Pamela Plant

PhD

Adjunct Scientist, Keenan Research Centre for Biomedical Science

Biography

Dr. Plant is an Adjunct Scientist and Genomics Specialist at the Keenan Research Center for Biomedical Science at Unity Health Toronto (SMH). She obtained her Ph.D. at the University of Toronto in the Department of Biochemistry followed by fellowships at the CHUV, University of Lausanne and the Lunenfeld Institute at Mt Sinai Hospital. Pamela has been with St. Michael’s for over 10 years where she has developed her interest in molecular diagnostics research and has published over 40 peer-reviewed articles. As an application scientist in the area of molecular biology and biochemistry she provides support to the research community with experimental design, data acquisition, analysis and representation. She has helped to bring in millions of dollars of vital new infrastructure to the Institute and is dedicated to integrating these innovative technologies in the KRCBS. She has sat on numerous committees such as the Research Training Center and Biosafety Committee. Pamela is passionate about trainee education and began the Research Core Facilities “Core Clinics” educational program, where RCF Specialists run dozens of unique courses for trainees in a broad range of basic science techniques. She has been dedicated to promoting scientific literacy in the community through involvement in scientific outreach programs for high school students, in Pathways to Education and Women in STEM programs through the public library system. Pamela lectures at the University of Toronto Institute for Medical Science with a focus on graduate professional development.

Recent Publications

  1. Walsh, CJ, Escudero King, C, Gupta, M, Plant, PJ, Herridge, MJ, Mathur, S et al.. MicroRNA regulatory networks associated with abnormal muscle repair in survivors of critical illness. J Cachexia Sarcopenia Muscle. 2022;13 (2):1262-1276. doi: 10.1002/jcsm.12903. PubMed PMID:35092190 PubMed Central PMC8977950.
  2. Ramadan, A, Singh, KK, Quan, A, Plant, PJ, Al-Omran, M, Teoh, H et al.. Loss of vascular smooth muscle cell autophagy exacerbates angiotensin II-associated aortic remodeling. J Vasc Surg. 2018;68 (3):859-871. doi: 10.1016/j.jvs.2017.08.086. PubMed PMID:29273297 .
  3. D'Cruz, R, Plant, PJ, Pablo, LA, Lin, S, Chackowicz, J, Correa, J et al.. PDLIM7 is a novel target of the ubiquitin ligase Nedd4-1 in skeletal muscle. Biochem J. 2016;473 (3):267-76. doi: 10.1042/BJ20150222. PubMed PMID:26556890 .
  4. Nagpal, P, Plant, PJ, Correa, J, Bain, A, Takeda, M, Kawabe, H et al.. The ubiquitin ligase Nedd4-1 participates in denervation-induced skeletal muscle atrophy in mice. PLoS One. 2012;7 (10):e46427. doi: 10.1371/journal.pone.0046427. PubMed PMID:23110050 PubMed Central PMC3482220.
  5. Plant, PJ, North, ML, Ward, A, Ward, M, Khanna, N, Correa, J et al.. Hypertrophic airway smooth muscle mass correlates with increased airway responsiveness in a murine model of asthma. Am J Respir Cell Mol Biol. 2012;46 (4):532-40. doi: 10.1165/rcmb.2011-0293OC. PubMed PMID:22108300 .
  6. Plant, PJ, Brooks, D, Faughnan, M, Bayley, T, Bain, J, Singer, L et al.. Cellular markers of muscle atrophy in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2010;42 (4):461-71. doi: 10.1165/rcmb.2008-0382OC. PubMed PMID:19520920 .
  7. Plant, PJ, Bain, JR, Correa, JE, Woo, M, Batt, J. Absence of caspase-3 protects against denervation-induced skeletal muscle atrophy. J Appl Physiol (1985). 2009;107 (1):224-34. doi: 10.1152/japplphysiol.90932.2008. PubMed PMID:19390003 .
  8. Plant, PJ, Correa, J, Goldenberg, N, Bain, J, Batt, J. The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4. Biochem J. 2009;419 (1):57-63. doi: 10.1042/BJ20081866. PubMed PMID:19125695 PubMed Central PMC2657291.
  9. Plant, PJ, Fawcett, JP, Lin, DC, Holdorf, AD, Binns, K, Kulkarni, S et al.. A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl. Nat Cell Biol. 2003;5 (4):301-8. doi: 10.1038/ncb948. PubMed PMID:12629547 .
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Affiliations & Other Activities

  • University of Toronto
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