Karim Ladha




Dr. Karim Ladha is a clinician-scientist and staff anesthesiologist at St. Michael’s Hospital and the University of Toronto. Dr. Ladha received his medical degree from the Johns Hopkins University School of Medicine. He then completed his anesthesia training at Massachusetts General Hospital and obtained a fellowship in cardiac anesthesia at Toronto General Hospital. He also holds a Master’s degree in clinical epidemiology from the Harvard School of Public Health. His program of research uses mixed methodologies to obtain a multifaceted view of pain and recovery after surgery including retrospective analyses of administrative databases, prospective observational studies, and multi-center randomized controlled trials. His research has been published in top-tier journals including JAMA, BMJ, British Journal of Anesthesia and Anesthesiology. He has received numerous awards for his work including the International Anesthesia Research Society Mentored Research Award, a new investigator award from the Canadian Anesthesiologists’ Society and the IMPACT award in anesthesia.

His current research interests include:

–       Exploring the use of anesthetic drugs such as ketamine and nitrous oxide to treat depression

–       Understanding the role of cannabis in mitigating pain

–       Using wearable technology and mobile applications to track recovery after surgery

Please note: Dr. Ladha is not accepting any students at this time.

Recent Publications

  1. Demchenko, I, Blumberger, DM, Flint, AJ, Anderson, M, Daskalakis, ZJ, Foley, K et al.. Electroconvulsive Therapy in Canada During the First Wave of COVID-19: Results of the "What Happened" National Survey. J ECT. 2021; :. doi: 10.1097/YCT.0000000000000801. PubMed PMID:34519681 .
  2. Ladha, KS, Mistry, N, Wijeysundera, DN, Clarke, H, Verma, S, Hare, GMT et al.. Recent cannabis use and myocardial infarction in young adults: a cross-sectional study. CMAJ. 2021;193 (35):E1377-E1384. doi: 10.1503/cmaj.202392. PubMed PMID:34493564 PubMed Central PMC8443297.
  3. Ladha, KS, Wijeysundera, DN, Wunsch, H, Clarke, H, Diep, C, Gomes, T et al.. The association between prescription opioid dispensing and opioid-related morbidity and mortality in Ontario, Canada: an ecological study of public health units. Drug Alcohol Depend. 2021;227 :108989. doi: 10.1016/j.drugalcdep.2021.108989. PubMed PMID:34482045 .
  4. Shanthanna, H, Ladha, KS, Kehlet, H, Joshi, GP. Opioid-free Anesthesia: Reply. Anesthesiology. 2021;135 (4):758-759. doi: 10.1097/ALN.0000000000003907. PubMed PMID:34388826 .
  5. COVIDSurg Collaborative, GlobalSurg Collaborative. Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study. Anaesthesia. 2021; :. doi: 10.1111/anae.15560. PubMed PMID:34371522 .
  6. Clarke, H, Meng, H, Ladha, KS, Kotra, LP. In reply: Comment on: Patient-reported outcomes in those consuming medical cannabis: a prospective longitudinal observational study in patients with chronic pain. Can J Anaesth. 2021; :. doi: 10.1007/s12630-021-02079-y. PubMed PMID:34350559 .
  7. Ladha, KS, McLaren-Blades, A, Clarke, H. Concerns about Recommendations for Perioperative Cannabis Use. JAMA Surg. 2021; :. doi: 10.1001/jamasurg.2021.2259. PubMed PMID:34132769 .
  8. Aternali, A, Slepian, PM, Clarke, H, Ladha, KS, Katznelson, R, McRae, K et al.. Presurgical distress about bodily sensations predicts chronic postsurgical pain intensity and disability 6 months after cardiothoracic surgery. Pain. 2021; :. doi: 10.1097/j.pain.0000000000002325. PubMed PMID:34086627 .
  9. Liu, CW, Page, MG, Weinrib, A, Wong, D, Huang, A, McRae, K et al.. Predictors of one year chronic post-surgical pain trajectories following thoracic surgery. J Anesth. 2021;35 (4):505-514. doi: 10.1007/s00540-021-02943-7. PubMed PMID:34002257 .
  10. Santa Mina, D, Sellers, D, Au, D, Alibhai, SMH, Clarke, H, Cuthbertson, BH et al.. A Pragmatic Non-Randomized Trial of Prehabilitation Prior to Cancer Surgery: Study Protocol and COVID-19-Related Adaptations. Front Oncol. 2021;11 :629207. doi: 10.3389/fonc.2021.629207. PubMed PMID:33777780 PubMed Central PMC7987917.
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Affiliations & Other Activities

Department of Anesthesia and Pain Management – University of Toronto and St. Michael’s Hospital