Philip Connelly


Affiliate Scientist


Dr. Phil Connelly is a Staff Scientist in the Keenan Research Centre for Biomedical Science of St. Michael’s Hospital. He has a primary academic appointment in the Department of Medicine at the University of Toronto, as well as a graduate appointment in the Department of Laboratory Medicine and Pathobiology. Dr. Connelly’s current basic research is focused on the metabolism of hydroxy fatty aldehydes. The chemistry of this system involves glutathione and the products are readily exported from the cells to undergo further metabolism. The products are known to be proinflammatory and, we hypothesize, atherothrombotic.

Collaborative research on patient populations is focused on renal transplant recipients, women with gestational diabetes and subjects with pre-diabetes.

Recent Publications

  1. Semnani-Azad, Z, Connelly, PW, Bazinet, RP, Retnakaran, R, Jenkins, DJA, Harris, SB et al.. Adipose Tissue Insulin Resistance Is Longitudinally Associated With Adipose Tissue Dysfunction, Circulating Lipids, and Dysglycemia: The PROMISE Cohort. Diabetes Care. 2021; :. doi: 10.2337/dc20-1918. PubMed PMID:34001534 .
  2. Semnani-Azad, Z, Blanco Mejia, S, Connelly, PW, Bazinet, RP, Retnakaran, R, Jenkins, DJA et al.. The association of soluble CD163, a novel biomarker of macrophage activation, with type 2 diabetes mellitus and its underlying physiological disorders: A systematic review. Obes Rev. 2021;22 (9):e13257. doi: 10.1111/obr.13257. PubMed PMID:33913230 .
  3. Mutch, DM, Lowry, DE, Roth, M, Sihag, J, Hammad, SS, Taylor, CG et al.. Polymorphisms in the stearoyl-CoA desaturase gene modify blood glucose response to dietary oils varying in MUFA content in adults with obesity. Br J Nutr. 2021; :1-10. doi: 10.1017/S0007114521001264. PubMed PMID:33829984 .
  4. Hashi, AA, Ramesh Prasad, GV, Connelly, PW, Deva, DP, Nash, MM, Yuan, W et al.. Cardiac MRI assessment of the right ventricle pre-and post-kidney transplant. Int J Cardiovasc Imaging. 2021;37 (5):1757-1766. doi: 10.1007/s10554-020-02153-4. PubMed PMID:33475872 .
  5. Huang, F, Connelly, PW, Prasad, GVR, Nash, MM, Gunaratnam, L, Deva, DP et al.. Evaluation of left atrial remodeling in kidney transplant patients using cardiac magnetic resonance imaging. J Nephrol. 2021;34 (3):851-859. doi: 10.1007/s40620-020-00853-7. PubMed PMID:32910428 .
  6. Semnani-Azad, Z, Johnston, LW, Lee, C, Retnakaran, R, Connelly, PW, Harris, SB et al.. Determinants of longitudinal change in insulin clearance: the Prospective Metabolism and Islet Cell Evaluation cohort. BMJ Open Diabetes Res Care. 2019;7 (1):e000825. doi: 10.1136/bmjdrc-2019-000825. PubMed PMID:31803485 PubMed Central PMC6887510.
  7. Volpe, A, Ye, C, Hanley, AJ, Connelly, PW, Zinman, B, Retnakaran, R et al.. Changes Over Time in Uric Acid in Relation to Changes in Insulin Sensitivity, Beta-Cell Function, and Glycemia. J Clin Endocrinol Metab. 2020;105 (3):. doi: 10.1210/clinem/dgz199. PubMed PMID:31720687 PubMed Central PMC7025949.
  8. Mazer, CD, Hare, GMT, Connelly, PW, Gilbert, RE, Shehata, N, Quan, A et al.. Effect of Empagliflozin on Erythropoietin Levels, Iron Stores, and Red Blood Cell Morphology in Patients With Type 2 Diabetes Mellitus and Coronary Artery Disease. Circulation. 2020;141 (8):704-707. doi: 10.1161/CIRCULATIONAHA.119.044235. PubMed PMID:31707794 .
  9. Semnani-Azad, Z, Connelly, PW, Johnston, LW, Retnakaran, R, Harris, SB, Zinman, B et al.. The Macrophage Activation Marker Soluble CD163 is Longitudinally Associated With Insulin Sensitivity and β-cell Function. J Clin Endocrinol Metab. 2020;105 (3):. doi: 10.1210/clinem/dgz166. PubMed PMID:31677389 PubMed Central PMC7112970.
  10. Retnakaran, R, Ye, C, Hanley, AJ, Connelly, PW, Sermer, M, Zinman, B et al.. Screening Glucose Challenge Test in Pregnancy Can Identify Women With an Adverse Postpartum Cardiovascular Risk Factor Profile: Implications for Cardiovascular Risk Reduction. J Am Heart Assoc. 2019;8 (21):e014231. doi: 10.1161/JAHA.119.014231. PubMed PMID:31657272 PubMed Central PMC6898826.
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Affiliations & Other Activities

  • Director, J. Alick Little Lipid Research Laboratory, St. Michael’s Hospital
  • Professor, Department of Medicine, Division of Endocrinology, University of Toronto
  • Professor, Laboratory Medicine and Pathobiology, University of Toronto