PubMed PMID:33386404 .
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Affiliations & Other Activities

  • Medical Director, Infection Prevention and Control, St. Michael’s Hospital
  • Assistant Professor, Department of Medicine, University of Toronto