Mario Ostrowski




My current research interests focus on the immunopathogenesis of Human Immunodeficiency Virus (HIV) /Acquired Immune Deficiency Syndrome (AIDS) and Hepatitis C Virus (HCV) and other virus infections including SARS-CoV-2. We are interested in understanding why chronic virus infections persist in the host. Current work is divided along the following lines:

  1. Examination of T cell immune response to HIV and HCV infection.
  2. Therapeutic and preventive vaccine strategies
  3. immunomodulation during virus infections

Recent Publications

  1. Banerjee, A, El-Sayes, N, Budylowski, P, Jacob, RA, Richard, D, Maan, H et al.. Experimental and natural evidence of SARS-CoV-2 infection-induced activation of type I interferon responses. iScience. 2021; :102477. doi: 10.1016/j.isci.2021.102477. PubMed PMID:33937724 PubMed Central PMC8074517.
  2. Yao, Z, Drecun, L, Aboualizadeh, F, Kim, SJ, Li, Z, Wood, H et al.. A homogeneous split-luciferase assay for rapid and sensitive detection of anti-SARS CoV-2 antibodies. Nat Commun. 2021;12 (1):1806. doi: 10.1038/s41467-021-22102-6. PubMed PMID:33753733 PubMed Central PMC7985487.
  3. Kinloch, NN, Ren, Y, Conce Alberto, WD, Dong, W, Khadka, P, Huang, SH et al.. HIV-1 diversity considerations in the application of the Intact Proviral DNA Assay (IPDA). Nat Commun. 2021;12 (1):165. doi: 10.1038/s41467-020-20442-3. PubMed PMID:33420062 PubMed Central PMC7794580.
  4. Muir, RT, Suthiphosuwan, S, Bharatha, A, Lin, A, Munoz, D, Ostrowski, M et al.. Reversible Small Vessel Vasculitis and Encephalitis in HIV Antiretroviral Resistance. J Neuropathol Exp Neurol. 2021;80 (1):89-92. doi: 10.1093/jnen/nlaa106. PubMed PMID:33212472 PubMed Central PMC7749715.
  5. Isho, B, Abe, KT, Zuo, M, Jamal, AJ, Rathod, B, Wang, JH et al.. Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients. Sci Immunol. 2020;5 (52):. doi: 10.1126/sciimmunol.abe5511. PubMed PMID:33033173 PubMed Central PMC8050884.
  6. Abe, KT, Li, Z, Samson, R, Samavarchi-Tehrani, P, Valcourt, EJ, Wood, H et al.. A simple protein-based surrogate neutralization assay for SARS-CoV-2. JCI Insight. 2020;5 (19):. doi: 10.1172/jci.insight.142362. PubMed PMID:32870820 PubMed Central PMC7566699.
  7. Zost, SJ, Gilchuk, P, Chen, RE, Case, JB, Reidy, JX, Trivette, A et al.. Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein. Nat Med. 2020;26 (9):1422-1427. doi: 10.1038/s41591-020-0998-x. PubMed PMID:32651581 .
  8. Jamal, AJ, Mozafarihashjin, M, Coomes, E, Powis, J, Li, AX, Paterson, A et al.. Sensitivity of Nasopharyngeal Swabs and Saliva for the Detection of Severe Acute Respiratory Syndrome Coronavirus 2. Clin Infect Dis. 2021;72 (6):1064-1066. doi: 10.1093/cid/ciaa848. PubMed PMID:32584972 PubMed Central PMC7337630.
  9. Banerjee, A, Nasir, JA, Budylowski, P, Yip, L, Aftanas, P, Christie, N et al.. Isolation, Sequence, Infectivity, and Replication Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2. Emerg Infect Dis. 2020;26 (9):2054-2063. doi: 10.3201/eid2609.201495. PubMed PMID:32558639 PubMed Central PMC7454076.
  10. Khan, S, Liu, Y, Ernst, LM, Leung, LYT, Budylowski, P, Dong, S et al.. Detection of Human CD38 Using Variable Lymphocyte Receptor (VLR) Tetramers. Cells. 2020;9 (4):. doi: 10.3390/cells9040950. PubMed PMID:32290546 PubMed Central PMC7226959.
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Affiliations & Other Activities

  • Infectious Disease Consultant, St. Michael’s Hospital
  • Professor, Department of Medicine, Immunology, Lab Medicine, Pathobiology, University of Toronto