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C. David Mazer

MD with Great Distinction

Scientist

Email: David.Mazer@unityhealth.to
Tel: 416-864-5825

Research Programs

Biography

Please note: Dr. Mazer is not taking any summer students.

My academic interests relate to cardiovascular disease and include cardiac anesthesia and critical care. My research program focuses on perioperative blood conservation, cardiac physiology and metabolism and perioperative organ protection. I am actively engaged in translational research as an investigator in both pre-clinical and clinical studies in these areas.

Recent Publications

  1. Beattie, WS, Lalu, M, Bocock, M, Feng, S, Wijeysundera, DN, Nagele, P et al.. Systematic review and consensus definitions for the Standardized Endpoints in Perioperative Medicine (StEP) initiative: cardiovascular outcomes. Br J Anaesth. 2021;126 (1):56-66. doi: 10.1016/j.bja.2020.09.023. PubMed PMID:33092804 .
  2. STARRT-AKI Investigators, Canadian Critical Care Trials Group, Australian and New Zealand Intensive Care Society Clinical Trials Group, United Kingdom Critical Care Research Group, Canadian Nephrology Trials Network, Irish Critical Care Trials Group et al.. Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury. N Engl J Med. 2020;383 (3):240-251. doi: 10.1056/NEJMoa2000741. PubMed PMID:32668114 .
  3. Shander, A, Brown, J, Licker, M, Mazer, DC, Meier, J, Ozawa, S et al.. Standards and Best Practice for Acute Normovolemic Hemodilution: Evidence-based Consensus Recommendations. J Cardiothorac Vasc Anesth. 2020;34 (7):1755-1760. doi: 10.1053/j.jvca.2020.01.019. PubMed PMID:32127266 .
  4. Spence, J, Young, J, Alhazzani, W, Whitlock, R, D'Aragon, F, Um, K et al.. Safety and efficacy of perioperative benzodiazepine administration: study protocol for a systematic review and meta-analysis. BMJ Open. 2019;9 (12):e031895. doi: 10.1136/bmjopen-2019-031895. PubMed PMID:31831540 PubMed Central PMC6924818.
  5. Fergusson, DA, Avey, MT, Barron, CC, Bocock, M, Biefer, KE, Boet, S et al.. Reporting preclinical anesthesia study (REPEAT): Evaluating the quality of reporting in the preclinical anesthesiology literature. PLoS One. 2019;14 (5):e0215221. doi: 10.1371/journal.pone.0215221. PubMed PMID:31120888 PubMed Central PMC6532843.
  6. Barron, CC, Lalu, MM, Stewart, DJ, Fergusson, D, Yang, H, Moher, D et al.. Assessment of safety and efficacy of mesenchymal stromal cell therapy in preclinical models of acute myocardial infarction: a systematic review protocol. Syst Rev. 2017;6 (1):226. doi: 10.1186/s13643-017-0601-9. PubMed PMID:29116020 PubMed Central PMC5688817.
  7. Mehta, RH, Leimberger, JD, van Diepen, S, Meza, J, Wang, A, Jankowich, R et al.. Levosimendan in Patients with Left Ventricular Dysfunction Undergoing Cardiac Surgery. N Engl J Med. 2017;376 (21):2032-2042. doi: 10.1056/NEJMoa1616218. PubMed PMID:28316276 .
  8. Deschamps, A, Hall, R, Grocott, H, Mazer, CD, Choi, PT, Turgeon, AF et al.. Cerebral Oximetry Monitoring to Maintain Normal Cerebral Oxygen Saturation during High-risk Cardiac Surgery: A Randomized Controlled Feasibility Trial. Anesthesiology. 2016;124 (4):826-36. doi: 10.1097/ALN.0000000000001029. PubMed PMID:26808629 .
  9. Hébert, PC, Fergusson, DA, Hutton, B, Mazer, CD, Fremes, S, Blajchman, M et al.. Regulatory decisions pertaining to aprotinin may be putting patients at risk. CMAJ. 2014;186 (18):1379-86. doi: 10.1503/cmaj.131582. PubMed PMID:25267766 PubMed Central PMC4259771.
  10. Wiesenthal, JD, Fazio, LM, Perks, AE, Blew, BD, Mazer, D, Hare, G et al.. Effect of pneumoperitoneum on renal tissue oxygenation and blood flow in a rat model. Urology. 2011;77 (6):1508.e9-15. doi: 10.1016/j.urology.2011.02.022. PubMed PMID:21507469 .
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Affiliations & Other Activities

  • Associate Scientist, Li Ka Shing Knowledge Institute,  St. Michael’s Hospital
  • Vice-Chair for Research, Department of Anesthesia, University of Toronto
  • Professor, Department of Anesthesia, University of Toronto
  • Professor, Department of Physiology (cross appointment), University of Toronto
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