Sidney Kennedy



Research Programs


Sidney H. Kennedy is Professor of Psychiatry and Arthur Sommer Rotenberg Chair in Depression and Suicide Studies at the University of Toronto, Director of the Centre for Suicide and Depression Studies at St. Michael’s Hospital, and a Scientist at Li Ka Shing Knowledge Institute and Krembil Research Institute in Toronto. Dr. Kennedy is the lead investigator for the Canadian Biomarker Integration Network in Depression (CAN-BIND), a national depression biomarker initiative. He has published extensively on new drug evaluation, neuroimaging and neurostimulation therapies, personality factors in depression, antidepressant effects on sexual function, and treatment guidelines for Major Depressive Disorder and Bipolar Disorder.

Dr. Kennedy is the Immediate Past President of the International Society for Affective Disorders, former President of the Canadian College of Neuropsychopharmacology, and the founding chair of the Canadian Network for Mood and Anxiety Treatments (CANMAT).

Dr. Kennedy has authored close to 500 peer-reviewed publications and 11 books on depression and related topics. He is a Fellow of the Canadian Academy of Health Sciences and the Royal Society of Canada.

Recent Publications

  1. Yatham, LN, Chakrabarty, T, Bond, DJ, Schaffer, A, Beaulieu, S, Parikh, SV et al.. Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) recommendations for the management of patients with bipolar disorder with mixed presentations. Bipolar Disord. 2021; :. doi: 10.1111/bdi.13135. PubMed PMID:34599629 .
  2. Blumberger, DM, Vila-Rodriguez, F, Wang, W, Knyahnytska, Y, Butterfield, M, Noda, Y et al.. A randomized sham controlled comparison of once vs twice-daily intermittent theta burst stimulation in depression: A Canadian rTMS treatment and biomarker network in depression (CARTBIND) study. Brain Stimul. 2021;14 (6):1447-1455. doi: 10.1016/j.brs.2021.09.003. PubMed PMID:34560319 .
  3. Demchenko, I, Blumberger, DM, Flint, AJ, Anderson, M, Daskalakis, ZJ, Foley, K et al.. Electroconvulsive Therapy in Canada During the First Wave of COVID-19: Results of the "What Happened" National Survey. J ECT. 2021; :. doi: 10.1097/YCT.0000000000000801. PubMed PMID:34519681 .
  4. Monangi, N, Xu, H, Khanam, R, Khan, W, Deb, S, Pervin, J et al.. Association of maternal prenatal selenium concentration and preterm birth: a multicountry meta-analysis. BMJ Glob Health. 2021;6 (9):. doi: 10.1136/bmjgh-2021-005856. PubMed PMID:34518202 PubMed Central PMC8438754.
  5. Ballester, PL, Romano, MT, de Azevedo Cardoso, T, Hassel, S, Strother, SC, Kennedy, SH et al.. Brain age in mood and psychotic disorders: a systematic review and meta-analysis. Acta Psychiatr Scand. 2021; :. doi: 10.1111/acps.13371. PubMed PMID:34510423 .
  6. Yrondi, A, Fiori, LM, Nogovitsyn, N, Hassel, S, Théroux, JF, Aouabed, Z et al.. Association between the expression of lncRNA BASP-AS1 and volume of right hippocampal tail moderated by episode duration in major depressive disorder: a CAN-BIND 1 report. Transl Psychiatry. 2021;11 (1):469. doi: 10.1038/s41398-021-01592-4. PubMed PMID:34508068 PubMed Central PMC8433329.
  7. Elias, GJB, Boutet, A, Parmar, R, Wong, EHY, Germann, J, Loh, A et al.. Neuromodulatory treatments for psychiatric disease: A comprehensive survey of the clinical trial landscape. Brain Stimul. ;14 (5):1393-1403. doi: 10.1016/j.brs.2021.08.021. PubMed PMID:34461326 .
  8. Tapmeier, TT, Rahmioglu, N, Lin, J, De Leo, B, Obendorf, M, Raveendran, M et al.. Neuropeptide S receptor 1 is a nonhormonal treatment target in endometriosis. Sci Transl Med. 2021;13 (608):. doi: 10.1126/scitranslmed.abd6469. PubMed PMID:34433639 .
  9. Fiori, LM, Orri, M, Aouabed, Z, Théroux, JF, Lin, R, Nagy, C et al.. Treatment-emergent and trajectory-based peripheral gene expression markers of antidepressant response. Transl Psychiatry. 2021;11 (1):439. doi: 10.1038/s41398-021-01564-8. PubMed PMID:34420030 PubMed Central PMC8380246.
  10. Jones, BDM, Levitan, RD, Wang, W, Uher, R, Rotzinger, S, Foster, JA et al.. Metabolic variables associated with response to cognitive behavioural therapy for depression in females: A Canadian biomarker integration network for depression (CAN-BIND) study. J Psychiatr Res. 2021;142 :321-327. doi: 10.1016/j.jpsychires.2021.07.031. PubMed PMID:34419752 .
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Affiliations & Other Activities

  • Staff Physician, Department of Mental Health, St. Michael’s Hospital
  • Professor, Department of Psychiatry, University of Toronto
  • Research Scientist, Krembil Neurosciences, University Health Network