Sidney Kennedy



Research Programs


Dr. Sidney H. Kennedy is Professor of Psychiatry at the University of Toronto, the Arthur Sommer Rotenberg Chair in Suicide and Depression Studies, and a Scientist at Li Ka Shing Knowledge Institute and Toronto Western Research Institute, Toronto, Canada. Dr. Kennedy is the lead investigator for a large depression biomarker initiative. He has published extensively on new drug evaluation, neuroimaging and neurostimulation therapies, personality factors in depression, antidepressant effects on sexual function and treatment guidelines for Major Depressive Disorder and Bipolar Disorder.

Dr. Kennedy is the Immediate Past President of the International Society for Affective Disorders, former President of the Canadian College of Neuropsychopharmacology, and the founding chair of the Canadian Network for Mood and Anxiety Treatments (CANMAT).

He has published more than 350 peer reviewed publications and 11 books on depression and related topics.

Recent Publications

  1. Marshe, VS, Maciukiewicz, M, Hauschild, AC, Islam, F, Qin, L, Tiwari, AK et al.. Genome-wide analysis suggests the importance of vascular processes and neuroinflammation in late-life antidepressant response. Transl Psychiatry. 2021;11 (1):127. doi: 10.1038/s41398-021-01248-3. PubMed PMID:33589590 .
  2. Rybak, YE, Lai, KSP, Ramasubbu, R, Blumberger, DM, Chan, P, Delva, N et al.. Treatment-resistant major depressive disorder: Canadian expert consensus on definition and assessment. Depress Anxiety. 2021; :. doi: 10.1002/da.23135. PubMed PMID:33528865 .
  3. Vaccarino, AL, Kalali, AH, Blier, P, Gilbert Evans, S, Engelhardt, N, Foster, JA et al.. THE DEPRESSION INVENTORY DEVELOPMENT SCALE: Assessment of Psychometric Properties Using Classical and Modern Measurement Theory in a CAN-BIND Trial. Innov Clin Neurosci. 2020;17 (7-9):30-40. . PubMed PMID:33520402 PubMed Central PMC7839654.
  4. Farris, MS, Braun, A, MacQueen, G, Goldstein, BI, Wang, J, Kennedy, SH et al.. Longitudinal Trends in Medication Treatment for Youth At-Risk for Serious Mental Illness. Can J Psychiatry. 2021; :706743720988450. doi: 10.1177/0706743720988450. PubMed PMID:33464130 .
  5. Ohuma, EO, Young, MF, Martorell, R, Ismail, LC, Peña-Rosas, JP, Purwar, M et al.. International values for haemoglobin distributions in healthy pregnant women. EClinicalMedicine. 2020;29-30 :100660. doi: 10.1016/j.eclinm.2020.100660. PubMed PMID:33437954 PubMed Central PMC7788439.
  6. McInerney, SJ, Chakrabarty, T, Maciukiewicz, M, Frey, BN, MacQueen, GM, Milev, RV et al.. Cognition and Its Association with Psychosocial and Occupational Functioning during Treatment with Escitalopram in Patients with Major Depressive Disorder: A CAN-BIND-1 Report: La Cognition Et Son Association Avec Le Fonctionnement Psychosocial Et Professionnel Durant Le Traitement Par Escitalopram Chez Des Patients Souffrant De Trouble Dépressif Majeur: Une Étude Can-Bind-1. Can J Psychiatry. 2020; :706743720974823. doi: 10.1177/0706743720974823. PubMed PMID:33353384 .
  7. Ge, R, Hassel, S, Arnott, SR, Davis, AD, Harris, JK, Zamyadi, M et al.. Structural covariance pattern abnormalities of insula in major depressive disorder: A CAN-BIND study report. Prog Neuropsychopharmacol Biol Psychiatry. 2020; :110194. doi: 10.1016/j.pnpbp.2020.110194. PubMed PMID:33296696 .
  8. Uher, R, Lam, RW, Kennedy, SH. Dr Uher and Colleagues Reply. J Clin Psychiatry. 2020;82 (1):. doi: 10.4088/JCP.20lr13628a. PubMed PMID:33296151 .
  9. Metzak, PD, Addington, J, Hassel, S, Goldstein, BI, MacIntosh, BJ, Lebel, C et al.. Functional imaging in youth at risk for transdiagnostic serious mental illness: Initial results from the PROCAN study. Early Interv Psychiatry. 2020; :. doi: 10.1111/eip.13078. PubMed PMID:33295151 .
  10. Dodd, S, Bauer, M, Carvalho, AF, Eyre, H, Fava, M, Kasper, S et al.. A clinical approach to treatment resistance in depressed patients: What to do when the usual treatments don't work well enough?. World J Biol Psychiatry. 2020; :1-20. doi: 10.1080/15622975.2020.1851052. PubMed PMID:33289425 .
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Affiliations & Other Activities

  • Staff Physician, Department of Mental Health, St. Michael’s Hospital
  • Professor, Department of Psychiatry, University of Toronto
  • Research Scientist, Krembil Neurosciences, University Health Network