Arthur S. Slutsky

MD, M.A.Sc., B.A.Sc.

Scientist

Biography

My major research interests relate to the lung injury caused by mechanical ventilation: so called ventilator-induced lung injury (VILI). Specifically, my lab is working on (1) biotrauma: the molecular mechanisms by which injurious forms of mechanical ventilation can lead to release of mediators; (2) the mechanisms by which these mediators can affect distal organs (e.g. kidney, liver, etc.) and lead to multiple organ dysfunction syndrome (MODS); and (3) therapeutic approaches (ventilatory and non-ventilatory) to mitigate VILI and biotrauma. My laboratory makes use of a number of model systems including in vitro, ex vivo cell and various animal models. As well, I have an interest in clinical trials related to mechanical ventilation, acute lung injury (ALI) and acute respiratory distress syndrome (ARDS).

 

Recent Publications

  1. Burns, KEA, Rizvi, L, Cook, DJ, Dodek, P, Slutsky, AS, Jones, A et al.. Variation in the practice of discontinuing mechanical ventilation in critically ill adults: study protocol for an international prospective observational study. BMJ Open. 2019;9 (9):e031775. doi: 10.1136/bmjopen-2019-031775. PubMed PMID:31501132 .
  2. Goligher, EC, Combes, A, Brodie, D, Ferguson, ND, Pesenti, AM, Ranieri, VM et al.. Determinants of the effect of extracorporeal carbon dioxide removal in the SUPERNOVA trial: implications for trial design. Intensive Care Med. 2019;45 (9):1219-1230. doi: 10.1007/s00134-019-05708-9. PubMed PMID:31432216 .
  3. Brodie, D, Slutsky, AS, Combes, A. Extracorporeal Life Support for Adults With Respiratory Failure and Related Indications: A Review. JAMA. 2019;322 (6):557-568. doi: 10.1001/jama.2019.9302. PubMed PMID:31408142 .
  4. Abrams, D, Pham, T, Burns, KEA, Combes, A, Curtis, JR, Mueller, T et al.. Practice Patterns and Ethical Considerations in the Management of Venovenous Extracorporeal Membrane Oxygenation Patients: An International Survey. Crit. Care Med. 2019;47 (10):1346-1355. doi: 10.1097/CCM.0000000000003910. PubMed PMID:31356471 .
  5. Montandon, G, Slutsky, AS. Solving the Opioid Crisis: Respiratory Depression by Opioids as Critical End Point. Chest. 2019; :. doi: 10.1016/j.chest.2019.05.015. PubMed PMID:31194974 .
  6. McNicholas, BA, Rezoagli, E, Pham, T, Madotto, F, Guiard, E, Fanelli, V et al.. Impact of Early Acute Kidney Injury on Management and Outcome in Patients With Acute Respiratory Distress Syndrome: A Secondary Analysis of a Multicenter Observational Study. Crit. Care Med. 2019;47 (9):1216-1225. doi: 10.1097/CCM.0000000000003832. PubMed PMID:31162201 .
  7. Slutsky, AS, Villar, J. Early Paralytic Agents for ARDS? Yes, No, and Sometimes. N. Engl. J. Med. 2019;380 (21):2061-2063. doi: 10.1056/NEJMe1905627. PubMed PMID:31112382 .
  8. Hamilton, M, Tomlinson, G, Chu, L, Robles, P, Matte, A, Burns, S et al.. Determinants of Depressive Symptoms at 1 Year Following ICU Discharge in Survivors of ≥ 7 Days of Mechanical Ventilation: Results From the RECOVER Program, a Secondary Analysis of a Prospective Multicenter Cohort Study. Chest. 2019;156 (3):466-476. doi: 10.1016/j.chest.2019.04.104. PubMed PMID:31102611 .
  9. Goligher, EC, Tomlinson, G, Slutsky, AS. Post Hoc Bayesian Analyses-Reply. JAMA. 2019;321 (16):1632-1633. doi: 10.1001/jama.2019.1202. PubMed PMID:31012927 .
  10. Zhang, H, Li, Y, Slutsky, AS. Precision medicine for cell therapy in acute respiratory distress syndrome. Lancet Respir Med. 2019;7 (4):e13. doi: 10.1016/S2213-2600(19)30089-X. PubMed PMID:30926050 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Keenan Chair in Medicine, St. Michael’s Hospital
  • Professor, Departments of Medicine, Biomedical Engineering and Surgery, University of Toronto
  • Chair, Clinical Trials Ontario
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