Laurent J. Brochard

MD, HDR

Scientist

Biography

Research Interests

Mechanical ventilation, acute respiratory failure, patient-ventilator interaction, Acute Respiratory Distress Syndrome

Research Activities

Bench models: simulation of patient-ventilator interaction; performance assessment of mechanical ventilators and related devices.

Bench experimental studies: collaboration with several groups on acute lung injury
Physiological studies in critically ill patients (respiratory mechanics, respiratory muscle activity, sleep, etc.)
Epidemiological studies on mechanical ventilation
Randomized clinical trials on mechanical ventilation

Recent Publications

  1. Brault, C, Mancebo, J, Suarez Montero, JC, Bentall, T, Burns, KEA, Piraino, T et al.. The PROMIZING trial enrollment algorithm for early identification of patients ready for unassisted breathing. Crit Care. 2022;26 (1):188. doi: 10.1186/s13054-022-04063-4. PubMed PMID:35739553 .
  2. Telias, I, Brochard, LJ, Gattarello, S, Wunsch, H, Junhasavasdikul, D, Bosma, KJ et al.. The physiological underpinnings of life-saving respiratory support. Intensive Care Med. 2022; :. doi: 10.1007/s00134-022-06749-3. PubMed PMID:35690953 .
  3. Honorio, T, Brochard, L. Drained and undrained heat capacity of swelling clays. Phys Chem Chem Phys. 2022;24 (24):15003-15014. doi: 10.1039/d2cp01419j. PubMed PMID:35687497 .
  4. Mellado-Artigas, R, Ferrando, C, Martino, F, Delbove, A, Ferreyro, BL, Darreau, C et al.. Early intubation and patient-centered outcomes in septic shock: a secondary analysis of a prospective multicenter study. Crit Care. 2022;26 (1):163. doi: 10.1186/s13054-022-04029-6. PubMed PMID:35672860 .
  5. Chen, L, Grieco, DL, Beloncle, F, Chen, GQ, Tiribelli, N, Madotto, F et al.. Partition of respiratory mechanics in patients with acute respiratory distress syndrome and association with outcome: a multicentre clinical study. Intensive Care Med. 2022; :. doi: 10.1007/s00134-022-06724-y. PubMed PMID:35670818 .
  6. Vieira, F, Bezerra, FS, Coudroy, R, Schreiber, A, Telias, I, Dubo, S et al.. High Flow Nasal Cannula compared to Continuous Positive Airway Pressure: a bench and physiological study. J Appl Physiol (1985). 2022; :. doi: 10.1152/japplphysiol.00416.2021. PubMed PMID:35511720 .
  7. Jonkman, AH, Ranieri, VM, Brochard, L. Lung recruitment. Intensive Care Med. 2022; :. doi: 10.1007/s00134-022-06715-z. PubMed PMID:35499759 .
  8. Soussi, S, Sharma, D, Jüni, P, Lebovic, G, Brochard, L, Marshall, JC et al.. Identifying clinical subtypes in sepsis-survivors with different one-year outcomes: a secondary latent class analysis of the FROG-ICU cohort. Crit Care. 2022;26 (1):114. doi: 10.1186/s13054-022-03972-8. PubMed PMID:35449071 PubMed Central PMC9022336.
  9. Goligher, EC, Telias, I, Sahetya, SK, Baedorf-Kassis, E, Patel, BK, Yehya, N et al.. Physiology is Vital to Precision Medicine in ARDS and Sepsis. Am J Respir Crit Care Med. 2022; :. doi: 10.1164/rccm.202202-0230ED. PubMed PMID:35442864 .
  10. Chirico, RN, de Matos, NA, Castro, TF, Cândido, LDS, Miranda, AG, Costa, GP et al.. The exogenous surfactant pre-treatment attenuates ventilator-induced lung injury in adult rats. Respir Physiol Neurobiol. 2022;302 :103911. doi: 10.1016/j.resp.2022.103911. PubMed PMID:35430285 .
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Affiliations & Other Activities

  • Staff Physician, Critical Care Department, St. Michael’s Hospital
  • Keenan Chair in Critical Care and Respiratory Medicine, St. Michael’s Hospital and University of Toronto
  • Head, Interdepartmental Division of Critical Care Medicine, University of Toronto
  • Deputy Editor of the American Journal Of Respiratory and Critical Care Medicine
  • Head of the PLUG Working Group on pleural pressure (ESICM)
  • Former Head and Member of the REVA (European Research Network on Mechanical Ventilation)
  • Member of the Canadian Critical Care Trial Group
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