june, 2017

1jun9:00 am- 10:00 amGenetic Epidemiology Research Based in Electronic Health Records: Part 1 Population Structure, Mating Patterns and Self-Identified Race/Ethnicity


Event Details


These two talks will focus primarily on the Kaiser Permanente Northern California Research Program on Genes, Environment and Health (RPGEH), and the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort derived therefrom. This multi-ethnic cohort, established in 2005, is representative of Northern California and contains over 100,000 individuals with comprehensive electronic health record data that dates back over 20 years for most individuals.

In 2009, genome-wide genotype and telomere length data were added through an NIH Grand Opportunity Award, facilitating genetic epidemiologic research on a large scale.

In the first of the two lectures, we will focus on the demographic structure of this cohort, which contains a large number of spouse, parent-child and sibling pairs. We show the relationship between how individuals self-identify in terms of race/ethnicity/nationality and their genetic ancestry, and also mating patterns that have and continue to determine the population genetic structure of the sample.

In the second of the two lectures, we will focus on the application of the genome-wide genotype and telomere data to a number of disease and clinical trait outcomes. The resource includes all aspects of care, including laboratory tests, pathology reports, physiologic tests and pharmacy prescription data, in addition to clinical diagnoses. Through examples, we demonstrate the power of this clinically homogeneous resource for gene discovery, as well as gene characterization through longitudinal analyses based in the EHR data. We also provide examples of cross-ethnic analyses, pleiotropy, pharmacogenetics and heritability.

CIHR STAGE is a training program in genetic epidemiology and statistical genetics, housed at the University of Toronto Dalla Lana School of Public Health, and funded by the Canadian Institutes of Health Research through the Strategic Training Initiative in Health Research Program. Seminars are sponsored by The Hospital for Sick Children; the Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; the Ontario Institute for Cancer Research; the McLaughlin Centre of the University of Toronto; the Ontario Cancer Institute of the University Health Network; and the CIHR Institute of Genetics.

Photography Disclosure: Photographs and/or video may be taken of participants at CIHR STAGE events. These photos/videos are for the Program’s use only and may appear on its website, in printed brochures, or in other promotional or reporting materials. By attending CIHR STAGE events, you accept the possibility that you may be videotaped or photographed. If you have any concerns, please inform us by sending an e-mail to patricia.nguyen@utoronto.ca.

Part 2. Linking the genome to longitudinal disease and trait data

Date: Friday June 2, 2017

Time: 12:00pm-1:00pm


The Hospital for Sick Children
Daniels Hollywood Theatre
Room 1246, 1st Floor, Black Wing,
555 University Avenue, Toronto, ON


(Thursday) 9:00 am - 10:00 am


Peter Gilgan Centre for Research adn Learning Main Auditorium

Comments are closed.