Laurent J. Brochard

MD, HDR

Scientist

Biography

Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Rodrigues, A, Janssens, L, Langer, D, Matsumura, U, Rozenberg, D, Brochard, L et al.. Semi-automated Detection of the Timing of Respiratory Muscle Activity: Validation and First Application. Front Physiol. 2021;12 :794598. doi: 10.3389/fphys.2021.794598. PubMed PMID:35046839 PubMed Central PMC8762204.
  2. Abrams, D, Agerstrand, C, Beitler, JR, Karagiannidis, C, Madahar, P, Yip, NH et al.. Risks and Benefits of Ultra-Lung-Protective Invasive Mechanical Ventilation Strategies with a Focus on Extracorporeal Support. Am J Respir Crit Care Med. 2022; :. doi: 10.1164/rccm.202110-2252CP. PubMed PMID:35044901 .
  3. Martinez, FJ, Brochard, L, Bush, A, Donaldson, G, Han, MK. Advancing Global Respiratory Health, Sleep, and Critical Care: Editorial from the New American Journal of Respiratory and Critical Care Medicine Team. Am J Respir Crit Care Med. 2022;205 (1):i-ii. doi: 10.1164/rccm.202111-2650ED. PubMed PMID:34971340 .
  4. Bianchi, I, Grassi, A, Pham, T, Telias, I, Teggia Droghi, M, Vieira, F et al.. Reliability of plateau pressure during patient-triggered assisted ventilation. Analysis of a multicentre database. J Crit Care. 2021;68 :96-103. doi: 10.1016/j.jcrc.2021.12.002. PubMed PMID:34952477 .
  5. Damiani, LF, Engelberts, D, Bastia, L, Osada, K, Katira, BH, Otulakowski, G et al.. Impact of Reverse Triggering Dyssynchrony During Lung-Protective Ventilation on Diaphragm Function: An Experimental Model. Am J Respir Crit Care Med. 2021; :. doi: 10.1164/rccm.202105-1089OC. PubMed PMID:34941477 .
  6. Wedzicha, JA, Brochard, L, Donaldson, GC, Martinez, FD, Martinez, FJ. Ending on a Crescendo: Reflections on Seven Years of a Successful Journal. Am J Respir Crit Care Med. 2021;204 (12):1351-1352. doi: 10.1164/rccm.202111-2478ED. PubMed PMID:34908519 .
  7. Fernando, SM, Tran, A, Sadeghirad, B, Burns, KEA, Fan, E, Brodie, D et al.. Noninvasive respiratory support following extubation in critically ill adults: a systematic review and network meta-analysis. Intensive Care Med. 2021; :. doi: 10.1007/s00134-021-06581-1. PubMed PMID:34825256 .
  8. Melo, LT, Rodrigues, A, Cabral, EE, Tanaka, T, Goligher, EC, Brochard, L et al.. Prefrontal cortex activation during incremental inspiratory loading in healthy participants. Respir Physiol Neurobiol. 2022;296 :103827. doi: 10.1016/j.resp.2021.103827. PubMed PMID:34808586 .
  9. Stavi, D, Goffi, A, Al Shalabi, M, Piraino, T, Chen, L, Jackson, R et al.. The Pressure Paradox: Abdominal Compression to Detect Lung Hyperinflation in COVID-19 Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2022;205 (2):245-247. doi: 10.1164/rccm.202104-1062IM. PubMed PMID:34748470 PubMed Central PMC8787257.
  10. Lellouche, F, Lavoie-Bérard, CA, Rousseau, E, Bouchard, PA, Lefebvre, JC, Branson, R et al.. How to avoid an epidemic of endotracheal tube occlusion. Lancet Respir Med. 2021;9 (11):1215-1216. doi: 10.1016/S2213-2600(21)00404-5. PubMed PMID:34739886 PubMed Central PMC8563017.
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Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group
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