Charles de Mestral




Dr. Charles de Mestral is a vascular surgeon at St. Michael’s Hospital and a Surgeon-Scientist in the Department of Surgery of the University of Toronto. He conducts research on clinical effectiveness, as well as the provision, quality and costs of surgical care.  His primary research focus is amputation prevention in people with diabetes and peripheral artery disease. His work is based out of the Li Ka Shing Knowledge Institute of St. Michael’s Hospital and ICES.

Please note: Dr. de Mestral is no longer accepting summer students.


Recent Publications

  1. de Mestral, C, Hussain, MA, Austin, PC, Forbes, TL, Sivaswamy, A, Kayssi, A et al.. Regional health care services and rates of lower extremity amputation related to diabetes and peripheral artery disease: an ecological study. CMAJ Open. ;8 (4):E659-E666. doi: 10.9778/cmajo.20200048. PubMed PMID:33109531 PubMed Central PMC7595755.
  2. Rocha, RV, De Mestral, C, Tam, DY, Lee, DS, Al-Omran, M, Austin, PC et al.. Health care costs of endovascular compared with open thoracoabdominal aortic aneurysm repair. J Vasc Surg. 2020; :. doi: 10.1016/j.jvs.2020.09.034. PubMed PMID:33098943 .
  3. Khan, H, Gallant, R, Jain, S, Al-Omran, M, De Mestral, C, Greco, E et al.. Ticagrelor as an Alternative Antiplatelet Therapy in Cardiac Patients Non-Sensitive to Aspirin. Medicina (Kaunas). 2020;56 (10):. doi: 10.3390/medicina56100519. PubMed PMID:33023261 PubMed Central PMC7600331.
  4. Salata, K, Almaghlouth, I, Hussain, MA, de Mestral, C, Greco, E, Aljabri, BA et al.. Outcomes of abdominal aortic aneurysm repair among patients with rheumatoid arthritis. J Vasc Surg. 2020; :. doi: 10.1016/j.jvs.2020.08.134. PubMed PMID:32950628 .
  5. Jacob-Brassard, J, Al-Omran, M, Nathens, AB, Forbes, TL, de Mestral, C. Management and In-hospital Mortality of 2235 Patients With a Traumatic Intimal Tear of the Thoracic Aorta. Ann Surg. 2020; :. doi: 10.1097/SLA.0000000000004415. PubMed PMID:32889880 .
  6. Muaddi, H, Hafid, ME, Choi, WJ, Lillie, E, de Mestral, C, Nathens, A et al.. Clinical Outcomes of Robotic Surgery Compared to Conventional Surgical Approaches (Laparoscopic or Open): A Systematic Overview of Reviews. Ann Surg. 2021;273 (3):467-473. doi: 10.1097/SLA.0000000000003915. PubMed PMID:32398482 .
  7. Syed, MH, Salata, K, Hussain, MA, Zamzam, A, de Mestral, C, Wheatcroft, M et al.. The economic burden of inpatient diabetic foot ulcers in Toronto, Canada. Vascular. 2020;28 (5):520-529. doi: 10.1177/1708538120923420. PubMed PMID:32379584 .
  8. Salata, K, Abdallah, FW, Hussain, MA, de Mestral, C, Greco, E, Aljabri, B et al.. Short-term outcomes of combined neuraxial and general anaesthesia versus general anaesthesia alone for elective open abdominal aortic aneurysm repair: retrospective population-based cohort study. Br J Anaesth. 2020;124 (5):544-552. doi: 10.1016/j.bja.2020.01.018. PubMed PMID:32216957 .
  9. Levy, J, Gupta, V, Amirazodi, E, Allen-Ayodabo, C, Jivraj, N, Jeong, Y et al.. Textbook Outcome and Survival in Patients With Gastric Cancer: An Analysis of the Population Registry of Esophageal and Stomach Tumours in Ontario (PRESTO). Ann Surg. 2020; :. doi: 10.1097/SLA.0000000000003849. PubMed PMID:32149825 .
  10. Rokoszak, V, Syed, MH, Salata, K, Greco, E, de Mestral, C, Hussain, MA et al.. A systematic review and meta-analysis of plain versus drug-eluting balloon angioplasty in the treatment of juxta-anastomotic hemodialysis arteriovenous fistula stenosis. J Vasc Surg. 2020;71 (3):1046-1054.e1. doi: 10.1016/j.jvs.2019.07.075. PubMed PMID:32089200 .
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Affiliations & Other Activities

  • Surgeon, Division of Vascular Surgery, St. Michael’s Hospital
  • Assistant Professor, Department of Surgery, University of Toronto
  • Adjunct Scientist, Institute for Clinical Evaluative Sciences