Arthur S. Slutsky

MD, M.A.Sc., B.A.Sc.

Scientist

Biography

My major research interests relate to the lung injury caused by mechanical ventilation: so called ventilator-induced lung injury (VILI). Specifically, my lab is working on (1) biotrauma: the molecular mechanisms by which injurious forms of mechanical ventilation can lead to release of mediators; (2) the mechanisms by which these mediators can affect distal organs (e.g. kidney, liver, etc.) and lead to multiple organ dysfunction syndrome (MODS); and (3) therapeutic approaches (ventilatory and non-ventilatory) to mitigate VILI and biotrauma. My laboratory makes use of a number of model systems including in vitro, ex vivo cell and various animal models. As well, I have an interest in clinical trials related to mechanical ventilation, acute lung injury (ALI) and acute respiratory distress syndrome (ARDS).

 

Recent Publications

  1. Mamdani, M, Slutsky, AS. Artificial intelligence in intensive care medicine. Intensive Care Med. 2020; :. doi: 10.1007/s00134-020-06203-2. PubMed PMID:32767073 .
  2. Ferrando, C, Suarez-Sipmann, F, Mellado-Artigas, R, Hernández, M, Gea, A, Arruti, E et al.. Clinical features, ventilatory management, and outcome of ARDS caused by COVID-19 are similar to other causes of ARDS. Intensive Care Med. 2020; :. doi: 10.1007/s00134-020-06192-2. PubMed PMID:32728965 PubMed Central PMC7387884.
  3. Combes, A, Price, S, Slutsky, AS, Brodie, D. Temporary circulatory support for cardiogenic shock. Lancet. 2020;396 (10245):199-212. doi: 10.1016/S0140-6736(20)31047-3. PubMed PMID:32682486 .
  4. Han, JS, Mashari, A, Singh, D, Dianti, J, Goligher, E, Long, M et al.. Personalized Ventilation to Multiple Patients Using a Single Ventilator: Description and Proof of Concept. Crit Care Explor. 2020;2 (5):e0118. doi: 10.1097/CCE.0000000000000118. PubMed PMID:32671348 PubMed Central PMC7259561.
  5. Li, Y, Jerkic, M, Slutsky, AS, Zhang, H. Molecular mechanisms of sex bias differences in COVID-19 mortality. Crit Care. 2020;24 (1):405. doi: 10.1186/s13054-020-03118-8. PubMed PMID:32646459 PubMed Central PMC7347256.
  6. Fan, E, Beitler, JR, Brochard, L, Calfee, CS, Ferguson, ND, Slutsky, AS et al.. COVID-19-associated acute respiratory distress syndrome: is a different approach to management warranted?. Lancet Respir Med. 2020;8 (8):816-821. doi: 10.1016/S2213-2600(20)30304-0. PubMed PMID:32645311 PubMed Central PMC7338016.
  7. Thavarajah, T, Dos Santos, CC, Slutsky, AS, Marshall, JC, Bowden, P, Romaschin, A et al.. The plasma peptides of sepsis. Clin Proteomics. 2020;17 :26. doi: 10.1186/s12014-020-09288-5. PubMed PMID:32636717 PubMed Central PMC7331219.
  8. Madotto, F, Rezoagli, E, McNicholas, BA, Pham, T, Slutsky, AS, Bellani, G et al.. Patterns and impact of arterial CO2 management in patients with Acute Respiratory Distress Syndrome: Insights from the LUNG SAFE study. Chest. 2020; :. doi: 10.1016/j.chest.2020.05.605. PubMed PMID:32589951 .
  9. Jüni, P, Rothenbühler, M, Bobos, P, Thorpe, KE, da Costa, BR, Fisman, DN et al.. Impact of climate and public health interventions on the COVID-19 pandemic: a prospective cohort study. CMAJ. 2020;192 (21):E566-E573. doi: 10.1503/cmaj.200920. PubMed PMID:32385067 PubMed Central PMC7259972.
  10. Monteil, V, Kwon, H, Prado, P, Hagelkrüys, A, Wimmer, RA, Stahl, M et al.. Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2. Cell. 2020;181 (4):905-913.e7. doi: 10.1016/j.cell.2020.04.004. PubMed PMID:32333836 PubMed Central PMC7181998.
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Keenan Chair in Medicine, St. Michael’s Hospital
  • Professor, Departments of Medicine, Biomedical Engineering and Surgery, University of Toronto
  • Chair, Clinical Trials Ontario
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