John Laffey


Affiliate Scientist


Dr. Laffey is Anesthesiologist-in-Chief at St Michael’s Hospital, Toronto, Co-Director of the Critical Illness and Injury Research Centre at the Keenan Research Centre, St. Michael’s hospital. He is a Clinician Scientist at the Keenan Research Centre, and Professor of Anesthesia, Critical Care and Physiology at the University of Toronto. His research is focused on ARDS, particularly the mechanisms underlying ventilation induced lung injury. He has a longstanding interest in the effects and mechanisms of hypercapnic acidosis in ARDS and sepsis. His current research focus is the investigation of the therapeutic potential of cell therapies for ARDS.

Recent Publications

  1. Masterson, C, Horie, S, McCarthy, SD, Gonzalez, H, Byrnes, D, Brady, J et al.. Hypercapnia in the critically ill: insights from the bench to the bedside. Interface Focus. 2021;11 (2):20200032. doi: 10.1098/rsfs.2020.0032. PubMed PMID:33628425 PubMed Central PMC7898152.
  2. Rekanar, K, O'Keeffe, IR, Buckley, S, Abbas, M, Beecham, S, Chochlov, M et al.. Sentiment analysis of user feedback on the HSE's Covid-19 contact tracing app. Ir J Med Sci. 2021; :. doi: 10.1007/s11845-021-02529-y. PubMed PMID:33604836 PubMed Central PMC7891483.
  3. Bos, LDJ, Artigas, A, Constantin, JM, Hagens, LA, Heijnen, N, Laffey, JG et al.. Precision medicine in acute respiratory distress syndrome: workshop report and recommendations for future research. Eur Respir Rev. 2021;30 (159):. doi: 10.1183/16000617.0317-2020. PubMed PMID:33536264 .
  4. Clarke, J, Geoghegan, P, McEvoy, N, Boylan, M, Ní Choileáin, O, Mulligan, M et al.. Prone positioning improves oxygenation and lung recruitment in patients with SARS-CoV-2 acute respiratory distress syndrome; a single centre cohort study of 20 consecutive patients. BMC Res Notes. 2021;14 (1):20. doi: 10.1186/s13104-020-05426-2. PubMed PMID:33422143 PubMed Central PMC7796647.
  5. van Haren, FMP, Richardson, A, Yoon, HJ, Artigas, A, Laffey, JG, Dixon, B et al.. INHALEd nebulised unfractionated HEParin for the treatment of hospitalised patients with COVID-19 (INHALE-HEP): Protocol and statistical analysis plan for an investigator-initiated international metatrial of randomised studies. Br J Clin Pharmacol. 2020; :. doi: 10.1111/bcp.14714. PubMed PMID:33377218 .
  6. Brady, J, Horie, S, Laffey, JG. Role of the adaptive immune response in sepsis. Intensive Care Med Exp. 2020;8 (Suppl 1):20. doi: 10.1186/s40635-020-00309-z. PubMed PMID:33336293 PubMed Central PMC7746432.
  7. Pham, T, Pesenti, A, Bellani, G, Rubenfeld, G, Fan, E, Bugedo, G et al.. Outcome of Acute Hypoxaemic Respiratory Failure. Insights from the Lung Safe Study. Eur Respir J. 2020; :. doi: 10.1183/13993003.03317-2020. PubMed PMID:33334944 .
  8. McGinn, R, Fergusson, DA, Stewart, DJ, Kristof, AS, Barron, CC, Thebaud, B et al.. Surrogate Humane Endpoints in Small Animal Models of Acute Lung Injury: A Modified Delphi Consensus Study of Researchers and Laboratory Animal Veterinarians. Crit Care Med. 2021;49 (2):311-323. doi: 10.1097/CCM.0000000000004734. PubMed PMID:33332817 .
  9. Murphy, EJ, Rezoagli, E, Major, I, Rowan, NJ, Laffey, JG. β-Glucan Metabolic and Immunomodulatory Properties and Potential for Clinical Application. J Fungi (Basel). 2020;6 (4):. doi: 10.3390/jof6040356. PubMed PMID:33322069 PubMed Central PMC7770584.
  10. Gonzalez, H, Horie, S, Laffey, JG. Emerging cellular and pharmacologic therapies for acute respiratory distress syndrome. Curr Opin Crit Care. 2021;27 (1):20-28. doi: 10.1097/MCC.0000000000000784. PubMed PMID:33278121 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Chief, Department of Anesthesia, St. Michael’s Hospital
  • Professor, Anesthesia, Critical Care, and Physiology, University of Toronto