Arthur S. Slutsky

MD, M.A.Sc., B.A.Sc.

Scientist

Biography

My major research interests relate to the lung injury caused by mechanical ventilation: so called ventilator-induced lung injury (VILI). Specifically, my lab is working on (1) biotrauma: the molecular mechanisms by which injurious forms of mechanical ventilation can lead to release of mediators; (2) the mechanisms by which these mediators can affect distal organs (e.g. kidney, liver, etc.) and lead to multiple organ dysfunction syndrome (MODS); and (3) therapeutic approaches (ventilatory and non-ventilatory) to mitigate VILI and biotrauma. My laboratory makes use of a number of model systems including in vitro, ex vivo cell and various animal models. As well, I have an interest in clinical trials related to mechanical ventilation, acute lung injury (ALI) and acute respiratory distress syndrome (ARDS).

 

Recent Publications

  1. Dianti, J, Slutsky, AS, Goligher, EC. Validity of Empirical Estimates of the Ratio of Dead Space to Tidal Volume in ARDS. Respir Care. 2020; :. doi: 10.4187/respcare.08246. PubMed PMID:33082218 .
  2. Mittermaier, M, Pickerodt, P, Kurth, F, de Jarcy, LB, Uhrig, A, Garcia, C et al.. Evaluation of PEEP and prone positioning in early COVID-19 ARDS. EClinicalMedicine. 2020; :100579. doi: 10.1016/j.eclinm.2020.100579. PubMed PMID:33073217 PubMed Central PMC7547915.
  3. Vincent, JL, Slutsky, AS. We've never seen a patient with ARDS!. Intensive Care Med. 2020; :. doi: 10.1007/s00134-020-06255-4. PubMed PMID:33051737 PubMed Central PMC7553366.
  4. Trahtemberg, U, Slutsky, AS, Villar, J. What have we learned ventilating COVID-19 patients?. Intensive Care Med. 2020; :. doi: 10.1007/s00134-020-06275-0. PubMed PMID:33044572 PubMed Central PMC7549087.
  5. Del Sorbo, L, Goffi, A, Tomlinson, G, Pettenuzzo, T, Facchin, F, Vendramin, A et al.. Effect of Driving Pressure Change During Extracorporeal Membrane Oxygenation in Adults With Acute Respiratory Distress Syndrome: A Randomized Crossover Physiologic Study. Crit Care Med. 2020; :. doi: 10.1097/CCM.0000000000004637. PubMed PMID:33044283 .
  6. Barbaro, RP, MacLaren, G, Boonstra, PS, Iwashyna, TJ, Slutsky, AS, Fan, E et al.. Extracorporeal membrane oxygenation support in COVID-19: an international cohort study of the Extracorporeal Life Support Organization registry. Lancet. 2020;396 (10257):1071-1078. doi: 10.1016/S0140-6736(20)32008-0. PubMed PMID:32987008 PubMed Central PMC7518880.
  7. WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group, Sterne, JAC, Murthy, S, Diaz, JV, Slutsky, AS, Villar, J et al.. Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis. JAMA. 2020;324 (13):1330-1341. doi: 10.1001/jama.2020.17023. PubMed PMID:32876694 PubMed Central PMC7489434.
  8. Grasselli, G, Tonetti, T, Protti, A, Langer, T, Girardis, M, Bellani, G et al.. Pathophysiology of COVID-19-associated acute respiratory distress syndrome: a multicentre prospective observational study. Lancet Respir Med. 2020; :. doi: 10.1016/S2213-2600(20)30370-2. PubMed PMID:32861276 .
  9. Sterne, JAC, Diaz, J, Villar, J, Murthy, S, Slutsky, AS, Perner, A et al.. Corticosteroid therapy for critically ill patients with COVID-19: A structured summary of a study protocol for a prospective meta-analysis of randomized trials. Trials. 2020;21 (1):734. doi: 10.1186/s13063-020-04641-3. PubMed PMID:32831155 PubMed Central PMC7443535.
  10. Bréchot, N, Hajage, D, Kimmoun, A, Demiselle, J, Agerstrand, C, Montero, S et al.. Venoarterial extracorporeal membrane oxygenation to rescue sepsis-induced cardiogenic shock: a retrospective, multicentre, international cohort study. Lancet. 2020;396 (10250):545-552. doi: 10.1016/S0140-6736(20)30733-9. PubMed PMID:32828186 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Keenan Chair in Medicine, St. Michael’s Hospital
  • Professor, Departments of Medicine, Biomedical Engineering and Surgery, University of Toronto
  • Chair, Clinical Trials Ontario
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