Jan O. Friedrich

MD, PhD, MSc



I have an interest in clinical epidemiologic techniques to evaluate the effectiveness of therapies in critical care. Current areas of interest include use and development of meta-analytic techniques, evaluation of treatments to treat acute lung injury, septic shock, and acute renal failure in intensive care unit patients.

Please note: Dr. Friedrich is not taking any summer students.

Recent Publications

  1. Dhanani, S, Hornby, L, van Beinum, A, Scales, NB, Hogue, M, Baker, A et al.. Resumption of Cardiac Activity after Withdrawal of Life-Sustaining Measures. N Engl J Med. 2021;384 (4):345-352. doi: 10.1056/NEJMoa2022713. PubMed PMID:33503343 .
  2. Bodley, T, Chan, M, Levi, O, Clarfield, L, Yip, D, Smith, O et al.. Patient harm associated with serial phlebotomy and blood waste in the intensive care unit: A retrospective cohort study. PLoS One. 2021;16 (1):e0243782. doi: 10.1371/journal.pone.0243782. PubMed PMID:33439871 PubMed Central PMC7806151.
  3. Sklar, MC, Madotto, F, Jonkman, A, Rauseo, M, Soliman, I, Damiani, LF et al.. Duration of diaphragmatic inactivity after endotracheal intubation of critically ill patients. Crit Care. 2021;25 (1):26. doi: 10.1186/s13054-020-03435-y. PubMed PMID:33430930 PubMed Central PMC7798017.
  4. Sud, S, Friedrich, JO, Adhikari, NK, Fan, E, Ferguson, ND, Guyatt, G et al.. Comparative Effectiveness of Protective Ventilation Strategies for Moderate and Severe ARDS: Network Meta-Analysis. Am J Respir Crit Care Med. 2021; :. doi: 10.1164/rccm.202008-3039OC. PubMed PMID:33406009 .
  5. Harvey, AK, Burns, KEA, McArthur, E, Adhikari, NKJ, Li, D, Kitchlu, A et al.. Short-and long-term outcomes of sustained low efficiency dialysis vs continuous renal replacement therapy in critically ill patients with acute kidney injury. J Crit Care. 2021;62 :76-81. doi: 10.1016/j.jcrc.2020.11.003. PubMed PMID:33290929 .
  6. Lee, JJ, Ha, ACT, Dorian, P, Verma, M, Goodman, SG, Friedrich, JO et al.. Meta-Analysis of Safety and Efficacy of Direct Oral Anticoagulants Versus Warfarin According to Time in Therapeutic Range in Atrial Fibrillation. Am J Cardiol. 2021;140 :62-68. doi: 10.1016/j.amjcard.2020.10.064. PubMed PMID:33189659 .
  7. Hare, GMT, Cazorla-Bak, MP, Ku, SFM, Chin, K, Mistry, N, Sklar, MC et al.. When to transfuse your acute care patient? A narrative review of the risk of anemia and red blood cell transfusion based on clinical trial outcomes. Can J Anaesth. 2020;67 (11):1576-1594. doi: 10.1007/s12630-020-01763-9. PubMed PMID:32770311 .
  8. Wilcox, ME, McAndrews, MP, Van, J, Jackson, JC, Pinto, R, Black, SE et al.. Sleep Fragmentation and Cognitive Trajectories After Critical Illness. Chest. 2021;159 (1):366-381. doi: 10.1016/j.chest.2020.07.036. PubMed PMID:32717265 .
  9. STARRT-AKI Investigators, Canadian Critical Care Trials Group, Australian and New Zealand Intensive Care Society Clinical Trials Group, United Kingdom Critical Care Research Group, Canadian Nephrology Trials Network, Irish Critical Care Trials Group et al.. Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury. N Engl J Med. 2020;383 (3):240-251. doi: 10.1056/NEJMoa2000741. PubMed PMID:32668114 .
  10. Smith, OM, Metcalfe, K, Puts, M, McDonald, E, Sue-Chee, S, Friedrich, JO et al.. Role Incongruence and Psychological Stress Symptoms in Substitute Decision Makers of Intensive Care Patients. Am J Crit Care. 2020;29 (4):301-310. doi: 10.4037/ajcc2020307. PubMed PMID:32607568 .
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Affiliations & Other Activities

  • Medical Director, Medical-Surgical Intensive Care Unit (MSICU), Critical Care and Medicine Departments, St. Michael’s Hospital
  • Associate Professor, Medicine and Interdepartmental Division of Critical Care, University of Toronto