Sidney Kennedy



Research Programs


Sidney H. Kennedy is Professor of Psychiatry and Arthur Sommer Rotenberg Chair in Depression and Suicide Studies at the University of Toronto, Director of the Centre for Suicide and Depression Studies at St. Michael’s Hospital, and a Scientist at Li Ka Shing Knowledge Institute and Krembil Research Institute in Toronto. Dr. Kennedy is the lead investigator for the Canadian Biomarker Integration Network in Depression (CAN-BIND), a national depression biomarker initiative. He has published extensively on new drug evaluation, neuroimaging and neurostimulation therapies, personality factors in depression, antidepressant effects on sexual function, and treatment guidelines for Major Depressive Disorder and Bipolar Disorder.

Dr. Kennedy is the Immediate Past President of the International Society for Affective Disorders, former President of the Canadian College of Neuropsychopharmacology, and the founding chair of the Canadian Network for Mood and Anxiety Treatments (CANMAT).

Dr. Kennedy has authored close to 500 peer-reviewed publications and 11 books on depression and related topics. He is a Fellow of the Canadian Academy of Health Sciences and the Royal Society of Canada.

Recent Publications

  1. Shakeel, MK, Hassel, S, Davis, AD, Metzak, PD, MacQueen, GM, Arnott, SR et al.. White matter microstructure in youth at risk for serious mental illness: A comparative analysis. Psychiatry Res Neuroimaging. 2021;312 :111289. doi: 10.1016/j.pscychresns.2021.111289. PubMed PMID:33910139 .
  2. Green, LJ, Kennedy, SH, Mackillop, L, Gerry, S, Purwar, M, Staines Urias, E et al.. International gestational age-specific centiles for blood pressure in pregnancy from the INTERGROWTH-21st Project in 8 countries: A longitudinal cohort study. PLoS Med. 2021;18 (4):e1003611. doi: 10.1371/journal.pmed.1003611. PubMed PMID:33905424 .
  3. Villar, J, Ariff, S, Gunier, RB, Thiruvengadam, R, Rauch, S, Kholin, A et al.. Maternal and Neonatal Morbidity and Mortality Among Pregnant Women With and Without COVID-19 Infection: The INTERCOVID Multinational Cohort Study. JAMA Pediatr. 2021; :. doi: 10.1001/jamapediatrics.2021.1050. PubMed PMID:33885740 PubMed Central PMC8063132.
  4. Morton, E, Bhat, V, Giacobbe, P, Lou, W, Michalak, EE, McInerney, S et al.. Predictors of Quality of Life Improvement with Escitalopram and Adjunctive Aripiprazole in Patients with Major Depressive Disorder: A CAN-BIND Study Report. CNS Drugs. 2021;35 (4):439-450. doi: 10.1007/s40263-021-00803-2. PubMed PMID:33860922 .
  5. Villar, J, Gunier, RB, Tshivuila-Matala, COO, Rauch, SA, Nosten, F, Ochieng, R et al.. Fetal cranial growth trajectories are associated with growth and neurodevelopment at 2 years of age: INTERBIO-21st Fetal Study. Nat Med. 2021;27 (4):647-652. doi: 10.1038/s41591-021-01280-2. PubMed PMID:33737749 .
  6. Theyers, AE, Zamyadi, M, O'Reilly, M, Bartha, R, Symons, S, MacQueen, GM et al.. Multisite Comparison of MRI Defacing Software Across Multiple Cohorts. Front Psychiatry. 2021;12 :617997. doi: 10.3389/fpsyt.2021.617997. PubMed PMID:33716819 PubMed Central PMC7943842.
  7. Chakrabarty, T, McInerney, SJ, Torres, IJ, Frey, BN, Milev, RV, Müller, DJ et al.. Cognitive Outcomes with Sequential Escitalopram Monotherapy and Adjunctive Aripiprazole Treatment in Major Depressive Disorder: A Canadian Biomarker Integration Network in Depression (CAN-BIND-1) Report. CNS Drugs. 2021;35 (3):291-304. doi: 10.1007/s40263-021-00793-1. PubMed PMID:33683582 .
  8. Morton, E, Bhat, V, Giacobbe, P, Lou, W, Michalak, EE, Chakrabarty, T et al.. Impacts on Quality of Life with Escitalopram Monotherapy and Aripiprazole Augmentation in Patients with Major Depressive Disorder: A CAN-BIND Report. Pharmacopsychiatry. 2021; :. doi: 10.1055/a-1385-0263. PubMed PMID:33652477 .
  9. Villar, J, Restrepo-Méndez, MC, McGready, R, Barros, FC, Victora, CG, Munim, S et al.. Association Between Preterm-Birth Phenotypes and Differential Morbidity, Growth, and Neurodevelopment at Age 2 Years: Results From the INTERBIO-21st Newborn Study. JAMA Pediatr. 2021;175 (5):483-493. doi: 10.1001/jamapediatrics.2020.6087. PubMed PMID:33646288 PubMed Central PMC7922239.
  10. Marshe, VS, Maciukiewicz, M, Hauschild, AC, Islam, F, Qin, L, Tiwari, AK et al.. Genome-wide analysis suggests the importance of vascular processes and neuroinflammation in late-life antidepressant response. Transl Psychiatry. 2021;11 (1):127. doi: 10.1038/s41398-021-01248-3. PubMed PMID:33589590 PubMed Central PMC7884410.
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Affiliations & Other Activities

  • Staff Physician, Department of Mental Health, St. Michael’s Hospital
  • Professor, Department of Psychiatry, University of Toronto
  • Research Scientist, Krembil Neurosciences, University Health Network