Karim Ladha




Dr. Karim Ladha is a clinician-scientist and staff anesthesiologist at St. Michael’s Hospital and the University of Toronto. Dr. Ladha received his medical degree from the Johns Hopkins University School of Medicine. He then completed his anesthesia training at Massachusetts General Hospital and obtained a fellowship in cardiac anesthesia at Toronto General Hospital. He also holds a Master’s degree in clinical epidemiology from the Harvard School of Public Health. His program of research uses mixed methodologies to obtain a multifaceted view of pain and recovery after surgery including retrospective analyses of administrative databases, prospective observational studies, and multi-center randomized controlled trials. His research has been published in top-tier journals including JAMA, BMJ, British Journal of Anesthesia and Anesthesiology. He has received numerous awards for his work including the International Anesthesia Research Society Mentored Research Award, a new investigator award from the Canadian Anesthesiologists’ Society and the IMPACT award in anesthesia.

Please note: Dr. Ladha is not accepting any students at this time.

Recent Publications

  1. Meng, H, Page, MG, Ajrawat, P, Deshpande, A, Samman, B, Dominicis, M et al.. Patient-reported outcomes in those consuming medical cannabis: a prospective longitudinal observational study in chronic pain patients. Can J Anaesth. 2021; :. doi: 10.1007/s12630-020-01903-1. PubMed PMID:33469735 .
  2. Ramos, RJ, Ladha, KS, Cuthbertson, BH, Shulman, MA, Myles, PS, Wijeysundera, DN et al.. Association of six-minute walk test distance with postoperative complications in non-cardiac surgery: a secondary analysis of a multicentre prospective cohort study. Can J Anaesth. 2021; :. doi: 10.1007/s12630-020-01909-9. PubMed PMID:33442834 .
  3. Ladha, KS, McLaren-Blades, A, Goel, A, Buys, MJ, Farquhar-Smith, P, Haroutounian, S et al.. Perioperative Pain and Addiction Interdisciplinary Network (PAIN): consensus recommendations for perioperative management of cannabis and cannabinoid-based medicine users by a modified Delphi process. Br J Anaesth. 2021;126 (1):304-318. doi: 10.1016/j.bja.2020.09.026. PubMed PMID:33129489 .
  4. Shanthanna, H, Ladha, KS, Kehlet, H, Joshi, GP. Perioperative Opioid Administration: A Critical Review of Opioid-free versus Opioid-sparing Approaches. Anesthesiology. 2020; :. doi: 10.1097/ALN.0000000000003572. PubMed PMID:32991672 .
  5. Ladha, KS, Ajrawat, P, Yang, Y, Clarke, H. Understanding the Medical Chemistry of the Cannabis Plant is Critical to Guiding Real World Clinical Evidence. Molecules. 2020;25 (18):. doi: 10.3390/molecules25184042. PubMed PMID:32899678 PubMed Central PMC7570835.
  6. McGuinness, B, Goel, A, Elias, F, Rapanos, T, Mittleman, MA, Ladha, KS et al.. Cannabis use disorder and perioperative outcomes in vascular surgery. J Vasc Surg. 2020; :. doi: 10.1016/j.jvs.2020.07.094. PubMed PMID:32861869 .
  7. McLaren-Blades, A, Ladha, K, Goel, A, Manoo, V, Kotteeswaran, Y, Gee, YY et al.. Perioperative pain and addiction interdisciplinary network (PAIN): protocol for the perioperative management of cannabis and cannabinoid-based medicines using a modified Delphi process. BMJ Open. 2020;10 (7):e036472. doi: 10.1136/bmjopen-2019-036472. PubMed PMID:32690522 PubMed Central PMC7371125.
  8. Bethell, J, Neuman, MD, Bateman, BT, Ladha, KS, Hill, A, Li, G et al.. Association between mothers' postoperative opioid prescriptions and opioid-related events in their children: A population-based cohort study. Health Rep. 2020;31 (6):12-19. doi: 10.25318/82-003-x202000600002-eng. PubMed PMID:32672924 .
  9. Diep, C, Wong, D, Wijeysundera, DN, Katz, J, Clarke, HA, Ladha, KS et al.. The association between patient-reported pain scores and physical activity in the postoperative period: A prospective observational study. J Clin Anesth. 2020;66 :109916. doi: 10.1016/j.jclinane.2020.109916. PubMed PMID:32485540 .
  10. Clarke, H, Roychoudhury, P, Ladha, KS, Leroux, T, Fiorellino, J, Huang, A et al.. Daring discourse - yes: practical considerations for cannabis use in the perioperative setting. Reg Anesth Pain Med. 2020;45 (7):524-527. doi: 10.1136/rapm-2020-101521. PubMed PMID:32471923 .
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Affiliations & Other Activities

Department of Anesthesia and Pain Management – University of Toronto and St. Michael’s Hospital