John Laffey


Affiliate Scientist


Dr. Laffey is Anesthesiologist-in-Chief at St Michael’s Hospital, Toronto, Co-Director of the Critical Illness and Injury Research Centre at the Keenan Research Centre, St. Michael’s hospital. He is a Clinician Scientist at the Keenan Research Centre, and Professor of Anesthesia, Critical Care and Physiology at the University of Toronto. His research is focused on ARDS, particularly the mechanisms underlying ventilation induced lung injury. He has a longstanding interest in the effects and mechanisms of hypercapnic acidosis in ARDS and sepsis. His current research focus is the investigation of the therapeutic potential of cell therapies for ARDS.

Recent Publications

  1. Rezoagli, E, McNicholas, BA, Madotto, F, Pham, T, Bellani, G, Laffey, JG et al.. Presence of comorbidities alters management and worsens outcome of patients with acute respiratory distress syndrome: insights from the LUNG SAFE study. Ann Intensive Care. 2022;12 (1):42. doi: 10.1186/s13613-022-01015-7. PubMed PMID:35596885 PubMed Central PMC9123875.
  2. Li Bassi, G, Gibbons, K, Suen, JY, Dalton, HJ, White, N, Corley, A et al.. Early short course of neuromuscular blocking agents in patients with COVID-19 ARDS: a propensity score analysis. Crit Care. 2022;26 (1):141. doi: 10.1186/s13054-022-03983-5. PubMed PMID:35581612 PubMed Central PMC9112652.
  3. Gorman, E, Shankar-Hari, M, Hopkins, P, Tunnicliffe, WS, Perkins, GD, Silversides, J et al.. Repair of acute respiratory distress syndrome by stromal cell administration (REALIST): a structured study protocol for an open-label dose-escalation phase 1 trial followed by a randomised, triple-blind, allocation concealed, placebo-controlled phase 2 trial. Trials. 2022;23 (1):401. doi: 10.1186/s13063-022-06220-0. PubMed PMID:35562778 PubMed Central PMC9099345.
  4. Russotto, V, Tassistro, E, Myatra, SN, Parotto, M, Antolini, L, Bauer, P et al.. Peri-intubation Cardiovascular Collapse in Critically Ill Patients: Insights from the INTUBE Study. Am J Respir Crit Care Med. 2022; :. doi: 10.1164/rccm.202111-2575OC. PubMed PMID:35536310 .
  5. Urner, M, Barnett, AG, Bassi, GL, Brodie, D, Dalton, HJ, Ferguson, ND et al.. Venovenous extracorporeal membrane oxygenation in patients with acute covid-19 associated respiratory failure: comparative effectiveness study. BMJ. 2022;377 :e068723. doi: 10.1136/bmj-2021-068723. PubMed PMID:35508314 PubMed Central PMC9065544.
  6. Mistry, S, Das, A, Saffaran, S, Yehya, N, Scott, TE, Chikhani, M et al.. Validation of at-the-bedside formulae for estimating ventilator driving pressure during airway pressure release ventilation using computer simulation. Respir Res. 2022;23 (1):101. doi: 10.1186/s12931-022-01985-z. PubMed PMID:35473715 PubMed Central PMC9039982.
  7. Hannon, DM, Mistry, S, Das, A, Saffaran, S, Laffey, JG, Brook, BS et al.. Modeling Mechanical Ventilation In Silico-Potential and Pitfalls. Semin Respir Crit Care Med. 2022; :. doi: 10.1055/s-0042-1744446. PubMed PMID:35451046 .
  8. Weaver, L, Das, A, Saffaran, S, Yehya, N, Chikhani, M, Scott, TE et al.. Optimising respiratory support for early COVID-19 pneumonia: a computational modelling study. Br J Anaesth. 2022;128 (6):1052-1058. doi: 10.1016/j.bja.2022.02.037. PubMed PMID:35410790 PubMed Central PMC8930396.
  9. Laake, JH, Småstuen, MC, Møller, MH, Larsson, A, Aslam, TN, Hofsø, K et al.. Patient characteristics, management and outcomes in a Nordic subset of the "large observational study to understand the global impact of severe acute respiratory failure" (LUNG SAFE) study. Acta Anaesthesiol Scand. 2022; :. doi: 10.1111/aas.14069. PubMed PMID:35398892 .
  10. Ibarra-Estrada, M, Li, J, Pavlov, I, Perez, Y, Roca, O, Tavernier, E et al.. Factors for success of awake prone positioning in patients with COVID-19-induced acute hypoxemic respiratory failure: analysis of a randomized controlled trial. Crit Care. 2022;26 (1):84. doi: 10.1186/s13054-022-03950-0. PubMed PMID:35346319 PubMed Central PMC8958810.
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science, St. Michael’s Hospital
  • Chief, Department of Anesthesia, St. Michael’s Hospital
  • Professor, Anesthesia, Critical Care, and Physiology, University of Toronto