Arthur S. Slutsky

MD, M.A.Sc., B.A.Sc.

Scientist

Biography

My major research interests relate to the lung injury caused by mechanical ventilation: so called ventilator-induced lung injury (VILI). Specifically, my lab is working on (1) biotrauma: the molecular mechanisms by which injurious forms of mechanical ventilation can lead to release of mediators; (2) the mechanisms by which these mediators can affect distal organs (e.g. kidney, liver, etc.) and lead to multiple organ dysfunction syndrome (MODS); and (3) therapeutic approaches (ventilatory and non-ventilatory) to mitigate VILI and biotrauma. My laboratory works very closely with Dr. Zhang’s laboratory, and makes use of a number of model systems including in vitro, ex vivo cell and various animal models. As well, I have a major interest in clinical trials related to mechanical ventilation, acute lung injury (ALI), acute respiratory distress syndrome (ARDS), and COVID-19.

 

Recent Publications

  1. Verma, AA, Slutsky, AS, Razak, F. The consequences of neglecting to collect multisectoral data to monitor the COVID-19 pandemic. CMAJ. 2021;193 (41):E1600. doi: 10.1503/cmaj.80136. PubMed PMID:34663605 .
  2. López-Fernández, YM, Martínez-de-Azagra, A, González-Gómez, JM, Pérez-Caballero Macarrón, C, García-González, M, Parrilla-Parrilla, J et al.. Acute Hypoxemic Respiratory Failure in Children at the Start of COVID-19 Outbreak: A Nationwide Experience. J Clin Med. 2021;10 (19):. doi: 10.3390/jcm10194301. PubMed PMID:34640318 PubMed Central PMC8509571.
  3. Tran, A, Fernando, SM, Brochard, LJ, Fan, E, Inaba, K, Ferguson, ND et al.. Prognostic factors for development of acute respiratory distress syndrome following traumatic injury - a systematic review and meta-analysis. Eur Respir J. 2021; :. doi: 10.1183/13993003.00857-2021. PubMed PMID:34625477 .
  4. Barbaro, RP, MacLaren, G, Boonstra, PS, Combes, A, Agerstrand, C, Annich, G et al.. Extracorporeal membrane oxygenation for COVID-19: evolving outcomes from the international Extracorporeal Life Support Organization Registry. Lancet. 2021;398 (10307):1230-1238. doi: 10.1016/S0140-6736(21)01960-7. PubMed PMID:34599878 PubMed Central PMC8480964.
  5. Tonetti, T, Grasselli, G, Rucci, P, Alessandri, F, Dell'Olio, A, Boscolo, A et al.. Synergistic Effect of Static Compliance and D-dimers to Predict Outcome of Patients with COVID-19-ARDS: A Prospective Multicenter Study. Biomedicines. 2021;9 (9):. doi: 10.3390/biomedicines9091228. PubMed PMID:34572414 PubMed Central PMC8467668.
  6. Abrams, D, MacLaren, G, Lorusso, R, Price, S, Yannopoulos, D, Vercaemst, L et al.. Extracorporeal cardiopulmonary resuscitation in adults: evidence and implications. Intensive Care Med. 2021; :. doi: 10.1007/s00134-021-06514-y. PubMed PMID:34505911 PubMed Central PMC8429884.
  7. Amado-Rodríguez, L, Del Busto, C, López-Alonso, I, Parra, D, Mayordomo-Colunga, J, Arias-Guillén, M et al.. Biotrauma during ultra-low tidal volume ventilation and venoarterial extracorporeal membrane oxygenation in cardiogenic shock: a randomized crossover clinical trial. Ann Intensive Care. 2021;11 (1):132. doi: 10.1186/s13613-021-00919-0. PubMed PMID:34453620 PubMed Central PMC8397875.
  8. REMAP-CAP Investigators, ACTIV-4a Investigators, ATTACC Investigators, Goligher, EC, Bradbury, CA, McVerry, BJ et al.. Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19. N Engl J Med. 2021;385 (9):777-789. doi: 10.1056/NEJMoa2103417. PubMed PMID:34351722 PubMed Central PMC8362592.
  9. ATTACC Investigators, ACTIV-4a Investigators, REMAP-CAP Investigators, Lawler, PR, Goligher, EC, Berger, JS et al.. Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19. N Engl J Med. 2021;385 (9):790-802. doi: 10.1056/NEJMoa2105911. PubMed PMID:34351721 PubMed Central PMC8362594.
  10. Costa, ELV, Slutsky, AS, Amato, MBP. Reply to Camporota et al.: The 4DPRR Index and Mechanical Power: A Step Ahead or 4 Steps Backward?. Am J Respir Crit Care Med. 2021;204 (4):492-493. doi: 10.1164/rccm.202105-1113LE. PubMed PMID:34081876 PubMed Central PMC8480244.
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Keenan Chair in Medicine, St. Michael’s Hospital
  • Professor, Departments of Medicine, Biomedical Engineering and Surgery, University of Toronto
  • Chair, Clinical Trials Ontario
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