Laurent J. Brochard


Scientist, Keenan Research Centre for Biomedical Science


Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Dres, M, Dubé, BP, Goligher, E, Vorona, S, Demiri, S, Morawiec, E et al.. Usefulness of Parasternal Intercostal Muscle Ultrasound during Weaning from Mechanical Ventilation. Anesthesiology. 2020; :. doi: 10.1097/ALN.0000000000003191. PubMed PMID:32084029 .
  2. Sklar, MC, Dres, M, Fan, E, Rubenfeld, GD, Scales, DC, Herridge, MS et al.. Association of Low Baseline Diaphragm Muscle Mass With Prolonged Mechanical Ventilation and Mortality Among Critically Ill Adults. JAMA Netw Open. 2020;3 (2):e1921520. doi: 10.1001/jamanetworkopen.2019.21520. PubMed PMID:32074293 .
  3. Zhang, B, Ratano, D, Brochard, LJ, Georgopoulos, D, Duffin, J, Long, M et al.. A physiology-based mathematical model for the selection of appropriate ventilator controls for lung and diaphragm protection. J Clin Monit Comput. 2020; :. doi: 10.1007/s10877-020-00479-x. PubMed PMID:32008149 .
  4. Derbakova, A, Khu, S, Ho, K, Lewis, C, Ma, T, Melo, LT et al.. Neck and Inspiratory Muscle Recruitment during Inspiratory Loading and Neck Flexion. Med Sci Sports Exerc. 2020; :. doi: 10.1249/MSS.0000000000002271. PubMed PMID:31977643 .
  5. Chaudhuri, D, Granton, D, Wang, DX, Einav, S, Helviz, Y, Mauri, T et al.. Moderate Certainty Evidence Suggests the Use of High-Flow Nasal Cannula Does Not Decrease Hypoxia When Compared With Conventional Oxygen Therapy in the Peri-Intubation Period: Results of a Systematic Review and Meta-Analysis. Crit. Care Med. 2020; :. doi: 10.1097/CCM.0000000000004217. PubMed PMID:31923025 .
  6. Yoshida, T, Grieco, DL, Brochard, L, Fujino, Y. Patient self-inflicted lung injury and positive end-expiratory pressure for safe spontaneous breathing. Curr Opin Crit Care. 2020;26 (1):59-65. doi: 10.1097/MCC.0000000000000691. PubMed PMID:31815775 .
  7. Savary, D, Drennan, IR, Badat, B, Grieco, DL, Piraino, T, Lesimple, A et al.. Gastric insufflation during cardiopulmonary resuscitation: A study in human cadavers. Resuscitation. 2020;146 :111-117. doi: 10.1016/j.resuscitation.2019.10.014. PubMed PMID:31730897 .
  8. Abrams, D, Schmidt, M, Pham, T, Beitler, JR, Fan, E, Goligher, EC et al.. Mechanical Ventilation for ARDS During Extracorporeal Life Support: Research and Practice. Am. J. Respir. Crit. Care Med. 2019; :. doi: 10.1164/rccm.201907-1283CI. PubMed PMID:31726013 .
  9. Bertoni, M, Telias, I, Urner, M, Long, M, Del Sorbo, L, Fan, E et al.. A novel non-invasive method to detect excessively high respiratory effort and dynamic transpulmonary driving pressure during mechanical ventilation. Crit Care. 2019;23 (1):346. doi: 10.1186/s13054-019-2617-0. PubMed PMID:31694692 PubMed Central PMC6836358.
  10. Mancebo, J, Goligher, E, Brochard, L. Spontaneous Breathing Trials and Successful Extubation. JAMA. 2019;322 (17):1716-1717. doi: 10.1001/jama.2019.14226. PubMed PMID:31688879 .
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Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group