John Laffey


Affiliate Scientist


Dr. Laffey is Anesthesiologist-in-Chief at St Michael’s Hospital, Toronto, Co-Director of the Critical Illness and Injury Research Centre at the Keenan Research Centre, St. Michael’s hospital. He is a Clinician Scientist at the Keenan Research Centre, and Professor of Anesthesia, Critical Care and Physiology at the University of Toronto. His research is focused on ARDS, particularly the mechanisms underlying ventilation induced lung injury. He has a longstanding interest in the effects and mechanisms of hypercapnic acidosis in ARDS and sepsis. His current research focus is the investigation of the therapeutic potential of cell therapies for ARDS.

Recent Publications

  1. Dunbar, H, Weiss, DJ, Rolandsson Enes, S, Laffey, JG, English, K. The Inflammatory Lung Microenvironment; a Key Mediator in MSC Licensing. Cells. 2021;10 (11):. doi: 10.3390/cells10112982. PubMed PMID:34831203 .
  2. Russotto, V, Rahmani, LS, Parotto, M, Bellani, G, Laffey, JG. Tracheal intubation in the critically ill patient. Eur J Anaesthesiol. 2021; :. doi: 10.1097/EJA.0000000000001627. PubMed PMID:34799497 .
  3. Li Bassi, G, Suen, JY, White, N, Dalton, HJ, Fanning, J, Corley, A et al.. Assessment of 28-Day In-Hospital Mortality in Mechanically Ventilated Patients With Coronavirus Disease 2019: An International Cohort Study. Crit Care Explor. 2021;3 (11):e0567. doi: 10.1097/CCE.0000000000000567. PubMed PMID:34765979 PubMed Central PMC8575423.
  4. Gorman, E, Shankar-Hari, M, Hopkins, P, Tunnicliffe, WS, Perkins, GD, Silversides, J et al.. Repair of acute respiratory distress syndrome by stromal cell administration (REALIST) trial: A phase 1 trial. EClinicalMedicine. 2021;41 :101167. doi: 10.1016/j.eclinm.2021.101167. PubMed PMID:34746723 PubMed Central PMC8551601.
  5. Masterson, C, Gonzalez, H, Laffey, JG. Understanding the impact of the lung microenvironment to enhance the therapeutic potential of mesenchymal stromal cells for acute respiratory distress syndrome. Eur Respir J. 2021;58 (4):. doi: 10.1183/13993003.00986-2021. PubMed PMID:34649970 .
  6. Writing Committee for the REMAP-CAP Investigators, Estcourt, LJ, Turgeon, AF, McQuilten, ZK, McVerry, BJ, Al-Beidh, F et al.. Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial. JAMA. 2021;326 (17):1690-1702. doi: 10.1001/jama.2021.18178. PubMed PMID:34606578 PubMed Central PMC8491132.
  7. Wildi, K, Li Bassi, G, Barnett, A, Panigada, M, Colombo, SM, Bandera, A et al.. Design and Rationale of a Prospective International Follow-Up Study on Intensive Care Survivors of COVID-19: The Long-Term Impact in Intensive Care Survivors of Coronavirus Disease-19-AFTERCOR. Front Med (Lausanne). 2021;8 :738086. doi: 10.3389/fmed.2021.738086. PubMed PMID:34568393 PubMed Central PMC8455846.
  8. Ehrmann, S, Li, J, Ibarra-Estrada, M, Perez, Y, Pavlov, I, McNicholas, B et al.. Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomised, controlled, multinational, open-label meta-trial. Lancet Respir Med. 2021; :. doi: 10.1016/S2213-2600(21)00356-8. PubMed PMID:34425070 PubMed Central PMC8378833.
  9. Robba, C, Citerio, G, Taccone, FS, Galimberti, S, Rebora, P, Vargiolu, A et al.. Multicentre observational study on practice of ventilation in brain injured patients: the VENTIBRAIN study protocol. BMJ Open. 2021;11 (8):e047100. doi: 10.1136/bmjopen-2020-047100. PubMed PMID:34380722 PubMed Central PMC8359464.
  10. Masterson, CH, O'Toole, D, Laffey, JG. Inhaled CO2 to Reduce Lung Ischemia and Reperfusion Injuries: Moving toward Clinical Translation?. Am J Respir Crit Care Med. 2021;204 (8):878-879. doi: 10.1164/rccm.202107-1665ED. PubMed PMID:34375575 PubMed Central PMC8534625.
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Chief, Department of Anesthesia, St. Michael’s Hospital
  • Professor, Anesthesia, Critical Care, and Physiology, University of Toronto