Laurent J. Brochard

MD, HDR

Scientist

Biography

Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Ali, A, Wang, A, Ribeiro, RVP, Beroncal, EL, Baciu, C, Galasso, M et al.. Static lung storage at 10°C maintains mitochondrial health and preserves donor organ function. Sci Transl Med. 2021;13 (611):eabf7601. doi: 10.1126/scitranslmed.abf7601. PubMed PMID:34524862 .
  2. Sakr, Y, Midega, T, Antoniazzi, J, Solé-Violán, J, Bauer, PR, Ostermann, M et al.. Do ventilatory parameters influence outcome in patients with severe acute respiratory infection? Secondary analysis of an international, multicentre14-day inception cohort study. J Crit Care. 2021;66 :78-85. doi: 10.1016/j.jcrc.2021.08.008. PubMed PMID:34461380 PubMed Central PMC8394083.
  3. REMAP-CAP Investigators, ACTIV-4a Investigators, ATTACC Investigators, Goligher, EC, Bradbury, CA, McVerry, BJ et al.. Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19. N Engl J Med. 2021;385 (9):777-789. doi: 10.1056/NEJMoa2103417. PubMed PMID:34351722 PubMed Central PMC8362592.
  4. ATTACC Investigators, ACTIV-4a Investigators, REMAP-CAP Investigators, Lawler, PR, Goligher, EC, Berger, JS et al.. Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19. N Engl J Med. 2021;385 (9):790-802. doi: 10.1056/NEJMoa2105911. PubMed PMID:34351721 PubMed Central PMC8362594.
  5. Albaiceta, GM, Brochard, L, Dos Santos, CC, Fernández, R, Georgopoulos, D, Girard, T et al.. The central nervous system during lung injury and mechanical ventilation: a narrative review. Br J Anaesth. 2021; :. doi: 10.1016/j.bja.2021.05.038. PubMed PMID:34340836 .
  6. Beloncle, F, Studer, A, Seegers, V, Richard, JC, Desprez, C, Fage, N et al.. Longitudinal changes in compliance, oxygenation and ventilatory ratio in COVID-19 versus non-COVID-19 pulmonary acute respiratory distress syndrome. Crit Care. 2021;25 (1):248. doi: 10.1186/s13054-021-03665-8. PubMed PMID:34266454 PubMed Central PMC8280689.
  7. Arabi, YM, Gordon, AC, Derde, LPG, Nichol, AD, Murthy, S, Beidh, FA et al.. Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial. Intensive Care Med. 2021;47 (8):867-886. doi: 10.1007/s00134-021-06448-5. PubMed PMID:34251506 PubMed Central PMC8274471.
  8. Akoumianaki, E, Jonkman, A, Sklar, MC, Georgopoulos, D, Brochard, L. A rational approach on the use of extracorporeal membrane oxygenation in severe hypoxemia: advanced technology is not a panacea. Ann Intensive Care. 2021;11 (1):107. doi: 10.1186/s13613-021-00897-3. PubMed PMID:34250563 PubMed Central PMC8273031.
  9. Pinsky, MR, Brochard, LJ. CPAP to Counterbalance Elevated Pleural Pressure in Obese Patients: Restoring Functional Residual Capacity or Simply Keeping All Airways Open?. Chest. 2021;159 (6):2145-2146. doi: 10.1016/j.chest.2021.02.040. PubMed PMID:34099123 .
  10. Schreiber, AF, Bertoni, M, Coiffard, B, Fard, S, Wong, J, Reid, WD et al.. Abdominal Muscle Use During Spontaneous Breathing and Cough in Patients Who Are Mechanically Ventilated: A Bi-center Ultrasound Study. Chest. 2021; :. doi: 10.1016/j.chest.2021.05.053. PubMed PMID:34090872 .
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Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group
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