Arthur S. Slutsky

MD, M.A.Sc., B.A.Sc.

Scientist

Biography

My major research interests relate to the lung injury caused by mechanical ventilation: so called ventilator-induced lung injury (VILI). Specifically, my lab is working on (1) biotrauma: the molecular mechanisms by which injurious forms of mechanical ventilation can lead to release of mediators; (2) the mechanisms by which these mediators can affect distal organs (e.g. kidney, liver, etc.) and lead to multiple organ dysfunction syndrome (MODS); and (3) therapeutic approaches (ventilatory and non-ventilatory) to mitigate VILI and biotrauma. My laboratory works very closely with Dr. Zhang’s laboratory, and makes use of a number of model systems including in vitro, ex vivo cell and various animal models. As well, I have a major interest in clinical trials related to mechanical ventilation, acute lung injury (ALI), acute respiratory distress syndrome (ARDS), and COVID-19.

 

Recent Publications

  1. Brown, PE, Fu, SH, Bansal, A, Newcombe, L, Colwill, K, Mailhot, G et al.. Omicron BA.1/1.1 SARS-CoV-2 Infection among Vaccinated Canadian Adults. N Engl J Med. 2022; :. doi: 10.1056/NEJMc2202879. PubMed PMID:35584302 .
  2. Tonetti, T, Ranieri, VM, Navalesi, P, Nava, S, Slutsky, AS. Reply: High-Flow Oxygen Therapy for Severe Hypoxemia: Moving Towards a More Inclusive Definition of ARDS. Am J Respir Crit Care Med. 2022; :. doi: 10.1164/rccm.202202-0332LE. PubMed PMID:35549642 .
  3. Ismaiel, N, Whynot, S, Geldenhuys, L, Xu, Z, Slutsky, AS, Chappe, V et al.. Lung-Protective Ventilation Attenuates Mechanical Injury While Hypercapnia Attenuates Biological Injury in a Rat Model of Ventilator-Associated Lung Injury. Front Physiol. 2022;13 :814968. doi: 10.3389/fphys.2022.814968. PubMed PMID:35530505 PubMed Central PMC9068936.
  4. Villar, J, Mora-Ordoñez, JM, Soler, JA, Mosteiro, F, Vidal, A, Ambrós, A et al.. The PANDORA Study: Prevalence and Outcome of Acute Hypoxemic Respiratory Failure in the Pre-COVID-19 Era. Crit Care Explor. 2022;4 (5):e0684. doi: 10.1097/CCE.0000000000000684. PubMed PMID:35510152 PubMed Central PMC9061169.
  5. Best, JR, Wang, M, Lee, T, Russell, JA, DeMarco, ML, ARBs CORONA I Investigators et al.. Early increases in anti-SARS-CoV-2 antibody isotypes associated with organ dysfunction and mortality in patients hospitalized with COVID-19. Intensive Care Med. 2022;48 (5):616-618. doi: 10.1007/s00134-022-06662-9. PubMed PMID:35364729 PubMed Central PMC8975731.
  6. Brodie, D, Abrams, D, MacLaren, G, Brown, CE, Evans, L, Barbaro, RP et al.. ECMO During Respiratory Pandemics: Past, Present, and Future. Am J Respir Crit Care Med. 2022; :. doi: 10.1164/rccm.202111-2661CP. PubMed PMID:35213298 .
  7. Dianti, J, Tisminetzky, M, Ferreyro, BL, Englesakis, M, Del Sorbo, L, Sud, S et al.. Association of PEEP and Lung Recruitment Selection Strategies with Mortality in Acute Respiratory Distress Syndrome: A Systematic Review and Network Meta-Analysis. Am J Respir Crit Care Med. 2022; :. doi: 10.1164/rccm.202108-1972OC. PubMed PMID:35180042 .
  8. Tang, X, Sharma, A, Pasic, M, Brown, P, Colwill, K, Gelband, H et al.. Assessment of SARS-CoV-2 Seropositivity During the First and Second Viral Waves in 2020 and 2021 Among Canadian Adults. JAMA Netw Open. 2022;5 (2):e2146798. doi: 10.1001/jamanetworkopen.2021.46798. PubMed PMID:35171263 PubMed Central PMC8851304.
  9. Levy, B, Girerd, N, Amour, J, Besnier, E, Nesseler, N, Helms, J et al.. Effect of Moderate Hypothermia vs Normothermia on 30-Day Mortality in Patients With Cardiogenic Shock Receiving Venoarterial Extracorporeal Membrane Oxygenation: A Randomized Clinical Trial. JAMA. 2022;327 (5):442-453. doi: 10.1001/jama.2021.24776. PubMed PMID:35103766 PubMed Central PMC8808325.
  10. Abrams, D, Agerstrand, C, Beitler, JR, Karagiannidis, C, Madahar, P, Yip, NH et al.. Risks and Benefits of Ultra-Lung-Protective Invasive Mechanical Ventilation Strategies with a Focus on Extracorporeal Support. Am J Respir Crit Care Med. 2022;205 (8):873-882. doi: 10.1164/rccm.202110-2252CP. PubMed PMID:35044901 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Keenan Chair in Medicine, St. Michael’s Hospital
  • Professor, Departments of Medicine, Biomedical Engineering and Surgery, University of Toronto
  • Chair, Clinical Trials Ontario
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