John Marshall




Dr. John Marshall is a Professor of Surgery at the University of Toronto, and an Intensivist at St. Michael’s Hospital in Toronto, Canada.  His academic interests are sepsis, trauma, and the innate immune response.  His laboratory studies the cellular mechanisms that prolong neutrophil survival in critical illness by preventing neutrophil programmed cell death, or apoptosis.  Professor Marshall has an active clinical research interest in sepsis and Intensive Care Unit-acquired infection, and in the design of clinical trials and outcome measures.  He has published 440 manuscripts, and 85 book chapters, and is the editor of 2 books.  He is the founding chair of the International Forum of Acute Care Trialists (InFACT) – a global network of investigator-led critical care clinical research groups, and past Secretary-General of the World Federation of Societies of Intensive and Critical Care Medicine.  He co-chairs the WHO R&D Working Group on the Clinical Characterization and Management of COVID-19.  He is past-chair of the International Sepsis Forum, past-President of the Surgical Infection Society, and past-chair of the Canadian Critical Care Trials Group.  He has given invited lectures at more than 540 meetings around the world, and is an Associate Editor of the journals Critical Care Medicine and Critical care.”

Recent Publications

  1. Quan, J, Ma, C, Panaccione, R, Hracs, L, Sharifi, N, Herauf, M et al.. Serological responses to three doses of SARS-CoV-2 vaccination in inflammatory bowel disease. Gut. 2022; :. doi: 10.1136/gutjnl-2022-327440. PubMed PMID:35606090 .
  2. Toma, A, Dos Santos, C, Burzyńska, B, Góra, M, Kiliszek, M, Stickle, N et al.. Diversity in the Expressed Genomic Host Response to Myocardial Infarction. Circ Res. 2022; :101161CIRCRESAHA121318391. doi: 10.1161/CIRCRESAHA.121.318391. PubMed PMID:35534922 .
  3. Fenu, E, Lukyanov, V, Acs, A, Radu, X, Stypa, S, Fischer, A et al.. Cost Effectiveness of Subcutaneous Vedolizumab for Maintenance Treatment of Ulcerative Colitis in Canada. Pharmacoecon Open. 2022; :. doi: 10.1007/s41669-022-00331-9. PubMed PMID:35474178 .
  4. Soussi, S, Sharma, D, Jüni, P, Lebovic, G, Brochard, L, Marshall, JC et al.. Identifying clinical subtypes in sepsis-survivors with different one-year outcomes: a secondary latent class analysis of the FROG-ICU cohort. Crit Care. 2022;26 (1):114. doi: 10.1186/s13054-022-03972-8. PubMed PMID:35449071 PubMed Central PMC9022336.
  5. Lee, T, Cheng, MP, Vinh, DC, Lee, TC, Tran, KC, Winston, BW et al.. Organ dysfunction and death in patients admitted to hospital with COVID-19 in pandemic waves 1 to 3 in British Columbia, Ontario and Quebec, Canada: a cohort study. CMAJ Open. ;10 (2):E379-E389. doi: 10.9778/cmajo.20210216. PubMed PMID:35440485 PubMed Central PMC9022939.
  6. REMAP-CAP Writing Committee for the REMAP-CAP Investigators, Bradbury, CA, Lawler, PR, Stanworth, SJ, McVerry, BJ, McQuilten, Z et al.. Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial. JAMA. 2022;327 (13):1247-1259. doi: 10.1001/jama.2022.2910. PubMed PMID:35315874 PubMed Central PMC8941448.
  7. Rüddel, H, Thomas-Rüddel, DO, Reinhart, K, Bach, F, Gerlach, H, Lindner, M et al.. Adverse effects of delayed antimicrobial treatment and surgical source control in adults with sepsis: results of a planned secondary analysis of a cluster-randomized controlled trial. Crit Care. 2022;26 (1):51. doi: 10.1186/s13054-022-03901-9. PubMed PMID:35227308 PubMed Central PMC8883454.
  8. Marshall, JC, Deutschman, CS. The authors reply. Crit Care Med. 2022;50 (3):e337-e338. doi: 10.1097/CCM.0000000000005413. PubMed PMID:35191892 .
  9. Mohammed, Y, Goodlett, DR, Cheng, MP, Vinh, DC, Lee, TC, Mcgeer, A et al.. Longitudinal Plasma Proteomics Analysis Reveals Novel Candidate Biomarkers in Acute COVID-19. J Proteome Res. 2022;21 (4):975-992. doi: 10.1021/acs.jproteome.1c00863. PubMed PMID:35143212 PubMed Central PMC8864781.
  10. Rehm, HL, Page, AJH, Smith, L, Adams, JB, Alterovitz, G, Babb, LJ et al.. GA4GH: International policies and standards for data sharing across genomic research and healthcare. Cell Genom. 2021;1 (2):. doi: 10.1016/j.xgen.2021.100029. PubMed PMID:35072136 PubMed Central PMC8774288.
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science
  • Trauma Surgeon and Intensivist, St. Michael’s Hospital
  • Professor, Department of Surgery, University of Toronto