David Klein




My research follows two major themes: (1) health policy and (2) sepsis and critical illness.   In the area of health policy, I co-lead the Centre for the Evaluation and Optimization of Public Healthcare Finance at IHPME with Dr. Adalsteinn Brown.  We are focused on improving healthcare capital investment and evaluation with a multidisciplinary group of collaborators.   In the area of sepsis and critical illness, I lead several efforts to develop novel diagnostics and therapeutics.  I have particular expertise in healthcare innovation and commercialization in addition to clinical development strategy.

Please note: Dr. Klein is not taking any summer students.

Recent Publications

  1. Brauer, P, Royall, D, Li, A, Rodrigues, A, Green, J, Macklin, S et al.. Key process features of personalized diet counselling in metabolic syndrome: secondary analysis of feasibility study in primary care. BMC Nutr. 2022;8 (1):45. doi: 10.1186/s40795-022-00540-9. PubMed PMID:35534841 PubMed Central PMC9081667.
  2. Kashef Al-Ghetaa, R, Daniel, I, Shaw, J, Klein, D, Brown, A. The determinants of effective inter-organization information sharing in the health capital planning process. Healthc Manage Forum. 2022;35 (4):236-242. doi: 10.1177/08404704221087408. PubMed PMID:35507410 .
  3. Brauer, P, Desroches, S, Dhaliwal, R, Li, A, Wang, Y, Conklin, AI et al.. Modified Delphi Process to Identify Research Priorities and Measures for Adult Lifestyle Programs to Address Type 2 Diabetes and Other Cardiometabolic Risk Conditions. Can J Diabetes. 2022; :. doi: 10.1016/j.jcjd.2022.01.003. PubMed PMID:35484054 .
  4. REMAP-CAP Writing Committee for the REMAP-CAP Investigators, Bradbury, CA, Lawler, PR, Stanworth, SJ, McVerry, BJ, McQuilten, Z et al.. Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial. JAMA. 2022;327 (13):1247-1259. doi: 10.1001/jama.2022.2910. PubMed PMID:35315874 PubMed Central PMC8941448.
  5. Maitland, SB, Brauer, P, Mutch, DM, Royall, D, Klein, D, Tremblay, A et al.. Evaluation of Latent Models Assessing Physical Fitness and the Healthy Eating Index in Community Studies: Time-, Sex-, and Diabetes-Status Invariance. Nutrients. 2021;13 (12):. doi: 10.3390/nu13124258. PubMed PMID:34959810 PubMed Central PMC8708138.
  6. Freudenberg, N, Lee, K, Buse, K, Collin, J, Crosbie, E, Friel, S et al.. Defining Priorities for Action and Research on the Commercial Determinants of Health: A Conceptual Review. Am J Public Health. 2021;111 (12):2202-2211. doi: 10.2105/AJPH.2021.306491. PubMed PMID:34878875 PubMed Central PMC8667845.
  7. Lee, K, Freudenberg, N, Zenone, M, Smith, J, Mialon, M, Marten, R et al.. Measuring the Commercial Determinants of Health and Disease: A Proposed Framework. Int J Health Serv. 2022;52 (1):115-128. doi: 10.1177/00207314211044992. PubMed PMID:34723675 PubMed Central PMC8592108.
  8. Klein, DE, Lima, JM. The Prison Industrial Complex as a Commercial Determinant of Health. Am J Public Health. 2021;111 (10):1750-1752. doi: 10.2105/AJPH.2021.306467. PubMed PMID:34529500 PubMed Central PMC8561192.
  9. REMAP-CAP Investigators, ACTIV-4a Investigators, ATTACC Investigators, Goligher, EC, Bradbury, CA, McVerry, BJ et al.. Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19. N Engl J Med. 2021;385 (9):777-789. doi: 10.1056/NEJMoa2103417. PubMed PMID:34351722 PubMed Central PMC8362592.
  10. ATTACC Investigators, ACTIV-4a Investigators, REMAP-CAP Investigators, Lawler, PR, Goligher, EC, Berger, JS et al.. Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19. N Engl J Med. 2021;385 (9):790-802. doi: 10.1056/NEJMoa2105911. PubMed PMID:34351721 PubMed Central PMC8362594.
Search PubMed

Affiliations & Other Activities

  • Head of Business Strategy, Applied Health Research Centre, Li Ka Shing Knowledge Institute, St. Michael’s Hospital
  • Staff Physician, Critical Care, St. Michael’s Hospital
  • Assistant Professor, Faculty of Medicine, University of Toronto
  • Member, Institute for Health Policy, Management, and Evaluation, Dalla Lana School of Public Health