David Jenkins




Educated at Oxford University, Dr. David Jenkins is currently a Professor in both the Departments of Nutritional Sciences and Medicine, Faculty of Medicine, University of Toronto, a Staff Physician in the Division of Endocrinology and Metabolism, the Director of the Clinical Nutrition and Risk Factor Modification Center, and a Scientist in the Li Ka Shing Knowledge Institute of St. Michael’s Hospital. He has served on committees in Canada and the United States that have formulated nutritional guidelines for the treatment of diabetes and recommendations for fibre and macronutrient intake (fat protein and carbohydrates) for the general population (including the Dietary Reference intake or DRIs) under the joint United States-Canada DRI system (RDAs) of the National Academy of Sciences (Washington, DC). He led the team that first defined and explored the concept of the glycemic index of foods. He was the first to demonstrate the breadth of metabolic effects of viscous soluble fiber (as found in fruit, certain beans, oats barley) on blood glucose and cholesterol lowering of relevance to prevention and treatment of diabetes and heart disease. His studies on combining cholesterol lowering food components (dietary portfolio) have been recognized as creating an effective dietary alternative to drug therapy (statins) for lower risk people. In an important study, he compared a dietary portfolio with all food provided with a statin in the same people and demonstrated that the effects of both were comparable. The dietary portfolio, on the basis of this and other studies including a major cross Canada real world study, was the only dietary approach referenced in 2004 Guidelines update of the US National Cholesterol Education Program (ATP III) and recommended in the Canadian Cardiovascular Society (CCS) guidelines for 2012 and the European Atherosclerosis Society consensus statement (2015). He has received many National and International awards in recognition of his contribution to nutrition research. He believes in the value of plant based diets, and that a major effort is required to mount large studies to determine the extent of their health benefits. He also believes that diets have to be environmentally sustainable.

Please note: Dr. Jenkins is currently accepting volunteer students.

Recent Publications

  1. Jenkins, DJA, Dehghan, M, Yusuf, S. Glycemic Index, Glycemic Load, and Cardiovascular Disease and Mortality. Reply. N Engl J Med. 2021;385 (4):379-380. doi: 10.1056/NEJMc2107926. PubMed PMID:34289286 .
  2. Ayoub-Charette, S, Chiavaroli, L, Liu, Q, Khan, TA, Zurbau, A, Au-Yeung, F et al.. Different Food Sources of Fructose-Containing Sugars and Fasting Blood Uric Acid Levels: A Systematic Review and Meta-Analysis of Controlled Feeding Trials. J Nutr. 2021; :. doi: 10.1093/jn/nxab144. PubMed PMID:34087940 .
  3. Semnani-Azad, Z, Connelly, PW, Bazinet, RP, Retnakaran, R, Jenkins, DJA, Harris, SB et al.. Adipose Tissue Insulin Resistance Is Longitudinally Associated With Adipose Tissue Dysfunction, Circulating Lipids, and Dysglycemia: The PROMISE Cohort. Diabetes Care. 2021; :. doi: 10.2337/dc20-1918. PubMed PMID:34001534 .
  4. Glenn, AJ, Hernández-Alonso, P, Kendall, CWC, Martínez-González, MÁ, Corella, D, Fitó, M et al.. Longitudinal changes in adherence to the portfolio and DASH dietary patterns and cardiometabolic risk factors in the PREDIMED-Plus study. Clin Nutr. 2021;40 (5):2825-2836. doi: 10.1016/j.clnu.2021.03.016. PubMed PMID:33933749 .
  5. Semnani-Azad, Z, Blanco Mejia, S, Connelly, PW, Bazinet, RP, Retnakaran, R, Jenkins, DJA et al.. The association of soluble CD163, a novel biomarker of macrophage activation, with type 2 diabetes mellitus and its underlying physiological disorders: A systematic review. Obes Rev. 2021; :. doi: 10.1111/obr.13257. PubMed PMID:33913230 .
  6. Nishi, SK, Kendall, CWC, Bazinet, RP, Hanley, AJ, Comelli, EM, Jenkins, DJA et al.. Almond Bioaccessibility in a Randomized Crossover Trial: Is a Calorie a Calorie?. Mayo Clin Proc. 2021; :. doi: 10.1016/j.mayocp.2021.01.026. PubMed PMID:33853731 .
  7. Mutch, DM, Lowry, DE, Roth, M, Sihag, J, Hammad, SS, Taylor, CG et al.. Polymorphisms in the stearoyl-CoA desaturase gene modify blood glucose response to dietary oils varying in MUFA content in adults with obesity. Br J Nutr. 2021; :1-10. doi: 10.1017/S0007114521001264. PubMed PMID:33829984 .
  8. Spence, JD, Srichaikul, KK, Jenkins, DJA. Cardiovascular Harm From Egg Yolk and Meat: More Than Just Cholesterol and Saturated Fat. J Am Heart Assoc. 2021;10 (7):e017066. doi: 10.1161/JAHA.120.017066. PubMed PMID:33719494 PubMed Central PMC8174346.
  9. Jenkins, DJA, Dehghan, M, Mente, A, Bangdiwala, SI, Rangarajan, S, Srichaikul, K et al.. Glycemic Index, Glycemic Load, and Cardiovascular Disease and Mortality. N Engl J Med. 2021;384 (14):1312-1322. doi: 10.1056/NEJMoa2007123. PubMed PMID:33626252 .
  10. Swaminathan, S, Dehghan, M, Raj, JM, Thomas, T, Rangarajan, S, Jenkins, D et al.. Associations of cereal grains intake with cardiovascular disease and mortality across 21 countries in Prospective Urban and Rural Epidemiology study: prospective cohort study. BMJ. 2021;372 :m4948. doi: 10.1136/bmj.m4948. PubMed PMID:33536317 PubMed Central PMC7856570.
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Affiliations & Other Activities

  • Director, Clinical Nutrition and Risk Factor Modification Centre, St. Michael’s Hospital
  • Staff Physician, Division of Endocrinology, Department of Medicine, St. Michael’s Hospital
  • Professor and Canada Research Chair in Nutrition and Metabolism, Dept. of Medicine and Nutritional Sciences, Faculty of Medicine, University of Toronto
  • Canada Research Chair in Nutrition and Metabolism