Laurent J. Brochard


Scientist, Keenan Research Centre for Biomedical Science


Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Yehya, N, Hodgson, CL, Amato, MBP, Richard, JC, Brochard, LJ, Mercat, A et al.. Response to Ventilator Adjustments for Predicting ARDS Mortality: Driving Pressure versus Oxygenation. Ann Am Thorac Soc. 2020; :. doi: 10.1513/AnnalsATS.202007-862OC. PubMed PMID:33112644 .
  2. Bastia, L, Engelberts, D, Osada, K, Katira, BH, Damiani, LF, Yoshida, T et al.. Role of PEEP and Regional Transpulmonary Pressure in Asymmetrical Lung Injury. Am J Respir Crit Care Med. 2020; :. doi: 10.1164/rccm.202005-1556OC. PubMed PMID:33091317 .
  3. Daou, M, Telias, I, Younes, M, Brochard, L, Wilcox, ME. Abnormal Sleep, Circadian Rhythm Disruption, and Delirium in the ICU: Are They Related?. Front Neurol. 2020;11 :549908. doi: 10.3389/fneur.2020.549908. PubMed PMID:33071941 PubMed Central PMC7530631.
  4. Rozé, H, Boisselier, C, Bonnardel, E, Perrier, V, Repusseau, B, Brochard, L et al.. Electrical Impedance Tomography to Detect Airway Closure Heterogeneity in Asymmetrical ARDS. Am J Respir Crit Care Med. 2020; :. doi: 10.1164/rccm.202007-2937LE. PubMed PMID:33030960 .
  5. Fernando, SM, Fan, E, Rochwerg, B, Burns, KEA, Brochard, LJ, Cook, DJ et al.. Lung-Protective Ventilation and Associated Outcomes and Costs Among Patients Receiving Invasive Mechanical Ventilation in the Emergency Department. Chest. 2020; :. doi: 10.1016/j.chest.2020.09.100. PubMed PMID:32966812 .
  6. Granton, D, Chaudhuri, D, Wang, D, Einav, S, Helviz, Y, Mauri, T et al.. High-Flow Nasal Cannula Compared With Conventional Oxygen Therapy or Noninvasive Ventilation Immediately Postextubation: A Systematic Review and Meta-Analysis. Crit Care Med. 2020;48 (11):e1129-e1136. doi: 10.1097/CCM.0000000000004576. PubMed PMID:32947472 .
  7. Grieco, DL, Bongiovanni, F, Chen, L, Menga, LS, Cutuli, SL, Pintaudi, G et al.. Respiratory physiology of COVID-19-induced respiratory failure compared to ARDS of other etiologies. Crit Care. 2020;24 (1):529. doi: 10.1186/s13054-020-03253-2. PubMed PMID:32859264 PubMed Central PMC7453378.
  8. Dianti, J, Matelski, J, Tisminetzky, M, Walkey, AJ, Munshi, L, Del Sorbo, L et al.. Comparing the Effects of Tidal Volume, Driving Pressure, and Mechanical Power on Mortality in Trials of Lung-Protective Mechanical Ventilation. Respir Care. 2020; :. doi: 10.4187/respcare.07876. PubMed PMID:32843513 .
  9. Jonkman, AH, Katira, BH, Schreiber, A, Lu, C, Engelberts, D, Vieira, F et al.. A GAS-POWERED, PATIENT-RESPONSIVE AUTOMATIC RESUSCITATOR FOR USE IN ACUTE RESPIRATORY FAILURE: A BENCH AND EXPERIMENTAL STUDY. Respir Care. 2020; :. doi: 10.4187/respcare.08296. PubMed PMID:32817445 .
  10. Rodriguez, PO, Tiribelli, N, Fredes, S, Gogniat, E, Plotnikow, G, Ceballos, IF et al.. Prevalence of Reverse Triggering in Early ARDS: Results from a Multicenter Observational Study. Chest. 2020; :. doi: 10.1016/j.chest.2020.08.018. PubMed PMID:32805238 .
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Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group