David Munoz



Research Programs


Dr. David Munoz holds an MD from Navarre and MSc in Pathology from Queen’s University, Ontario. He trained in neurology and neuropathology and became a Fellow of the Royal College of Physicians and Surgeons of Canada in 1984. He has practiced in Vermont, Saskatoon, London (ON), Madrid, and Toronto, and briefly in Vancouver. He is currently a Neuropathologist and Head, Division of Pathology at St. Michael’s Hospital, Toronto, and Professor, Department of Laboratory Medicine and Pathobiology, University of Toronto. He is the author of 194 peer-reviewed papers, 20 book chapters, and co-author of one book. He has held research grants in Canada (Medical Research Council and Canadian Institutes of Health Research) and USA (National Institutes of Health).

His research interest is focused on neuropathology, particularly the mechanisms of development and progression of degenerative diseases of the brain, including Alzheimer’s disease, the non-Alzheimer dementias, movement disorders, and amyotrophic lateral sclerosis. His other research interest in neurooncology is derived from his clinical practice.

Please note: Dr. D. Munoz is not taking any summer students

Recent Publications

  1. Ahangari, N, Munoz, DG, Coulombe, J, Gray, DA, Engle, EC, Cheng, L et al.. Nuclear IMPDH Filaments in Human Gliomas. J Neuropathol Exp Neurol. 2021; :. doi: 10.1093/jnen/nlab090. PubMed PMID:34498062 .
  2. Davidson, B, Narvacan, K, Munoz, DG, Rotondo, F, Kovacs, K, Zhang, S et al.. The Crucial Role of Eosinophils in the Life Cycle, Radiographical Architecture, and Risk of Recurrence of Chronic Subdural Hematomas. Neurotrauma Rep. 2021;2 (1):76-83. doi: 10.1089/neur.2020.0036. PubMed PMID:34223547 PubMed Central PMC8240825.
  3. Ramirez, J, Holmes, MF, Berezuk, C, Kwan, D, Tan, B, Beaton, D et al.. MRI-visible perivascular space volumes, sleep duration and daytime dysfunction in adults with cerebrovascular disease. Sleep Med. 2021;83 :83-88. doi: 10.1016/j.sleep.2021.03.043. PubMed PMID:33991894 .
  4. Maralani, PJ, Myrehaug, S, Mehrabian, H, Chan, AK, Wintermark, M, Heyn, C et al.. ADC, D, f dataset calculated through the simplified IVIM model, with MGMT promoter methylation, age, and ECOG, in 38 patients with wildtype IDH glioblastoma. Data Brief. 2021;35 :106950. doi: 10.1016/j.dib.2021.106950. PubMed PMID:33850982 PubMed Central PMC8039816.
  5. Gilani, K, Kuntz, S, Munoz, DG, Schneider, R. Pearls & Oy-sters: Rosai-Dorfman Disease of the Central Nervous System. Neurology. 2021; :. doi: 10.1212/WNL.0000000000012035. PubMed PMID:33849989 .
  6. Karameh, WK, Kortebi, I, Kumar, S, Gallagher, D, Golas, A, Lanctôt, KL et al.. Comparing cardiovascular risk factors in older persons with mild cognitive impairment and lifetime history of major depressive disorder. Int Psychogeriatr. 2021; :1-7. doi: 10.1017/S1041610221000259. PubMed PMID:33775259 .
  7. Jabehdar Maralani, P, Myrehaug, S, Mehrabian, H, Chan, AKM, Wintermark, M, Heyn, C et al.. Intravoxel incoherent motion (IVIM) modeling of diffusion MRI during chemoradiation predicts therapeutic response in IDH wildtype glioblastoma. Radiother Oncol. 2021;156 :258-265. doi: 10.1016/j.radonc.2020.12.037. PubMed PMID:33418005 PubMed Central PMC8186561.
  8. Liu, C, Daigle, P, Munoz, DG, Nijhawan, N. Intravascular Papillary Endothelial Hyperplasia as a Cause of Reversible Vision Loss. J Craniofac Surg. 2020; :. doi: 10.1097/SCS.0000000000007271. PubMed PMID:33235177 .
  9. Muir, RT, Suthiphosuwan, S, Bharatha, A, Lin, A, Munoz, D, Ostrowski, M et al.. Reversible Small Vessel Vasculitis and Encephalitis in HIV Antiretroviral Resistance. J Neuropathol Exp Neurol. 2021;80 (1):89-92. doi: 10.1093/jnen/nlaa106. PubMed PMID:33212472 PubMed Central PMC7749715.
  10. Rozitis, B, Ryan, AJ, Emery, JP, Christensen, PR, Hamilton, VE, Simon, AA et al.. Asteroid (101955) Bennu's weak boulders and thermally anomalous equator. Sci Adv. 2020;6 (41):. doi: 10.1126/sciadv.abc3699. PubMed PMID:33033037 PubMed Central PMC7544501.
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Affiliations & Other Activities

  • Head, Division of Pathology, St. Michael’s Hospital
  • Professor, Laboratory Medicine and Pathobiology, University of Toronto