Arthur S. Slutsky

MD, M.A.Sc., B.A.Sc.

Scientist

Biography

My major research interests relate to the lung injury caused by mechanical ventilation: so called ventilator-induced lung injury (VILI). Specifically, my lab is working on (1) biotrauma: the molecular mechanisms by which injurious forms of mechanical ventilation can lead to release of mediators; (2) the mechanisms by which these mediators can affect distal organs (e.g. kidney, liver, etc.) and lead to multiple organ dysfunction syndrome (MODS); and (3) therapeutic approaches (ventilatory and non-ventilatory) to mitigate VILI and biotrauma. My laboratory makes use of a number of model systems including in vitro, ex vivo cell and various animal models. As well, I have an interest in clinical trials related to mechanical ventilation, acute lung injury (ALI) and acute respiratory distress syndrome (ARDS).

 

Recent Publications

  1. Jüni, P, Rothenbühler, M, Bobos, P, Thorpe, KE, da Costa, BR, Fisman, DN et al.. Impact of climate and public health interventions on the COVID-19 pandemic: A prospective cohort study. CMAJ. 2020; :. doi: 10.1503/cmaj.200920. PubMed PMID:32385067 .
  2. Monteil, V, Kwon, H, Prado, P, Hagelkrüys, A, Wimmer, RA, Stahl, M et al.. Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2. Cell. 2020;181 (4):905-913.e7. doi: 10.1016/j.cell.2020.04.004. PubMed PMID:32333836 PubMed Central PMC7181998.
  3. Madotto, F, Rezoagli, E, Pham, T, Schmidt, M, McNicholas, B, Protti, A et al.. Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome: insights from the LUNG SAFE study. Crit Care. 2020;24 (1):125. doi: 10.1186/s13054-020-2826-6. PubMed PMID:32234077 PubMed Central PMC7110678.
  4. Vincent, JL, Slutsky, AS. Coronavirus: just imagine…. Crit Care. 2020;24 (1):90. doi: 10.1186/s13054-020-2824-8. PubMed PMID:32178716 PubMed Central PMC7077011.
  5. Zhang, H, Penninger, JM, Li, Y, Zhong, N, Slutsky, AS. Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target. Intensive Care Med. 2020;46 (4):586-590. doi: 10.1007/s00134-020-05985-9. PubMed PMID:32125455 PubMed Central PMC7079879.
  6. Xie, J, Tong, Z, Guan, X, Du, B, Qiu, H, Slutsky, AS et al.. Critical care crisis and some recommendations during the COVID-19 epidemic in China. Intensive Care Med. 2020;46 (5):837-840. doi: 10.1007/s00134-020-05979-7. PubMed PMID:32123994 PubMed Central PMC7080165.
  7. Sklar, MC, Dres, M, Fan, E, Rubenfeld, GD, Scales, DC, Herridge, MS et al.. Association of Low Baseline Diaphragm Muscle Mass With Prolonged Mechanical Ventilation and Mortality Among Critically Ill Adults. JAMA Netw Open. 2020;3 (2):e1921520. doi: 10.1001/jamanetworkopen.2019.21520. PubMed PMID:32074293 .
  8. Zhang, B, Ratano, D, Brochard, LJ, Georgopoulos, D, Duffin, J, Long, M et al.. A physiology-based mathematical model for the selection of appropriate ventilator controls for lung and diaphragm protection. J Clin Monit Comput. 2020; :. doi: 10.1007/s10877-020-00479-x. PubMed PMID:32008149 PubMed Central PMC7224026.
  9. Dufresne, J, Bowden, P, Thavarajah, T, Florentinus-Mefailoski, A, Chen, ZZ, Tucholska, M et al.. The plasma peptides of breast versus ovarian cancer. Clin Proteomics. 2019;16 :43. doi: 10.1186/s12014-019-9262-0. PubMed PMID:31889940 PubMed Central PMC6927194.
  10. Bertoni, M, Telias, I, Urner, M, Long, M, Del Sorbo, L, Fan, E et al.. A novel non-invasive method to detect excessively high respiratory effort and dynamic transpulmonary driving pressure during mechanical ventilation. Crit Care. 2019;23 (1):346. doi: 10.1186/s13054-019-2617-0. PubMed PMID:31694692 PubMed Central PMC6836358.
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Keenan Chair in Medicine, St. Michael’s Hospital
  • Professor, Departments of Medicine, Biomedical Engineering and Surgery, University of Toronto
  • Chair, Clinical Trials Ontario
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