John Laffey


Affiliate Scientist


Dr. Laffey is Anesthesiologist-in-Chief at St Michael’s Hospital, Toronto, Co-Director of the Critical Illness and Injury Research Centre at the Keenan Research Centre, St. Michael’s hospital. He is a Clinician Scientist at the Keenan Research Centre, and Professor of Anesthesia, Critical Care and Physiology at the University of Toronto. His research is focused on ARDS, particularly the mechanisms underlying ventilation induced lung injury. He has a longstanding interest in the effects and mechanisms of hypercapnic acidosis in ARDS and sepsis. His current research focus is the investigation of the therapeutic potential of cell therapies for ARDS.

Recent Publications

  1. Flynn, J, O'Connor, L, Hanlon, M, Bellani, G, Contreras, M, Doherty, A et al.. The identification of needs and development of best practice guidance for the psychological support of frontline healthcare workers during and after COVID-19: A protocol for the FLoWS project. HRB Open Res. 2020;3 :54. doi: 10.12688/hrbopenres.13117.2. PubMed PMID:33870088 PubMed Central PMC8030118.
  2. McEvoy, NL, Clarke, JL, Mc Elvaney, OJ, Mc Elvaney, OF, Boland, F, Hyland, D et al.. A randomised, double-blind, placebo-controlled, pilot trial of intravenous plasma purified alpha-1 antitrypsin for SARS-CoV-2-induced Acute Respiratory Distress Syndrome: a structured summary of a study protocol for a randomised, controlled trial. Trials. 2021;22 (1):288. doi: 10.1186/s13063-021-05254-0. PubMed PMID:33874981 PubMed Central PMC8054126.
  3. Madotto, F, McNicholas, B, Rezoagli, E, Pham, T, Laffey, JG, Bellani, G et al.. Death in hospital following ICU discharge: insights from the LUNG SAFE study. Crit Care. 2021;25 (1):144. doi: 10.1186/s13054-021-03465-0. PubMed PMID:33849625 PubMed Central PMC8043098.
  4. Simon, P, Girrbach, F, Petroff, D, Schliewe, N, Hempel, G, Lange, M et al.. Individualized versus Fixed Positive End-expiratory Pressure for Intraoperative Mechanical Ventilation in Obese Patients: A Secondary Analysis. Anesthesiology. 2021;134 (6):887-900. doi: 10.1097/ALN.0000000000003762. PubMed PMID:33843980 .
  5. Jerkic, M, Litvack, ML, Gagnon, S, Otulakowski, G, Zhang, H, Rotstein, O et al.. Embryonic-Derived Myb- Macrophages Enhance Bacterial Clearance and Improve Survival in Rat Sepsis. Int J Mol Sci. 2021;22 (6):. doi: 10.3390/ijms22063190. PubMed PMID:33804806 PubMed Central PMC8004006.
  6. Russotto, V, Myatra, SN, Laffey, JG, Tassistro, E, Antolini, L, Bauer, P et al.. Intubation Practices and Adverse Peri-intubation Events in Critically Ill Patients From 29 Countries. JAMA. 2021;325 (12):1164-1172. doi: 10.1001/jama.2021.1727. PubMed PMID:33755076 PubMed Central PMC7988368.
  7. Dumas, G, Lemiale, V, Rathi, N, Cortegiani, A, Pène, F, Bonny, V et al.. Survival in Immunocompromised Patients Ultimately Requiring Invasive Mechanical Ventilation: A Pooled Individual Patient Data Analysis. Am J Respir Crit Care Med. 2021; :. doi: 10.1164/rccm.202009-3575OC. PubMed PMID:33751920 .
  8. Stilma, W, Åkerman, E, Artigas, A, Bentley, A, Bos, LD, Bosman, TJC et al.. Awake Proning as an Adjunctive Therapy for Refractory Hypoxemia in Non-Intubated Patients with COVID-19 Acute Respiratory Failure: Guidance from an International Group of Healthcare Workers. Am J Trop Med Hyg. 2021; :. doi: 10.4269/ajtmh.20-1445. PubMed PMID:33705348 PubMed Central PMC8103477.
  9. McDonnell, MJ, Hunt, EB, Ward, C, Pearson, JP, O'Toole, D, Laffey, JG et al.. Current therapies for gastro-oesophageal reflux in the setting of chronic lung disease: state of the art review. ERJ Open Res. 2020;6 (4):. doi: 10.1183/23120541.00190-2019. PubMed PMID:33693049 PubMed Central PMC7927787.
  10. Masterson, CH, Tabuchi, A, Hogan, G, Fitzpatrick, G, Kerrigan, SW, Jerkic, M et al.. Intra-vital imaging of mesenchymal stromal cell kinetics in the pulmonary vasculature during infection. Sci Rep. 2021;11 (1):5265. doi: 10.1038/s41598-021-83894-7. PubMed PMID:33664277 PubMed Central PMC7933415.
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Chief, Department of Anesthesia, St. Michael’s Hospital
  • Professor, Anesthesia, Critical Care, and Physiology, University of Toronto