Laurent J. Brochard




Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Goligher, EC, Costa, ELV, Yarnell, CJ, Brochard, LJ, Stewart, TE, Tomlinson, G et al.. Effect of Lowering Tidal Volume on Mortality in ARDS Varies with Respiratory System Elastance. Am J Respir Crit Care Med. 2021; :. doi: 10.1164/rccm.202009-3536OC. PubMed PMID:33439781 .
  2. Sklar, MC, Madotto, F, Jonkman, A, Rauseo, M, Soliman, I, Damiani, LF et al.. Duration of diaphragmatic inactivity after endotracheal intubation of critically ill patients. Crit Care. 2021;25 (1):26. doi: 10.1186/s13054-020-03435-y. PubMed PMID:33430930 PubMed Central PMC7798017.
  3. Katira, BH, Osada, K, Engelberts, D, Bastia, L, Damiani, LF, Li, X et al.. Positive End-Expiratory Pressure, Pleural Pressure, and Regional Compliance During Pronation: An Experimental Study. Am J Respir Crit Care Med. 2021; :. doi: 10.1164/rccm.202007-2957OC. PubMed PMID:33406012 .
  4. Pham, T, Pesenti, A, Bellani, G, Rubenfeld, G, Fan, E, Bugedo, G et al.. Outcome of Acute Hypoxaemic Respiratory Failure. Insights from the Lung Safe Study. Eur Respir J. 2020; :. doi: 10.1183/13993003.03317-2020. PubMed PMID:33334944 .
  5. Savary, D, Lesimple, A, Beloncle, F, Morin, F, Templier, F, Broc, A et al.. Reliability and limits of transport-ventilators to safely ventilate severe patients in special surge situations. Ann Intensive Care. 2020;10 (1):166. doi: 10.1186/s13613-020-00782-5. PubMed PMID:33296045 PubMed Central PMC7724620.
  6. Urner, M, Mitsakakis, N, Vorona, S, Chen, L, Sklar, MC, Dres, M et al.. Identifying Patients at Risk for Diaphragm Atrophy During Mechanical Ventilation Using Routinely Available Clinical Data. Respir Care. 2020; :. doi: 10.4187/respcare.08223. PubMed PMID:33293364 .
  7. Rochwerg, B, Einav, S, Chaudhuri, D, Mancebo, J, Mauri, T, Helviz, Y et al.. The role for high flow nasal cannula as a respiratory support strategy in adults: a clinical practice guideline. Intensive Care Med. 2020;46 (12):2226-2237. doi: 10.1007/s00134-020-06312-y. PubMed PMID:33201321 PubMed Central PMC7670292.
  8. Mauri, T, Foti, G, Fornari, C, Grasselli, G, Pinciroli, R, Lovisari, F et al.. Sigh in Patients With Acute Hypoxemic Respiratory Failure and ARDS: The PROTECTION Pilot Randomized Clinical Trial. Chest. 2020; :. doi: 10.1016/j.chest.2020.10.079. PubMed PMID:33197403 PubMed Central PMC7664474.
  9. Demoule, A, Brochard, L, Dres, M, Heunks, L, Jubran, A, Laghi, F et al.. How to ventilate obstructive and asthmatic patients. Intensive Care Med. 2020;46 (12):2436-2449. doi: 10.1007/s00134-020-06291-0. PubMed PMID:33169215 PubMed Central PMC7652057.
  10. Goligher, EC, Jonkman, AH, Dianti, J, Vaporidi, K, Beitler, JR, Patel, BK et al.. Clinical strategies for implementing lung and diaphragm-protective ventilation: avoiding insufficient and excessive effort. Intensive Care Med. 2020;46 (12):2314-2326. doi: 10.1007/s00134-020-06288-9. PubMed PMID:33140181 PubMed Central PMC7605467.
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Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group