Laurent J. Brochard

MD, HDR

Scientist, Keenan Research Centre for Biomedical Science

Biography

Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Telias, I, Katira, BH, Brochard, L. Is the Prone Position Helpful During Spontaneous Breathing in Patients With COVID-19?. JAMA. 2020; :. doi: 10.1001/jama.2020.8539. PubMed PMID:32412579 .
  2. Chotirmall, SH, Martinez, FJ, Schumacker, PT, Cooke, CR, Seam, N, Brochard, L et al.. Life at the Editorial 'COVID Frontline': The ATS Journal Family. Am. J. Respir. Crit. Care Med. 2020; :. doi: 10.1164/rccm.202005-1516ED. PubMed PMID:32356668 .
  3. Ali, A, Watanabe, Y, Galasso, M, Watanabe, T, Chen, M, Fan, E et al.. An extracellular oxygen carrier during prolonged pulmonary preservation improves post-transplant lung function. J. Heart Lung Transplant. 2020; :. doi: 10.1016/j.healun.2020.03.027. PubMed PMID:32334946 .
  4. Pham, T, Laffey, J, Bellani, G, Brochard, L, van Haren, F. The authors reply. Crit. Care Med. 2020;48 (5):e432-e433. doi: 10.1097/CCM.0000000000004302. PubMed PMID:32301785 .
  5. Madotto, F, Rezoagli, E, Pham, T, Schmidt, M, McNicholas, B, Protti, A et al.. Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome: insights from the LUNG SAFE study. Crit Care. 2020;24 (1):125. doi: 10.1186/s13054-020-2826-6. PubMed PMID:32234077 PubMed Central PMC7110678.
  6. Chaudhuri, D, Granton, D, Wang, DX, Einav, S, Helviz, Y, Mauri, T et al.. Moderate Certainty Evidence Suggests the Use of High-Flow Nasal Cannula Does Not Decrease Hypoxia When Compared With Conventional Oxygen Therapy in the Peri-Intubation Period: Results of a Systematic Review and Meta-Analysis. Crit. Care Med. 2020;48 (4):571-578. doi: 10.1097/CCM.0000000000004217. PubMed PMID:32205604 .
  7. Pan, C, Chen, L, Lu, C, Zhang, W, Xia, JA, Sklar, MC et al.. Lung Recruitability in COVID-19-associated Acute Respiratory Distress Syndrome: A Single-Center Observational Study. Am. J. Respir. Crit. Care Med. 2020;201 (10):1294-1297. doi: 10.1164/rccm.202003-0527LE. PubMed PMID:32200645 PubMed Central PMC7233342.
  8. Georgopoulos, D, Brochard, L. Dissociation between the brain target and respiratory capacity in critically ill patients. Intensive Care Med. 2020;46 (5):1077-1078. doi: 10.1007/s00134-020-05983-x. PubMed PMID:32140735 .
  9. Telias, I, Junhasavasdikul, D, Rittayamai, N, Piquilloud, L, Chen, L, Ferguson, ND et al.. Airway Occlusion Pressure As an Estimate of Respiratory Drive and Inspiratory Effort during Assisted Ventilation. Am. J. Respir. Crit. Care Med. 2020;201 (9):1086-1098. doi: 10.1164/rccm.201907-1425OC. PubMed PMID:32097569 .
  10. Dres, M, Dubé, BP, Goligher, E, Vorona, S, Demiri, S, Morawiec, E et al.. Usefulness of Parasternal Intercostal Muscle Ultrasound during Weaning from Mechanical Ventilation. Anesthesiology. 2020;132 (5):1114-1125. doi: 10.1097/ALN.0000000000003191. PubMed PMID:32084029 .
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Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group
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