John Marshall




Dr. John Marshall is a Professor of Surgery at the University of Toronto, and a Trauma Surgeon and Intensivist at St. Michael’s Hospital in Toronto, Canada.  His academic interests are sepsis, trauma, and the innate immune response.  His laboratory studies the cellular mechanisms that prolong neutrophil survival in critical illness by preventing neutrophil programmed cell death, or apoptosis.  Professor Marshall has an active clinical research interest in sepsis and Intensive Care Unit-acquired infection, and in the design of clinical trials and outcome measures.  He has published 315 manuscripts, and 80 book chapters, and is the editor of 2 books.  He is the founding chair of the International Forum of Acute Care Trialists (InFACT) – a global network of investigator-led critical care clinical research groups, Secretary-General of the World Federation of Societies of Intensive and Critical Care Medicine, and vice-chair of the International Severe Acute Respiratory Infections Consortium.  He is past-chair of the International Sepsis Forum, past-President of the Surgical Infection Society, and past-chair of the Canadian Critical Care Trials Group.  He has given invited lectures at more than 460 meetings around the world, and is a member of the editorial boards of seven journals.

Recent Publications

  1. Hughes, A, Marshall, JK, Moretti, ME, Ungar, WJ. A Cost-Utility Analysis of Switching from Reference to Biosimilar Infliximab Compared to Maintaining Reference Infliximab in Adult Patients with Crohn's Disease. J Can Assoc Gastroenterol. 2021;4 (1):48. doi: 10.1093/jcag/gwz045. PubMed PMID:33644677 PubMed Central PMC7898373.
  2. REMAP-CAP Investigators, Gordon, AC, Mouncey, PR, Al-Beidh, F, Rowan, KM, Nichol, AD et al.. Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19. N Engl J Med. 2021; :. doi: 10.1056/NEJMoa2100433. PubMed PMID:33631065 .
  3. Benchimol, EI, Tse, F, Carroll, MW, deBruyn, JC, McNeil, SA, Pham-Huy, A et al.. TEMPORARY REMOVAL: Canadian Association of Gastroenterology CLINICAL Practice Guideline For Immunizations in Patients with Inflammatory Bowel Disease (IBD). Part 2: Inactivated Vaccines. Gastroenterology. 2021; :. doi: 10.1053/j.gastro.2020.12.079. PubMed PMID:33617891 .
  4. Aryal, D, Beane, A, Dondorp, AM, Green, C, Haniffa, R, Hashmi, M et al.. Operationalisation of the Randomized Embedded Multifactorial Adaptive Platform for COVID-19 trials in a low and lower-middle income critical care learning health system. Wellcome Open Res. 2021;6 :14. doi: 10.12688/wellcomeopenres.16486.1. PubMed PMID:33604455 PubMed Central PMC7883321.
  5. Leeies, M, Gershengorn, HB, Charbonney, E, Kumar, A, Fergusson, D, Turgeon, AF et al.. Intravenous immune globulin in septic shock: a Canadian national survey of critical care medicine and infectious disease specialist physicians. Can J Anaesth. 2021; :. doi: 10.1007/s12630-021-01941-3. PubMed PMID:33598888 .
  6. DeMerle, KM, Angus, DC, Baillie, JK, Brant, E, Calfee, CS, Carcillo, J et al.. Sepsis Subclasses: A Framework for Development and Interpretation. Crit Care Med. 2021; :. doi: 10.1097/CCM.0000000000004842. PubMed PMID:33591001 .
  7. Piva, S, DiBlasi, RM, Slee, AE, Jobe, AH, Roccaro, AM, Filippini, M et al.. Surfactant therapy for COVID-19 related ARDS: a retrospective case-control pilot study. Respir Res. 2021;22 (1):20. doi: 10.1186/s12931-020-01603-w. PubMed PMID:33461535 PubMed Central PMC7812332.
  8. Zhen, J, Marshall, JK, Nguyen, GC, Atreja, A, Narula, N. Impact of Digital Health Monitoring in the Management of Inflammatory Bowel Disease. J Med Syst. 2021;45 (2):23. doi: 10.1007/s10916-021-01706-x. PubMed PMID:33449213 PubMed Central PMC7808932.
  9. Tong, A, Baumgart, A, Evangelidis, N, Viecelli, AK, Carter, SA, Azevedo, LC et al.. Core Outcome Measures for Trials in People With Coronavirus Disease 2019: Respiratory Failure, Multiorgan Failure, Shortness of Breath, and Recovery. Crit Care Med. 2021;49 (3):503-516. doi: 10.1097/CCM.0000000000004817. PubMed PMID:33400475 PubMed Central PMC7892260.
  10. Ektesabi, AM, Mori, K, Tsoporis, J, Vaswani, C, Gupta, S, Walsh, C et al.. Mesenchymal Stem/Stromal Cells Increase Cardiac MIR-187-3P Expression in Polymicrobial Animal Model of Sepsis. Shock. 2020;Publish Ahead of Print :. doi: 10.1097/SHK.0000000000001701. PubMed PMID:33378320 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science
  • Trauma Surgeon and Intensivist, St. Michael’s Hospital
  • Professor, Department of Surgery, University of Toronto