Charles de Mestral




Dr. Charles de Mestral is a vascular surgeon at St. Michael’s Hospital and a Surgeon-Scientist in the Department of Surgery of the University of Toronto. He conducts research on clinical effectiveness, as well as the provision, quality and costs of surgical care.  His primary research focus is amputation prevention in people with diabetes and peripheral artery disease. His work is based out of the Li Ka Shing Knowledge Institute of St. Michael’s Hospital and ICES.

Please note: Dr. de Mestral is no longer accepting summer students.


Recent Publications

  1. Sue-Chue-Lam, C, Zhang, DD, Baxter, NN, Zywiel, MG, de Mestral, C. Hyaluronate Carboxymethylcellulose Sheets for the Prevention of Adhesive Complications: A Model-Based Cost-Utility Analysis. Colorectal Dis. 2021; :. doi: 10.1111/codi.15724. PubMed PMID:33973319 .
  2. de Mestral, C, Gomez, D, Sue-Chue-Lam, C, Dossa, F, Nantais, J, Simpson, AN et al.. Variable impact of COVID-19 on urgent intervention in Ontario. Br J Surg. 2021; :. doi: 10.1093/bjs/znab121. PubMed PMID:33899084 .
  3. Ramsay, L, Richardson, M, Sander, B, Rahal, M, Wu, D, Setterfield, M et al.. Predicting surgery waiting list volumes and health outcomes among people with an abdominal aortic aneurysm. Br J Surg. 2021; :. doi: 10.1093/bjs/znab074. PubMed PMID:33748853 .
  4. Jacob-Brassard, J, Al-Omran, M, Salata, K, Hussain, MA, Kayssi, A, Roche-Nagle, G et al.. A survey of Canadian surgeons on the indications for home care nursing following vascular surgery. Can J Surg. 2021;64 (2):E149-E154. doi: 10.1503/cjs.001220. PubMed PMID:33666391 PubMed Central PMC8064247.
  5. Gomez, D, Dossa, F, Sue-Chue-Lam, C, Wilton, AS, de Mestral, C, Urbach, D et al.. Impact of COVID 19 on the provision of surgical services in Ontario, Canada: population-based analysis. Br J Surg. 2021;108 (1):e15-e17. doi: 10.1093/bjs/znaa043. PubMed PMID:33640924 PubMed Central PMC7799281.
  6. Leung, S, Al-Omran, M, Greco, E, Qadura, M, Wheatcroft, M, Mamdani, M et al.. Monitoring the evolving impact of COVID-19 on institutional surgical services: imperative for quality improvement platforms. Br J Surg. 2021;108 (1):e7-e8. doi: 10.1093/bjs/znaa016. PubMed PMID:33640919 PubMed Central PMC7799285.
  7. de Mestral, C, Hussain, MA, Austin, PC, Forbes, TL, Sivaswamy, A, Kayssi, A et al.. Regional health care services and rates of lower extremity amputation related to diabetes and peripheral artery disease: an ecological study. CMAJ Open. ;8 (4):E659-E666. doi: 10.9778/cmajo.20200048. PubMed PMID:33109531 PubMed Central PMC7595755.
  8. Rocha, RV, De Mestral, C, Tam, DY, Lee, DS, Al-Omran, M, Austin, PC et al.. Health care costs of endovascular compared with open thoracoabdominal aortic aneurysm repair. J Vasc Surg. 2020; :. doi: 10.1016/j.jvs.2020.09.034. PubMed PMID:33098943 .
  9. Khan, H, Gallant, R, Jain, S, Al-Omran, M, De Mestral, C, Greco, E et al.. Ticagrelor as an Alternative Antiplatelet Therapy in Cardiac Patients Non-Sensitive to Aspirin. Medicina (Kaunas). 2020;56 (10):. doi: 10.3390/medicina56100519. PubMed PMID:33023261 PubMed Central PMC7600331.
  10. Salata, K, Almaghlouth, I, Hussain, MA, de Mestral, C, Greco, E, Aljabri, BA et al.. Outcomes of abdominal aortic aneurysm repair among patients with rheumatoid arthritis. J Vasc Surg. 2021;73 (4):1261-1268.e5. doi: 10.1016/j.jvs.2020.08.134. PubMed PMID:32950628 .
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Affiliations & Other Activities

  • Surgeon, Division of Vascular Surgery, St. Michael’s Hospital
  • Assistant Professor, Department of Surgery, University of Toronto
  • Adjunct Scientist, Institute for Clinical Evaluative Sciences