Mario Ostrowski

MD, FRCP

Scientist

Biography

My current research interests focus on the immunopathogenesis of Human Immunodeficiency Virus (HIV) /Acquired Immune Deficiency Syndrome (AIDS) and Hepatitis C Virus (HCV) and other virus infections including SARS-CoV-2. We are interested in understanding why chronic virus infections persist in the host. Current work is divided along the following lines:

  1. Examination of T cell immune response to HIV and HCV infection.
  2. Therapeutic and preventive vaccine strategies
  3. immunomodulation during virus infections

Recent Publications

  1. Liu, J, Budylowski, P, Samson, R, Griffin, BD, Babuadze, G, Rathod, B et al.. Preclinical evaluation of a SARS-CoV-2 mRNA vaccine PTX-COVID19-B. Sci Adv. 2022;8 (3):eabj9815. doi: 10.1126/sciadv.abj9815. PubMed PMID:35044832 .
  2. Zhan, W, Hatchette, T, Yue, F, Liu, J, Song, H, Zhao, H et al.. Impaired Memory B-Cell Response to Influenza Immunization in Patients With Common Variable Immunodeficiency (CVID). Pathog Immun. 2021;6 (2):105-118. doi: 10.20411/pai.v6i2.405. PubMed PMID:34988341 PubMed Central PMC8714177.
  3. Costiniuk, CT, Singer, J, Langlois, MA, Kulic, I, Needham, J, Burchell, A et al.. CTN 328: immunogenicity outcomes in people living with HIV in Canada following vaccination for COVID-19 (HIV-COV): protocol for an observational cohort study. BMJ Open. 2021;11 (12):e054208. doi: 10.1136/bmjopen-2021-054208. PubMed PMID:34916326 PubMed Central PMC8678543.
  4. Law, JC, Girard, M, Chao, GYC, Ward, LA, Isho, B, Rathod, B et al.. Persistence of T Cell and Antibody Responses to SARS-CoV-2 Up to 9 Months after Symptom Onset. J Immunol. 2022;208 (2):429-443. doi: 10.4049/jimmunol.2100727. PubMed PMID:34903642 .
  5. Liu, Y, Budylowski, P, Dong, S, Li, Z, Goroshko, S, Leung, LYT et al.. SARS-CoV-2-Reactive Mucosal B Cells in the Upper Respiratory Tract of Uninfected Individuals. J Immunol. 2021;207 (10):2581-2588. doi: 10.4049/jimmunol.2100606. PubMed PMID:34607939 .
  6. Rahman, AN, Liu, J, Mujib, S, Kidane, S, Ali, A, Szep, S et al.. Elevated glycolysis imparts functional ability to CD8+ T cells in HIV infection. Life Sci Alliance. 2021;4 (11):. doi: 10.26508/lsa.202101081. PubMed PMID:34548381 PubMed Central PMC8473722.
  7. Leung, LYT, Khan, S, Budylowski, P, Li, Z, Goroshko, S, Liu, Y et al.. Detection and Neutralization of SARS-CoV-2 Using Non-conventional Variable Lymphocyte Receptor Antibodies of the Evolutionarily Distant Sea Lamprey. Front Immunol. 2021;12 :659071. doi: 10.3389/fimmu.2021.659071. PubMed PMID:34234774 PubMed Central PMC8256154.
  8. Kinloch, NN, Ren, Y, Alberto, WDC, Dong, W, Khadka, P, Huang, SH et al.. Author Correction: HIV-1 diversity considerations in the application of the Intact Proviral DNA Assay (IPDA). Nat Commun. 2021;12 (1):2958. doi: 10.1038/s41467-021-23515-z. PubMed PMID:33986282 PubMed Central PMC8119429.
  9. Banerjee, A, El-Sayes, N, Budylowski, P, Jacob, RA, Richard, D, Maan, H et al.. Experimental and natural evidence of SARS-CoV-2-infection-induced activation of type I interferon responses. iScience. 2021;24 (5):102477. doi: 10.1016/j.isci.2021.102477. PubMed PMID:33937724 PubMed Central PMC8074517.
  10. Yao, Z, Drecun, L, Aboualizadeh, F, Kim, SJ, Li, Z, Wood, H et al.. A homogeneous split-luciferase assay for rapid and sensitive detection of anti-SARS CoV-2 antibodies. Nat Commun. 2021;12 (1):1806. doi: 10.1038/s41467-021-22102-6. PubMed PMID:33753733 PubMed Central PMC7985487.
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Affiliations & Other Activities

  • Infectious Disease Consultant, St. Michael’s Hospital
  • Professor, Department of Medicine, Immunology, Lab Medicine, Pathobiology, University of Toronto
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