Laurent J. Brochard


Scientist, Keenan Research Centre for Biomedical Science


Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Mukhopadhyay, SK, Zara, M, Telias, I, Chen, L, Coudroy, R, Yoshida, T et al.. A Singular Spectrum Analysis-Based Data-Driven Technique for the Removal of Cardiogenic Oscillations in Esophageal Pressure Signals. IEEE J Transl Eng Health Med. 2020;8 :3300211. doi: 10.1109/JTEHM.2020.3012926. PubMed PMID:32782854 PubMed Central PMC7413324.
  2. Jonkman, AH, Rauseo, M, Carteaux, G, Telias, I, Sklar, MC, Heunks, L et al.. Proportional modes of ventilation: technology to assist physiology. Intensive Care Med. 2020; :. doi: 10.1007/s00134-020-06206-z. PubMed PMID:32780167 PubMed Central PMC7417783.
  3. Adler, D, Cavalot, G, Brochard, L. Comorbidities and Readmissions in Survivors of Acute Hypercapnic Respiratory Failure. Semin Respir Crit Care Med. 2020; :. doi: 10.1055/s-0040-1710074. PubMed PMID:32746468 .
  4. Dianti, J, Angriman, F, Ferreyro, BL, Sklar, MC, Brochard, L, Ferguson, ND et al.. Association of Mortality with Neuromuscular Blockade Differs According to Baseline Diaphragm Thickness. Am. J. Respir. Crit. Care Med. 2020; :. doi: 10.1164/rccm.202004-1157LE. PubMed PMID:32717150 .
  5. Coudroy, R, Vimpere, D, Aissaoui, N, Younan, R, Bailleul, C, Couteau-Chardon, A et al.. Prevalence of Complete Airway Closure According to Body Mass Index in Acute Respiratory Distress Syndrome: Pooled Cohort Analysis. Anesthesiology. 2020; :. doi: 10.1097/ALN.0000000000003444. PubMed PMID:32701573 .
  6. Han, JS, Mashari, A, Singh, D, Dianti, J, Goligher, E, Long, M et al.. Personalized Ventilation to Multiple Patients Using a Single Ventilator: Description and Proof of Concept. Crit Care Explor. 2020;2 (5):e0118. doi: 10.1097/CCE.0000000000000118. PubMed PMID:32671348 PubMed Central PMC7259561.
  7. Lellouche, F, Delorme, M, Brochard, L. Impact of Respiratory Rate and Dead Space in the Current Era of Lung Protective Mechanical Ventilation. Chest. 2020;158 (1):45-47. doi: 10.1016/j.chest.2020.02.033. PubMed PMID:32654726 .
  8. Fan, E, Beitler, JR, Brochard, L, Calfee, CS, Ferguson, ND, Slutsky, AS et al.. COVID-19-associated acute respiratory distress syndrome: is a different approach to management warranted?. Lancet Respir Med. 2020;8 (8):816-821. doi: 10.1016/S2213-2600(20)30304-0. PubMed PMID:32645311 PubMed Central PMC7338016.
  9. Citerio, G, Bakker, J, Brochard, L, Buchman, TG, Jaber, S, Mazzone, PJ et al.. Critical care journals during the COVID-19 pandemic: challenges and responsibilities. Intensive Care Med. 2020;46 (8):1521-1523. doi: 10.1007/s00134-020-06155-7. PubMed PMID:32632505 PubMed Central PMC7335762.
  10. Chaudhuri, D, Granton, D, Wang, DX, Burns, KEA, Helviz, Y, Einav, S et al.. High flow nasal cannula in the immediate post-operative period: a systematic review and meta-analysis. Chest. 2020; :. doi: 10.1016/j.chest.2020.06.038. PubMed PMID:32615190 .
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Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group