Richard S. T. Leung




Research Interests

Sleep apnea, Cheyne-Stokes respiration, autonomic nervous system, heart rate variability

Research Activities

My main area of interest is the autonomic and cardiac effects of sleep apnea. In particular, I am interested in the ways sleep apnea can cause arrhythmias and other cardiac diseases. I perform both physiological studies in patients and healthy volunteers, as well as epidemiologic studies.

Recent Publications

  1. Ahmad, A, Ahmad, R, Meteb, M, Ryan, CM, Leung, RS, Montandon, G et al.. The relationship between opioid use and obstructive sleep apnea: A systematic review and meta-analysis. Sleep Med Rev. 2021;58 :101441. doi: 10.1016/j.smrv.2021.101441. PubMed PMID:33567395 .
  2. Kendzerska, T, Povitz, M, Leung, RS, Boulos, MI, McIsaac, DI, Murray, BJ et al.. Obstructive Sleep Apnea and Incident Cancer: A Large Retrospective Multicenter Clinical Cohort Study. Cancer Epidemiol Biomarkers Prev. 2021;30 (2):295-304. doi: 10.1158/1055-9965.EPI-20-0975. PubMed PMID:33268490 PubMed Central PMC7867627.
  3. Kendzerska, T, Leung, RS, Atzema, CL, Chandy, G, Meteb, M, Malhotra, A et al.. Cardiovascular consequences of obstructive sleep apnea in women: a historical cohort study. Sleep Med. 2020;68 :71-79. doi: 10.1016/j.sleep.2019.08.021. PubMed PMID:32028229 PubMed Central PMC7075717.
  4. Perger, E, Lyons, OD, Inami, T, Smith, S, Floras, JS, Logan, AG et al.. Predictors of 1-year compliance with adaptive servoventilation in patients with heart failure and sleep disordered breathing: preliminary data from the ADVENT-HF trial. Eur Respir J. 2019;53 (2):. doi: 10.1183/13993003.01626-2018. PubMed PMID:30409822 .
  5. Kendzerska, T, Leung, RS, Aaron, SD, Ayas, N, Sandoz, JS, Gershon, AS et al.. Cardiovascular Outcomes and All-Cause Mortality in Patients with Obstructive Sleep Apnea and Chronic Obstructive Pulmonary Disease (Overlap Syndrome). Ann Am Thorac Soc. 2019;16 (1):71-81. doi: 10.1513/AnnalsATS.201802-136OC. PubMed PMID:30372124 .
  6. Leung, RS. Arousability in Obstructive Sleep Apnea: Friend or Foe?. Am J Respir Crit Care Med. 2019;199 (7):821-822. doi: 10.1164/rccm.201810-1935ED. PubMed PMID:30372123 PubMed Central PMC6444655.
  7. Kendzerska, T, Gershon, AS, Atzema, C, Dorian, P, Mangat, I, Hawker, G et al.. Sleep Apnea Increases the Risk of New Hospitalized Atrial Fibrillation: A Historical Cohort Study. Chest. 2018;154 (6):1330-1339. doi: 10.1016/j.chest.2018.08.1075. PubMed PMID:30243978 .
  8. Perger, E, Inami, T, Lyons, OD, Alshaer, H, Smith, S, Floras, JS et al.. Distinct Patterns of Hyperpnea During Cheyne-Stokes Respiration: Implication for Cardiac Function in Patients With Heart Failure. J Clin Sleep Med. 2017;13 (11):1235-1241. doi: 10.5664/jcsm.6788. PubMed PMID:29065956 PubMed Central PMC5656472.
  9. Kendzerska, T, Gershon, AS, Hawker, GA, Tomlinson, GA, Leung, RS. Obstructive sleep apnoea is not a risk factor for incident hospitalised depression: a historical cohort study. Eur Respir J. 2017;49 (6):. doi: 10.1183/13993003.01361-2016. PubMed PMID:28572118 .
  10. Lyons, OD, Floras, JS, Logan, AG, Beanlands, R, Cantolla, JD, Fitzpatrick, M et al.. Design of the effect of adaptive servo-ventilation on survival and cardiovascular hospital admissions in patients with heart failure and sleep apnoea: the ADVENT-HF trial. Eur J Heart Fail. 2017;19 (4):579-587. doi: 10.1002/ejhf.790. PubMed PMID:28371141 .
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Affiliations & Other Activities

  • Director, Sleep Laboratory, St. Michael’s Hospital
  • Staff Physician, Division of Respirology, St. Michael’s Hospital
  • Assistant Professor, Department of Medicine, University of Toronto
  • Program Committee, Sleep and Respiratory Neurobiology Section, American Thoracic Society