Sidney Kennedy



Research Programs


Sidney H. Kennedy is Professor of Psychiatry and Arthur Sommer Rotenberg Chair in Depression and Suicide Studies at the University of Toronto, Director of the Centre for Suicide and Depression Studies at St. Michael’s Hospital, and a Scientist at Li Ka Shing Knowledge Institute and Krembil Research Institute in Toronto. Dr. Kennedy is the lead investigator for the Canadian Biomarker Integration Network in Depression (CAN-BIND), a national depression biomarker initiative. He has published extensively on new drug evaluation, neuroimaging and neurostimulation therapies, personality factors in depression, antidepressant effects on sexual function, and treatment guidelines for Major Depressive Disorder and Bipolar Disorder.

Dr. Kennedy is the Immediate Past President of the International Society for Affective Disorders, former President of the Canadian College of Neuropsychopharmacology, and the founding chair of the Canadian Network for Mood and Anxiety Treatments (CANMAT).

Dr. Kennedy has authored close to 500 peer-reviewed publications and 11 books on depression and related topics. He is a Fellow of the Canadian Academy of Health Sciences and the Royal Society of Canada.

Recent Publications

  1. Curtis, EM, Parsons, C, Maslin, K, D'Angelo, S, Moon, RJ, Crozier, SR et al.. Bone turnover in pregnancy, measured by urinary C-terminal telopeptide of type I collagen (CTX), is influenced by vitamin D supplementation and is associated with maternal bone health: Findings from the MAVIDOS trial. Am J Clin Nutr. 2021; :. doi: 10.1093/ajcn/nqab264. PubMed PMID:34297067 .
  2. Caspani, G, Turecki, G, Lam, RW, Milev, RV, Frey, BN, MacQueen, GM et al.. Metabolomic signatures associated with depression and predictors of antidepressant response in humans: A CAN-BIND-1 report. Commun Biol. 2021;4 (1):903. doi: 10.1038/s42003-021-02421-6. PubMed PMID:34294869 .
  3. Ayyash, S, Davis, AD, Alders, GL, MacQueen, G, Strother, SC, Hassel, S et al.. Exploring brain connectivity changes in major depressive disorder using functional-structural data fusion: A CAN-BIND-1 study. Hum Brain Mapp. 2021; :. doi: 10.1002/hbm.25590. PubMed PMID:34296501 .
  4. Suh, JS, Fiori, LM, Ali, M, Harkness, KL, Ramonas, M, Minuzzi, L et al.. Hypothalamus volume and DNA methylation of stress axis genes in major depressive disorder: A CAN-BIND study report. Psychoneuroendocrinology. 2021;132 :105348. doi: 10.1016/j.psyneuen.2021.105348. PubMed PMID:34229186 .
  5. Papageorghiou, AT, Deruelle, P, Gunier, RB, Rauch, S, García-May, PK, Mhatre, M et al.. Preeclampsia and COVID-19: results from the INTERCOVID prospective longitudinal study. Am J Obstet Gynecol. 2021; :. doi: 10.1016/j.ajog.2021.05.014. PubMed PMID:34187688 PubMed Central PMC8233533.
  6. Nunez, JJ, Nguyen, TT, Zhou, Y, Cao, B, Ng, RT, Chen, J et al.. Replication of machine learning methods to predict treatment outcome with antidepressant medications in patients with major depressive disorder from STAR*D and CAN-BIND-1. PLoS One. 2021;16 (6):e0253023. doi: 10.1371/journal.pone.0253023. PubMed PMID:34181661 PubMed Central PMC8238228.
  7. Pandi-Perumal, SR, Vaccarino, SR, Chattu, VK, Zaki, NFW, BaHammam, AS, Manzar, D et al.. 'Distant socializing,' not 'social distancing' as a public health strategy for COVID-19. Pathog Glob Health. 2021; :1-8. doi: 10.1080/20477724.2021.1930713. PubMed PMID:34057046 .
  8. Allen, TA, Harkness, KL, Lam, RW, Milev, R, Frey, BN, Mueller, DJ et al.. Interactions between neuroticism and stressful life events predict response to pharmacotherapy for major depression: A CAN-BIND 1 report. Personal Ment Health. 2021; :. doi: 10.1002/pmh.1514. PubMed PMID:34008342 .
  9. Kennedy, SH, Dherange, BD, Berger, KJ, Levin, MD. Skeletal editing through direct nitrogen deletion of secondary amines. Nature. 2021;593 (7858):223-227. doi: 10.1038/s41586-021-03448-9. PubMed PMID:33981048 .
  10. Shakeel, MK, Hassel, S, Davis, AD, Metzak, PD, MacQueen, GM, Arnott, SR et al.. White matter microstructure in youth at risk for serious mental illness: A comparative analysis. Psychiatry Res Neuroimaging. 2021;312 :111289. doi: 10.1016/j.pscychresns.2021.111289. PubMed PMID:33910139 .
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Affiliations & Other Activities

  • Staff Physician, Department of Mental Health, St. Michael’s Hospital
  • Professor, Department of Psychiatry, University of Toronto
  • Research Scientist, Krembil Neurosciences, University Health Network