Jane Batt

MD, PhD

Scientist

Biography

Dr. Jane Batt is a Respirologist and Scientist at St. Michael’s Hospital and Associate Professor of Medicine, University of Toronto. Her research focuses on delineating the molecular mechanisms underlying the development of skeletal muscle atrophy and dysfunction in chronic respiratory illness and acute injury. Examples of current projects in the lab include 1) MEND-ICU – a study of  the molecular mechanisms underpinning  Intensive Care Unit Acquired Weakness (ICUAW), a complication of critical care that results in lifelong disability due to sustained muscle wasting and contractile dysfunction 2) the development of “Smart Garments” (arm sleeves and leg stockings) that will automate the delivery of neuromuscular electrical stimulation (NMES) therapy to ICU patients using artificial intelligence/machine learning techniques, to prevent ICUAW and 3) applying ultrasound mediated gene delivery (UMGD) to promote the repair and regeneration of denervated muscle and sustain its receptivity to reinnervation.  Working in a rat model of tibial nerve transection, genes in minicircle plasmids coupled to carrier microbubbles are systemically administered, and directed to induce muscle specific transfection and temporary (6-8 week) gene expression by high-power ultrasound mediated microbubble destruction over the target tissue.

Dr Batt is also the Medical Director of the SMH Tuberculosis (TB) Clinic and in collaboration with other SMH scientists is developing a digital database of all patients seen in the TB clinic to enable collaborative clinical research projects. The database consists of variables (clinical, demographic, imaging, lab values, visits/admissions) that are derived from clinical dictations using natural language processing tools and electronic medical records, with digital dashboard navigation capabilities.

Dr. Batt’s research is consistently awarded peer-review funding including grants from the Canadian Institutes of Health Research (CIHR), OLA/Ontario Thoracic Society, New Frontiers in Research-Exploration and Physician Services Incorporation. She has served on several hospital and University of Toronto advisory committees and is Chair, Division of Respirology Research Advisory Committee (2014 – present).

Recent Publications

  1. Tran, A, Walsh, CJ, Batt, J, Dos Santos, CC, Hu, P. A machine learning-based clinical tool for diagnosing myopathy using multi-cohort microarray expression profiles. J Transl Med. 2020;18 (1):454. doi: 10.1186/s12967-020-02630-3. PubMed PMID:33256785 PubMed Central PMC7708151.
  2. Lad, H, Saumur, TM, Herridge, MS, Dos Santos, CC, Mathur, S, Batt, J et al.. Intensive Care Unit-Acquired Weakness: Not just Another Muscle Atrophying Condition. Int J Mol Sci. 2020;21 (21):. doi: 10.3390/ijms21217840. PubMed PMID:33105809 PubMed Central PMC7660068.
  3. Gupta, S, Batt, J, Bourbeau, J, Chapman, KR, Gershon, A, Granton, J et al.. Triaging Access to Critical Care Resources in Patients With Chronic Respiratory Diseases in the Event of a Major COVID-19 Surge: Key Highlights From the Canadian Thoracic Society (CTS) Position Statement. Chest. 2020;158 (6):2270-2274. doi: 10.1016/j.chest.2020.07.018. PubMed PMID:32693101 PubMed Central PMC7368654.
  4. Binnie, A, Walsh, CJ, Hu, P, Dwivedi, DJ, Fox-Robichaud, A, Liaw, PC et al.. Epigenetic Profiling in Severe Sepsis: A Pilot Study of DNA Methylation Profiles in Critical Illness. Crit Care Med. 2020;48 (2):142-150. doi: 10.1097/CCM.0000000000004097. PubMed PMID:31939781 .
  5. Petch, J, Batt, J, Murray, J, Mamdani, M. Extracting Clinical Features From Dictated Ambulatory Consult Notes Using a Commercially Available Natural Language Processing Tool: Pilot, Retrospective, Cross-Sectional Validation Study. JMIR Med Inform. 2019;7 (4):e12575. doi: 10.2196/12575. PubMed PMID:31682579 PubMed Central PMC6913750.
  6. Batt, J, Herridge, MS, Dos Santos, CC. From skeletal muscle weakness to functional outcomes following critical illness: a translational biology perspective. Thorax. 2019;74 (11):1091-1098. doi: 10.1136/thoraxjnl-2016-208312. PubMed PMID:31431489 .
  7. Batt, J, Khan, K. Responsible use of rifampin for the treatment of latent tuberculosis infection. CMAJ. 2019;191 (25):E678-E679. doi: 10.1503/cmaj.190081. PubMed PMID:31235488 PubMed Central PMC6592804.
  8. Hamilton, M, Tomlinson, G, Chu, L, Robles, P, Matte, A, Burns, S et al.. Determinants of Depressive Symptoms at 1 Year Following ICU Discharge in Survivors of ≥ 7 Days of Mechanical Ventilation: Results From the RECOVER Program, a Secondary Analysis of a Prospective Multicenter Cohort Study. Chest. 2019;156 (3):466-476. doi: 10.1016/j.chest.2019.04.104. PubMed PMID:31102611 .
  9. Parotto, M, Batt, J, Herridge, M. The Pathophysiology of Neuromuscular Dysfunction in Critical Illness. Crit Care Clin. 2018;34 (4):549-556. doi: 10.1016/j.ccc.2018.06.010. PubMed PMID:30223993 .
  10. Chien, K, Seemangal, J, Batt, J, Vozoris, NT. Abdominal tuberculosis: a descriptive case series of the experience in a Canadian tuberculosis clinic. Int J Tuberc Lung Dis. 2018;22 (6):681-685. doi: 10.5588/ijtld.17.0685. PubMed PMID:29862954 .
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Affiliations & Other Activities

  • Respirologist and Clinician Scientist, Division of Respirology, Department of Medicine, St. Michael’s Hospital
  • Medical Director, Tuberculosis Program, St. Michael’s Hospital
  • Associate Professor, Faculty of Medicine, University of Toronto
  • Cross appointed to the to the IDCCM
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