Arthur S. Slutsky

MD, M.A.Sc., B.A.Sc.

Scientist

Biography

My major research interests relate to the lung injury caused by mechanical ventilation: so called ventilator-induced lung injury (VILI). Specifically, my lab is working on (1) biotrauma: the molecular mechanisms by which injurious forms of mechanical ventilation can lead to release of mediators; (2) the mechanisms by which these mediators can affect distal organs (e.g. kidney, liver, etc.) and lead to multiple organ dysfunction syndrome (MODS); and (3) therapeutic approaches (ventilatory and non-ventilatory) to mitigate VILI and biotrauma. My laboratory works very closely with Dr. Zhang’s laboratory, and makes use of a number of model systems including in vitro, ex vivo cell and various animal models. As well, I have a major interest in clinical trials related to mechanical ventilation, acute lung injury (ALI), acute respiratory distress syndrome (ARDS), and COVID-19.

 

Recent Publications

  1. Telias, I, Brochard, LJ, Gattarello, S, Wunsch, H, Junhasavasdikul, D, Bosma, KJ et al.. The physiological underpinnings of life-saving respiratory support. Intensive Care Med. 2022; :. doi: 10.1007/s00134-022-06749-3. PubMed PMID:35690953 .
  2. Chen, L, Grieco, DL, Beloncle, F, Chen, GQ, Tiribelli, N, Madotto, F et al.. Partition of respiratory mechanics in patients with acute respiratory distress syndrome and association with outcome: a multicentre clinical study. Intensive Care Med. 2022; :. doi: 10.1007/s00134-022-06724-y. PubMed PMID:35670818 .
  3. Rocheleau, GLY, Lee, T, Mohammed, Y, Goodlett, D, Burns, K, Cheng, MP et al.. Renin-Angiotensin System Pathway Therapeutics Associated With Improved Outcomes in Males Hospitalized With COVID-19. Crit Care Med. 2022; :. doi: 10.1097/CCM.0000000000005589. PubMed PMID:35607951 .
  4. Brown, PE, Fu, SH, Bansal, A, Newcombe, L, Colwill, K, Mailhot, G et al.. Omicron BA.1/1.1 SARS-CoV-2 Infection among Vaccinated Canadian Adults. N Engl J Med. 2022;386 (24):2337-2339. doi: 10.1056/NEJMc2202879. PubMed PMID:35584302 .
  5. Tonetti, T, Ranieri, VM, Navalesi, P, Nava, S, Slutsky, AS. Reply: High-Flow Oxygen Therapy for Severe Hypoxemia: Moving Towards a More Inclusive Definition of ARDS. Am J Respir Crit Care Med. 2022; :. doi: 10.1164/rccm.202202-0332LE. PubMed PMID:35549642 .
  6. Ismaiel, N, Whynot, S, Geldenhuys, L, Xu, Z, Slutsky, AS, Chappe, V et al.. Lung-Protective Ventilation Attenuates Mechanical Injury While Hypercapnia Attenuates Biological Injury in a Rat Model of Ventilator-Associated Lung Injury. Front Physiol. 2022;13 :814968. doi: 10.3389/fphys.2022.814968. PubMed PMID:35530505 PubMed Central PMC9068936.
  7. Villar, J, Mora-Ordoñez, JM, Soler, JA, Mosteiro, F, Vidal, A, Ambrós, A et al.. The PANDORA Study: Prevalence and Outcome of Acute Hypoxemic Respiratory Failure in the Pre-COVID-19 Era. Crit Care Explor. 2022;4 (5):e0684. doi: 10.1097/CCE.0000000000000684. PubMed PMID:35510152 PubMed Central PMC9061169.
  8. Best, JR, Wang, M, Lee, T, Russell, JA, DeMarco, ML, ARBs CORONA I Investigators et al.. Early increases in anti-SARS-CoV-2 antibody isotypes associated with organ dysfunction and mortality in patients hospitalized with COVID-19. Intensive Care Med. 2022;48 (5):616-618. doi: 10.1007/s00134-022-06662-9. PubMed PMID:35364729 PubMed Central PMC8975731.
  9. Brodie, D, Abrams, D, MacLaren, G, Brown, CE, Evans, L, Barbaro, RP et al.. Extracorporeal Membrane Oxygenation during Respiratory Pandemics: Past, Present, and Future. Am J Respir Crit Care Med. 2022;205 (12):1382-1390. doi: 10.1164/rccm.202111-2661CP. PubMed PMID:35213298 .
  10. Dianti, J, Tisminetzky, M, Ferreyro, BL, Englesakis, M, Del Sorbo, L, Sud, S et al.. Association of Positive End-Expiratory Pressure and Lung Recruitment Selection Strategies with Mortality in Acute Respiratory Distress Syndrome: A Systematic Review and Network Meta-analysis. Am J Respir Crit Care Med. 2022;205 (11):1300-1310. doi: 10.1164/rccm.202108-1972OC. PubMed PMID:35180042 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Keenan Chair in Medicine, St. Michael’s Hospital
  • Professor, Departments of Medicine, Biomedical Engineering and Surgery, University of Toronto
  • Chair, Clinical Trials Ontario
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