Title: "Modeling Human Development and Disease Using Pluripotent Stem Cells" Hans-Willem Snoeck, M.D., PhD, Professor of Medicine (in Microbiology & Immunology)
Title: “Modeling Human Development and Disease Using Pluripotent Stem Cells”
Hans-Willem Snoeck, M.D., PhD, Professor of Medicine (in Microbiology & Immunology)
Date: November 2nd, 2018 | 1-2 pm
Location: Li Ka Shing Knowledge Institute Auditorium, 2nd floor, Li Ka Shing Knowledge Institute, 209 Victoria Street, St. Michael’s Hospital
Presenting on behalf of the Biomedical Delivery Systems (BDS) Research Theme.
The research program of the Snoeck lab primarily focuses on hematopoiesis with the aim to improve bone marrow transplantation and gene therapy targeted at hematopoietic stem cells (HSCs), and gain insight in leukemogenesis. To achieve a deeper understanding of the mechanisms involved in self-renewal of HSCs, we have mapped genes underlying quantitative genetic variation in the behavior of HSCs among inbred mouse strains. After identifying allelic variation in the Prdm16 gene as one of the underlying mechanisms, the lab now focuses on the mechanism of action of Prdm16 in the renewal of HSCs. Expansion of this program into directed differentiation of human embryonic stem cells (ESCs) and induced pluripotent state cells (iPSCs) (collectively called human pluritpotent cells (hPSCs)) arose from the desire to attempt to alleviate post-bone marrow transplantation immune deficiency, caused, among others, by defective T cell reconstitution. Furthermore, the capacity to generate thymic epithelial cells from human pluripotent stem cells will allow the generation of the next generation of “personal immune” mice. As the thymus develops from the anterior foregut endoderm, the approaches we developed also led to strategies to generate virtually every type of cell of the respiratory system from hPSCs.
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