Karim Ladha


Scientist, Li Ka Shing Knowledge Institute


Dr. Karim Ladha is a clinician-scientist and staff anesthesiologist at St. Michael’s Hospital and the University of Toronto. Dr. Ladha received his medical degree from the Johns Hopkins University School of Medicine. He then completed his anesthesia training at Massachusetts General Hospital and obtained a fellowship in cardiac anesthesia at Toronto General Hospital. He also holds a Master’s degree in clinical epidemiology from the Harvard School of Public Health. His program of research uses mixed methodologies to obtain a multifaceted view of pain and recovery after surgery including retrospective analyses of administrative databases, prospective observational studies, and multi-center randomized controlled trials. His research has been published in top-tier journals including JAMA, BMJ, British Journal of Anesthesia and Anesthesiology. He has received numerous awards for his work including the International Anesthesia Research Society Mentored Research Award, a new investigator award from the Canadian Anesthesiologists’ Society and the IMPACT award in anesthesia.

His current research interests include:

–       Exploring the use of anesthetic drugs such as ketamine and nitrous oxide to treat depression

–       Understanding the role of cannabis in mitigating pain

–       Using wearable technology and mobile applications to track recovery after surgery

Please note: Dr. Ladha is not accepting any students at this time.

Recent Publications

  1. Pagé, MG, Ladha, KS. Moving Beyond a Single Score: The Upward Trajectory of Perioperative Pain Assessment. Anesth Analg. 2022;134 (2):276-278. doi: 10.1213/ANE.0000000000005759. PubMed PMID:35030123 .
  2. Vaccarino, SR, Adamsahib, F, Milev, RV, Parikh, SV, Lam, RW, Blier, P et al.. The Effects of Ketamine on Cognition in Unipolar and Bipolar Depression: A Systematic Review. J Clin Psychiatry. 2022;83 (1):. doi: 10.4088/JCP.21r13870. PubMed PMID:34985832 .
  3. Kerzner, J, Liu, H, Demchenko, I, Sussman, D, Wijeysundera, DN, Kennedy, SH et al.. Stellate Ganglion Block for Psychiatric Disorders: A Systematic Review of the Clinical Research Landscape. Chronic Stress (Thousand Oaks). ;5 :24705470211055176. doi: 10.1177/24705470211055176. PubMed PMID:34901677 PubMed Central PMC8664306.
  4. Chan, B, Ward, S, Abdallah, FW, Jones, C, Papachristos, A, Chin, K et al.. Opioid prescribing and utilization patterns in patients having elective hip and knee arthroplasty: association between prescription patterns and opioid consumption. Can J Anaesth. 2021; :. doi: 10.1007/s12630-021-02145-5. PubMed PMID:34873641 .
  5. Diep, C, Tian, C, Vachhani, K, Won, C, Wijeysundera, DN, Clarke, H et al.. Recent cannabis use and nightly sleep duration in adults: a population analysis of the NHANES from 2005 to 2018. Reg Anesth Pain Med. 2022;47 (2):100-104. doi: 10.1136/rapm-2021-103161. PubMed PMID:34873024 .
  6. Hanley, C, Ladha, KS, Clarke, HA, Cuthbertson, BC, Wijeysundera, DN, METS Study Investigators et al.. Association of postoperative complications with persistent post-surgical pain: a multicentre prospective cohort study. Br J Anaesth. 2022;128 (2):311-320. doi: 10.1016/j.bja.2021.10.027. PubMed PMID:34872718 .
  7. Muaddi, H, Lillie, E, Silva, S, Cross, JL, Ladha, K, Choi, S et al.. The Effect of Cryotherapy Application on Post-operative Pain: A Systematic Review and Meta-analysis. Ann Surg. 2021; :. doi: 10.1097/SLA.0000000000004987. PubMed PMID:34856580 .
  8. Pope, MK, Hall, TS, Schirripa, V, Radic, P, Virdone, S, Pieper, KS et al.. Cardioversion in patients with newly diagnosed non-valvular atrial fibrillation: observational study using prospectively collected registry data. BMJ. 2021;375 :e066450. doi: 10.1136/bmj-2021-066450. PubMed PMID:34706884 PubMed Central PMC8548918.
  9. Demchenko, I, Blumberger, DM, Flint, AJ, Anderson, M, Daskalakis, ZJ, Foley, K et al.. Electroconvulsive Therapy in Canada During the First Wave of COVID-19: Results of the "What Happened" National Survey. J ECT. 2021; :. doi: 10.1097/YCT.0000000000000801. PubMed PMID:34519681 .
  10. Ladha, KS, Mistry, N, Wijeysundera, DN, Clarke, H, Verma, S, Hare, GMT et al.. Recent cannabis use and myocardial infarction in young adults: a cross-sectional study. CMAJ. 2021;193 (35):E1377-E1384. doi: 10.1503/cmaj.202392. PubMed PMID:34493564 PubMed Central PMC8443297.
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Affiliations & Other Activities

  • Department of Anesthesia and Pain Management – University of Toronto and St. Michael’s Hospital