Mario Ostrowski

MD, FRCP

Scientist

Biography

My current research interests focus on the immunopathogenesis of Human Immunodeficiency Virus (HIV) /Acquired Immune Deficiency Syndrome (AIDS) and Hepatitis C Virus (HCV) and other virus infections including SARS-CoV-2. We are interested in understanding why chronic virus infections persist in the host. Current work is divided along the following lines:

  1. Examination of T cell immune response to HIV and HCV infection.
  2. Therapeutic and preventive vaccine strategies
  3. immunomodulation during virus infections

Recent Publications

  1. Rahman, AN, Liu, J, Mujib, S, Kidane, S, Ali, A, Szep, S et al.. Elevated glycolysis imparts functional ability to CD8+ T cells in HIV infection. Life Sci Alliance. 2021;4 (11):. doi: 10.26508/lsa.202101081. PubMed PMID:34548381 .
  2. Leung, LYT, Khan, S, Budylowski, P, Li, Z, Goroshko, S, Liu, Y et al.. Detection and Neutralization of SARS-CoV-2 Using Non-conventional Variable Lymphocyte Receptor Antibodies of the Evolutionarily Distant Sea Lamprey. Front Immunol. 2021;12 :659071. doi: 10.3389/fimmu.2021.659071. PubMed PMID:34234774 PubMed Central PMC8256154.
  3. Kinloch, NN, Ren, Y, Alberto, WDC, Dong, W, Khadka, P, Huang, SH et al.. Author Correction: HIV-1 diversity considerations in the application of the Intact Proviral DNA Assay (IPDA). Nat Commun. 2021;12 (1):2958. doi: 10.1038/s41467-021-23515-z. PubMed PMID:33986282 PubMed Central PMC8119429.
  4. Banerjee, A, El-Sayes, N, Budylowski, P, Jacob, RA, Richard, D, Maan, H et al.. Experimental and natural evidence of SARS-CoV-2-infection-induced activation of type I interferon responses. iScience. 2021;24 (5):102477. doi: 10.1016/j.isci.2021.102477. PubMed PMID:33937724 PubMed Central PMC8074517.
  5. Yao, Z, Drecun, L, Aboualizadeh, F, Kim, SJ, Li, Z, Wood, H et al.. A homogeneous split-luciferase assay for rapid and sensitive detection of anti-SARS CoV-2 antibodies. Nat Commun. 2021;12 (1):1806. doi: 10.1038/s41467-021-22102-6. PubMed PMID:33753733 PubMed Central PMC7985487.
  6. Kinloch, NN, Ren, Y, Conce Alberto, WD, Dong, W, Khadka, P, Huang, SH et al.. HIV-1 diversity considerations in the application of the Intact Proviral DNA Assay (IPDA). Nat Commun. 2021;12 (1):165. doi: 10.1038/s41467-020-20442-3. PubMed PMID:33420062 PubMed Central PMC7794580.
  7. Muir, RT, Suthiphosuwan, S, Bharatha, A, Lin, A, Munoz, D, Ostrowski, M et al.. Reversible Small Vessel Vasculitis and Encephalitis in HIV Antiretroviral Resistance. J Neuropathol Exp Neurol. 2021;80 (1):89-92. doi: 10.1093/jnen/nlaa106. PubMed PMID:33212472 PubMed Central PMC7749715.
  8. Isho, B, Abe, KT, Zuo, M, Jamal, AJ, Rathod, B, Wang, JH et al.. Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients. Sci Immunol. 2020;5 (52):. doi: 10.1126/sciimmunol.abe5511. PubMed PMID:33033173 PubMed Central PMC8050884.
  9. Abe, KT, Li, Z, Samson, R, Samavarchi-Tehrani, P, Valcourt, EJ, Wood, H et al.. A simple protein-based surrogate neutralization assay for SARS-CoV-2. JCI Insight. 2020;5 (19):. doi: 10.1172/jci.insight.142362. PubMed PMID:32870820 PubMed Central PMC7566699.
  10. Zost, SJ, Gilchuk, P, Chen, RE, Case, JB, Reidy, JX, Trivette, A et al.. Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein. Nat Med. 2020;26 (9):1422-1427. doi: 10.1038/s41591-020-0998-x. PubMed PMID:32651581 PubMed Central PMC8194108.
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Affiliations & Other Activities

  • Infectious Disease Consultant, St. Michael’s Hospital
  • Professor, Department of Medicine, Immunology, Lab Medicine, Pathobiology, University of Toronto
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