Laurent J. Brochard




Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Costa, ELV, Slutsky, A, Brochard, LJ, Brower, R, Serpa-Neto, A, Cavalcanti, AB et al.. Ventilatory Variables and Mechanical Power in Patients with Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2021; :. doi: 10.1164/rccm.202009-3467OC. PubMed PMID:33784486 .
  2. Kolb, M, Dinh-Xuan, AT, Brochard, L. Guideline directed management of COVID-19: Do's and Dont's. Eur Respir J. 2021; :. doi: 10.1183/13993003.00753-2021. PubMed PMID:33766949 PubMed Central PMC7996221.
  3. Nasa, P, Azoulay, E, Khanna, AK, Jain, R, Gupta, S, Javeri, Y et al.. Expert consensus statements for the management of COVID-19-related acute respiratory failure using a Delphi method. Crit Care. 2021;25 (1):106. doi: 10.1186/s13054-021-03491-y. PubMed PMID:33726819 PubMed Central PMC7962430.
  4. Tilmont, A, Coiffard, B, Yoshida, T, Daviet, F, Baumstarck, K, Brioude, G et al.. Oesophageal pressure as a surrogate of pleural pressure in mechanically ventilated patients. ERJ Open Res. 2021;7 (1):. doi: 10.1183/23120541.00646-2020. PubMed PMID:33718491 PubMed Central PMC7938048.
  5. Mellado Artigas, R, Damiani, LF, Piraino, T, Pham, T, Chen, L, Rauseo, M et al.. Reverse Triggering Dyssynchrony 24 h after Initiation of Mechanical Ventilation. Anesthesiology. 2021;134 (5):760-769. doi: 10.1097/ALN.0000000000003726. PubMed PMID:33662121 .
  6. Carteaux, G, Pons, M, Morin, F, Tuffet, S, Lesimple, A, Badat, B et al.. Continuous positive airway pressure for respiratory support during COVID-19 pandemic: a frugal approach from bench to bedside. Ann Intensive Care. 2021;11 (1):38. doi: 10.1186/s13613-021-00828-2. PubMed PMID:33655452 PubMed Central PMC7924341.
  7. Coiffard, B, Riegler, S, Sklar, MC, Dres, M, Vorona, S, Reid, WD et al.. Diaphragm echodensity in mechanically ventilated patients: a description of technique and outcomes. Crit Care. 2021;25 (1):64. doi: 10.1186/s13054-021-03494-9. PubMed PMID:33593412 PubMed Central PMC7884870.
  8. Pham, T, Montanya, J, Telias, I, Piraino, T, Magrans, R, Coudroy, R et al.. Automated detection and quantification of reverse triggering effort under mechanical ventilation. Crit Care. 2021;25 (1):60. doi: 10.1186/s13054-020-03387-3. PubMed PMID:33588912 PubMed Central PMC7883535.
  9. Mellado-Artigas, R, Ferreyro, BL, Angriman, F, Hernández-Sanz, M, Arruti, E, Torres, A et al.. High-flow nasal oxygen in patients with COVID-19-associated acute respiratory failure. Crit Care. 2021;25 (1):58. doi: 10.1186/s13054-021-03469-w. PubMed PMID:33573680 PubMed Central PMC7876530.
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Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group