Claudia dos Santos

MD, MSc, BSc

Scientist

Biography

My major research interest is in acute lung injury, which can be caused by either biomolecular or biophysical insults to the lungs, such as an infection or the mechanical injury resulting from mechanical ventilation itself. My lab is dedicated to understanding the interaction between patients and the breathing machine and finding new ways to identify individuals who are at higher risk for developing lung injury, in addition to diagnosing, treating and monitoring improvement from injury. To accomplish our goals, we have developed various model systems from basic epithelial cell stretch models to animal models of lung injury. We exploit whole genome approaches, such as microarray technology, to identify novel molecular targets and use various computational strategies to analyze our data. We are also interested in understanding how and why critically ill patients develop multi-organ failure. To answer some of the more complex questions, my lab also collaborates actively with clinical researchers involved in state of the art clinical trials related to novel mechanical ventilation strategies.

Recent Publications

  1. Soussi, S, Sharma, D, Jüni, P, Lebovic, G, Brochard, L, Marshall, JC et al.. Identifying clinical subtypes in sepsis-survivors with different one-year outcomes: a secondary latent class analysis of the FROG-ICU cohort. Crit Care. 2022;26 (1):114. doi: 10.1186/s13054-022-03972-8. PubMed PMID:35449071 PubMed Central PMC9022336.
  2. Gustafson, D, Ngai, M, Wu, R, Hou, H, Schoffel, AC, Erice, C et al.. Cardiovascular signatures of COVID-19 predict mortality and identify barrier stabilizing therapies. EBioMedicine. 2022;78 :103982. doi: 10.1016/j.ebiom.2022.103982. PubMed PMID:35405523 PubMed Central PMC8989492.
  3. Walsh, CJ, Escudero King, C, Gupta, M, Plant, PJ, Herridge, MJ, Mathur, S et al.. MicroRNA regulatory networks associated with abnormal muscle repair in survivors of critical illness. J Cachexia Sarcopenia Muscle. 2022;13 (2):1262-1276. doi: 10.1002/jcsm.12903. PubMed PMID:35092190 PubMed Central PMC8977950.
  4. Baghela, A, Pena, OM, Lee, AH, Baquir, B, Falsafi, R, An, A et al.. Predicting sepsis severity at first clinical presentation: The role of endotypes and mechanistic signatures. EBioMedicine. 2022;75 :103776. doi: 10.1016/j.ebiom.2021.103776. PubMed PMID:35027333 PubMed Central PMC8808161.
  5. Tsoporis, JN, Ektesabi, AM, Gupta, S, Izhar, S, Salpeas, V, Rizos, IK et al.. A longitudinal study of alterations of circulating DJ-1 and miR203a-3p in association to olanzapine medication in a sample of first episode patients with schizophrenia. J Psychiatr Res. 2022;146 :109-117. doi: 10.1016/j.jpsychires.2021.12.049. PubMed PMID:34971908 .
  6. Albaiceta, GM, Brochard, L, Dos Santos, CC, Fernández, R, Georgopoulos, D, Girard, T et al.. The central nervous system during lung injury and mechanical ventilation: a narrative review. Br J Anaesth. 2021;127 (4):648-659. doi: 10.1016/j.bja.2021.05.038. PubMed PMID:34340836 .
  7. Tsoporis, JN, Drosatos, IA, Gupta, S, Amatullah, H, Izhar, S, Dos Santos, CC et al.. Cytoprotective Mechanisms of DJ-1: Implications in Cardiac Pathophysiology. Molecules. 2021;26 (13):. doi: 10.3390/molecules26133795. PubMed PMID:34206441 PubMed Central PMC8270312.
  8. Dos Santos, CC, Amatullah, H, Vaswani, CM, Maron-Gutierrez, T, Kim, M, Mei, SHJ et al.. Mesenchymal stromal (stem) cell therapy modulates miR-193b-5p expression to attenuate sepsis-induced acute lung injury. Eur Respir J. 2022;59 (1):. doi: 10.1183/13993003.04216-2020. PubMed PMID:34112731 .
  9. Rolandsson Enes, S, Krasnodembskaya, AD, English, K, Dos Santos, CC, Weiss, DJ. Research Progress on Strategies that can Enhance the Therapeutic Benefits of Mesenchymal Stromal Cells in Respiratory Diseases With a Specific Focus on Acute Respiratory Distress Syndrome and Other Inflammatory Lung Diseases. Front Pharmacol. 2021;12 :647652. doi: 10.3389/fphar.2021.647652. PubMed PMID:33953680 PubMed Central PMC8089479.
  10. Trahtemberg, U, Fritzler, MJ, On behalf of the COVID-19 chapter of the “Longitudinal Biomarkers in Lung Injury” study group. COVID-19-associated autoimmunity as a feature of acute respiratory failure. Intensive Care Med. 2021;47 (7):801-804. doi: 10.1007/s00134-021-06408-z. PubMed PMID:33928414 PubMed Central PMC8084710.
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Clinician Scientist, Research, University of Toronto
  • Associate Professor of Medicine, Department of Medicine, University of Toronto
  • Member, Collaborative Graduate Program in Genome Biology and Bioinformatics, University of Toronto
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