Raphael Schneider


Investigator, Li Ka Shing Knowledge Institute


Dr. Raphael Schneider is a neurologist and researcher working in the BARLO MS Centre at St. Michael’s Hospital. He is an assistant professor at the University of Toronto in both the Department of Medicine and the Institute of Medical Science. He completed a Ph.D. in the Department of Laboratory Medicine and Pathobiology (neuroscience) at the University of Toronto, focusing on extracellular vesicles as biomarkers in neurological diseases and a postdoctoral fellowship in neuroimmunology at the Université de Montréal where he studied the role of CD8+ T lymphocytes in multiple sclerosis (MS). Before joining the MS group at St. Michael’s Hospital, Dr. Schneider completed the Clinical Investigator Program of the Royal College of Physicians and Surgeons of Canada supported by a Phillipson Clinician-Scientist scholarship.

Dr. Schneider’s primary research focus is finding new blood and spinal fluid biomarkers for people with MS. He is particularly interested in early diagnosis and estimation of prognosis. He has recently been awarded a Slamen-Fast New Initiatives in Neurology Award and a Medical Research Grant from the J.P. Bickell Foundation.

Recent Publications

  1. Gilani, K, Kuntz, S, Munoz, DG, Schneider, R. Pearls & Oy-sters: Rosai-Dorfman Disease of the Central Nervous System. Neurology. 2021; :. doi: 10.1212/WNL.0000000000012035. PubMed PMID:33849989 .
  2. Lincoln, MR, Schneider, R, Oh, J. Vitamin D as disease-modifying therapy for multiple sclerosis?. Expert Rev Clin Immunol. 2021;17 (7):691-693. doi: 10.1080/1744666X.2021.1915772. PubMed PMID:33836645 .
  3. Watt, JA, Goodarzi, Z, Veroniki, AA, Nincic, V, Khan, PA, Ghassemi, M et al.. Comparative efficacy of interventions for reducing symptoms of depression in people with dementia: systematic review and network meta-analysis. BMJ. 2021;372 :n532. doi: 10.1136/bmj.n532. PubMed PMID:33762262 PubMed Central PMC7988455.
  4. Muir, RT, Suthiphosuwan, S, Bharatha, A, Lin, A, Munoz, D, Ostrowski, M et al.. Reversible Small Vessel Vasculitis and Encephalitis in HIV Antiretroviral Resistance. J Neuropathol Exp Neurol. 2021;80 (1):89-92. doi: 10.1093/jnen/nlaa106. PubMed PMID:33212472 PubMed Central PMC7749715.
  5. Théry, C, Witwer, KW, Aikawa, E, Alcaraz, MJ, Anderson, JD, Andriantsitohaina, R et al.. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles. 2018;7 (1):1535750. doi: 10.1080/20013078.2018.1535750. PubMed PMID:30637094 PubMed Central PMC6322352.
  6. Zhang, M, Ferrari, R, Tartaglia, MC, Keith, J, Surace, EI, Wolf, U et al.. A C6orf10/LOC101929163 locus is associated with age of onset in C9orf72 carriers. Brain. 2018;141 (10):2895-2907. doi: 10.1093/brain/awy238. PubMed PMID:30252044 PubMed Central PMC6158742.
  7. Schneider, R. CIM Journal Club: Gene therapy for spinal muscular atrophy Comment on Mendell et al. N Engl J Med 2017;377:1713-22. Clin Invest Med. 2018;41 (1):E31-E33. doi: 10.25011/cim.v41i1.29461. PubMed PMID:29603689 .
  8. McKeever, PM, Schneider, R, Taghdiri, F, Weichert, A, Multani, N, Brown, RA et al.. MicroRNA Expression Levels Are Altered in the Cerebrospinal Fluid of Patients with Young-Onset Alzheimer's Disease. Mol Neurobiol. 2018;55 (12):8826-8841. doi: 10.1007/s12035-018-1032-x. PubMed PMID:29603092 PubMed Central PMC6208843.
  9. Schneider, R, Weichert, A, Rogaeva, E, Robertson, J, Keith, J, Zinman, L et al.. Clinical Reasoning: A 42-year-old man with unilateral leg weakness. Neurology. 2018;90 (12):e1085-e1090. doi: 10.1212/WNL.0000000000005179. PubMed PMID:29555890 .
  10. Schneider, R, McKeever, P, Kim, T, Graff, C, van Swieten, JC, Karydas, A et al.. Downregulation of exosomal miR-204-5p and miR-632 as a biomarker for FTD: a GENFI study. J Neurol Neurosurg Psychiatry. 2018;89 (8):851-858. doi: 10.1136/jnnp-2017-317492. PubMed PMID:29434051 PubMed Central PMC6045452.
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Affiliations & Other Activities

  • Assistant Professor, Department of Medicine, University of Toronto
  • Assistant Professor, Institute of Medical Science, University of Toronto