Jan O. Friedrich

MD, PhD, MSc



I have an interest in clinical epidemiologic techniques to evaluate the effectiveness of therapies in critical care. Current areas of interest include use and development of meta-analytic techniques, evaluation of treatments to treat acute lung injury, septic shock, and acute renal failure in intensive care unit patients.

Please note: Dr. Friedrich is not taking any summer students.

Recent Publications

  1. Johnstone, J, Meade, M, Lauzier, F, Marshall, J, Duan, E, Dionne, J et al.. Effect of Probiotics on Incident Ventilator-Associated Pneumonia in Critically Ill Patients: A Randomized Clinical Trial. JAMA. 2021;326 (11):1024-1033. doi: 10.1001/jama.2021.13355. PubMed PMID:34546300 .
  2. Mehta, S, Zhou, Q, Pinto, R, Friedrich, JO, Lamontagne, F, Ferguson, ND et al.. Utilization and effect of neuromuscular blockade in a randomized trial of high-frequency oscillation. J Crit Care. 2021;66 :86-92. doi: 10.1016/j.jcrc.2021.08.006. PubMed PMID:34474282 .
  3. Trivedi, V, Chaudhuri, D, Jinah, R, Piticaru, J, Agarwal, A, Liu, K et al.. The Usefulness of the Rapid Shallow Breathing Index in Predicting Successful Extubation: A Systematic Review and Meta-analysis. Chest. 2021; :. doi: 10.1016/j.chest.2021.06.030. PubMed PMID:34181953 .
  4. Lee, JA, Yanagawa, B, An, KR, Arora, RC, Verma, S, Friedrich, JO et al.. Frailty and pre-frailty in cardiac surgery: a systematic review and meta-analysis of 66,448 patients. J Cardiothorac Surg. 2021;16 (1):184. doi: 10.1186/s13019-021-01541-8. PubMed PMID:34172059 PubMed Central PMC8229742.
  5. Beaubien-Souligny, W, Yang, Y, Burns, KEA, Friedrich, JO, Meraz-Muñoz, A, Clark, EG et al.. Intra-dialytic hypotension following the transition from continuous to intermittent renal replacement therapy. Ann Intensive Care. 2021;11 (1):96. doi: 10.1186/s13613-021-00885-7. PubMed PMID:34146164 PubMed Central PMC8214642.
  6. Tejerina, EE, Pelosi, P, Robba, C, Peñuelas, O, Muriel, A, Barrios, D et al.. Evolution Over Time of Ventilatory Management and Outcome of Patients With Neurologic Disease. Crit Care Med. 2021;49 (7):1095-1106. doi: 10.1097/CCM.0000000000004921. PubMed PMID:33729719 .
  7. Dhanani, S, Hornby, L, van Beinum, A, Scales, NB, Hogue, M, Baker, A et al.. Resumption of Cardiac Activity after Withdrawal of Life-Sustaining Measures. N Engl J Med. 2021;384 (4):345-352. doi: 10.1056/NEJMoa2022713. PubMed PMID:33503343 .
  8. Bodley, T, Chan, M, Levi, O, Clarfield, L, Yip, D, Smith, O et al.. Patient harm associated with serial phlebotomy and blood waste in the intensive care unit: A retrospective cohort study. PLoS One. 2021;16 (1):e0243782. doi: 10.1371/journal.pone.0243782. PubMed PMID:33439871 PubMed Central PMC7806151.
  9. Sklar, MC, Madotto, F, Jonkman, A, Rauseo, M, Soliman, I, Damiani, LF et al.. Duration of diaphragmatic inactivity after endotracheal intubation of critically ill patients. Crit Care. 2021;25 (1):26. doi: 10.1186/s13054-020-03435-y. PubMed PMID:33430930 PubMed Central PMC7798017.
  10. Sud, S, Friedrich, JO, Adhikari, NKJ, Fan, E, Ferguson, ND, Guyatt, G et al.. Comparative Effectiveness of Protective Ventilation Strategies for Moderate and Severe Acute Respiratory Distress Syndrome. A Network Meta-Analysis. Am J Respir Crit Care Med. 2021;203 (11):1366-1377. doi: 10.1164/rccm.202008-3039OC. PubMed PMID:33406009 .
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Affiliations & Other Activities

  • Medical Director, Medical-Surgical Intensive Care Unit (MSICU), Critical Care and Medicine Departments, St. Michael’s Hospital
  • Associate Professor, Medicine and Interdepartmental Division of Critical Care, University of Toronto