Laurent J. Brochard


Scientist, Keenan Research Centre for Biomedical Science


Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Mancebo, J, Mercat, A, Brochard, L. Maximal Lung Recruitment in ARDS: A Nail in the Coffin. Am. J. Respir. Crit. Care Med. 2019; :. doi: 10.1164/rccm.201908-1615ED. PubMed PMID:31532227 .
  2. Brochard, L, Yoshida, T, Amato, M. Reply to: Simple Electrical Impedance Tomography Measures for the Assessment of Ventilation Distribution. Am. J. Respir. Crit. Care Med. 2019; :. doi: 10.1164/rccm.201908-1645LE. PubMed PMID:31526321 .
  3. Lewis, KA, Chaudhuri, D, Guyatt, G, Burns, KEA, Bosma, K, Ge, L et al.. Comparison of ventilatory modes to facilitate liberation from mechanical ventilation: protocol for a systematic review and network meta-analysis. BMJ Open. 2019;9 (9):e030407. doi: 10.1136/bmjopen-2019-030407. PubMed PMID:31492786 .
  4. Vaporidi, K, Akoumianaki, E, Telias, I, Goligher, EC, Brochard, L, Georgopoulos, D et al.. Respiratory Drive in Critically Ill Patients: Pathophysiology and Clinical Implications. Am. J. Respir. Crit. Care Med. 2019; :. doi: 10.1164/rccm.201903-0596SO. PubMed PMID:31437406 .
  5. Orser, BA, Brochard, L. In Memoriam: Brian Kavanagh, 1962 to 2019. Anesthesiology. 2019; :. doi: 10.1097/ALN.0000000000002944. PubMed PMID:31436547 .
  6. Yoshida, T, Kavanagh, BP, Brochard, L. Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome. N. Engl. J. Med. 2019;381 (8):786-787. doi: 10.1056/NEJMc1908874. PubMed PMID:31433933 .
  7. Goligher, EC, Combes, A, Brodie, D, Ferguson, ND, Pesenti, AM, Ranieri, VM et al.. Determinants of the effect of extracorporeal carbon dioxide removal in the SUPERNOVA trial: implications for trial design. Intensive Care Med. 2019;45 (9):1219-1230. doi: 10.1007/s00134-019-05708-9. PubMed PMID:31432216 .
  8. Piquilloud, L, Beloncle, F, Richard, JM, Mancebo, J, Mercat, A, Brochard, L et al.. Information conveyed by electrical diaphragmatic activity during unstressed, stressed and assisted spontaneous breathing: a physiological study. Ann Intensive Care. 2019;9 (1):89. doi: 10.1186/s13613-019-0564-1. PubMed PMID:31414251 PubMed Central PMC6692797.
  9. McNicholas, BA, Madotto, F, Pham, T, Rezoagli, E, Masterson, CH, Horie, S et al.. Demographics, management and outcome of women and men with Acute Respiratory Distress Syndrome in the LUNG SAFE prospective cohort study. Eur. Respir. J. 2019; :. doi: 10.1183/13993003.00609-2019. PubMed PMID:31346004 .
  10. Shi, ZH, Jonkman, A, de Vries, H, Jansen, D, Ottenheijm, C, Girbes, A et al.. Expiratory muscle dysfunction in critically ill patients: towards improved understanding. Intensive Care Med. 2019;45 (8):1061-1071. doi: 10.1007/s00134-019-05664-4. PubMed PMID:31236639 PubMed Central PMC6667683.
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Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group