John Marshall




Dr. John Marshall is a Professor of Surgery at the University of Toronto, and an Intensivist at St. Michael’s Hospital in Toronto, Canada.  His academic interests are sepsis, trauma, and the innate immune response.  His laboratory studies the cellular mechanisms that prolong neutrophil survival in critical illness by preventing neutrophil programmed cell death, or apoptosis.  Professor Marshall has an active clinical research interest in sepsis and Intensive Care Unit-acquired infection, and in the design of clinical trials and outcome measures.  He has published 440 manuscripts, and 85 book chapters, and is the editor of 2 books.  He is the founding chair of the International Forum of Acute Care Trialists (InFACT) – a global network of investigator-led critical care clinical research groups, and past Secretary-General of the World Federation of Societies of Intensive and Critical Care Medicine.  He co-chairs the WHO R&D Working Group on the Clinical Characterization and Management of COVID-19.  He is past-chair of the International Sepsis Forum, past-President of the Surgical Infection Society, and past-chair of the Canadian Critical Care Trials Group.  He has given invited lectures at more than 540 meetings around the world, and is an Associate Editor of the journals Critical Care Medicine and Critical care.”

Recent Publications

  1. Writing Committee for the REMAP-CAP Investigators, Estcourt, LJ, Turgeon, AF, McQuilten, ZK, McVerry, BJ, Al-Beidh, F et al.. Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial. JAMA. 2021; :. doi: 10.1001/jama.2021.18178. PubMed PMID:34606578 PubMed Central PMC8491132.
  2. Latronico, N, Peli, E, Calza, S, Rodella, F, Novelli, MP, Cella, A et al.. Physical, cognitive and mental health outcomes in 1-year survivors of COVID-19-associated ARDS. Thorax. 2021; :. doi: 10.1136/thoraxjnl-2021-218064. PubMed PMID:34588274 .
  3. Schell, CO, Khalid, K, Wharton-Smith, A, Oliwa, J, Sawe, HR, Roy, N et al.. Essential Emergency and Critical Care: a consensus among global clinical experts. BMJ Glob Health. 2021;6 (9):. doi: 10.1136/bmjgh-2021-006585. PubMed PMID:34548380 PubMed Central PMC8458367.
  4. Johnstone, J, Meade, M, Lauzier, F, Marshall, J, Duan, E, Dionne, J et al.. Effect of Probiotics on Incident Ventilator-Associated Pneumonia in Critically Ill Patients: A Randomized Clinical Trial. JAMA. 2021;326 (11):1024-1033. doi: 10.1001/jama.2021.13355. PubMed PMID:34546300 PubMed Central PMC8456390.
  5. Jones, JL, Tse, F, Carroll, MW, deBruyn, JC, McNeil, SA, Pham-Huy, A et al.. Canadian Association of Gastroenterology Clinical Practice Guideline for Immunizations in Patients With Inflammatory Bowel Disease (IBD)-Part 2: Inactivated Vaccines. J Can Assoc Gastroenterol. 2021;4 (4):e72-e91. doi: 10.1093/jcag/gwab016. PubMed PMID:34476339 PubMed Central PMC8407486.
  6. Benchimol, EI, Tse, F, Carroll, MW, deBruyn, JC, McNeil, SA, Pham-Huy, A et al.. Canadian Association of Gastroenterology Clinical Practice Guideline for Immunizations in Patients With Inflammatory Bowel Disease (IBD)-Part 1: Live Vaccines. J Can Assoc Gastroenterol. 2021;4 (4):e59-e71. doi: 10.1093/jcag/gwab015. PubMed PMID:34476338 PubMed Central PMC8407487.
  7. Wang, JF, Wang, YP, Xie, J, Zhao, ZZ, Gupta, S, Guo, Y et al.. Upregulated PD-L1 delays human neutrophil apoptosis and promotes lung injury in an experimental mouse model of sepsis. Blood. 2021;138 (9):806-810. doi: 10.1182/blood.2020009417. PubMed PMID:34473230 .
  8. Wong, ECL, Colombel, JF, Riddell, R, Marshall, JK, Reinisch, W, Dulai, PS et al.. Epithelial Neutrophilic Infiltrate: The Rising Star in Ulcerative Colitis. Clin Gastroenterol Hepatol. 2021; :. doi: 10.1016/j.cgh.2021.08.024. PubMed PMID:34425279 .
  9. Bonert, M, Naqvi, A, Rahman, M, Marshall, JK, Xenodemetropoulos, T, Arora, P et al.. Stability of diagnostic rate in a cohort of 38,813 colorectal polyp specimens and implications for histomorphology and statistical process control. Sci Rep. 2021;11 (1):16942. doi: 10.1038/s41598-021-95862-2. PubMed PMID:34417490 PubMed Central PMC8379162.
  10. Kosyakovsky, LB, Angriman, F, Katz, E, Adhikari, NK, Godoy, LC, Marshall, JC et al.. Association between sepsis survivorship and long-term cardiovascular outcomes in adults: a systematic review and meta-analysis. Intensive Care Med. 2021;47 (9):931-942. doi: 10.1007/s00134-021-06479-y. PubMed PMID:34373953 .
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Affiliations & Other Activities

  • Scientist, Keenan Research Centre for Biomedical Science
  • Trauma Surgeon and Intensivist, St. Michael’s Hospital
  • Professor, Department of Surgery, University of Toronto