Sidney Kennedy



Research Programs


Sidney H. Kennedy is Professor of Psychiatry and Arthur Sommer Rotenberg Chair in Depression and Suicide Studies at the University of Toronto, Director of the Centre for Suicide and Depression Studies at St. Michael’s Hospital, and a Scientist at Li Ka Shing Knowledge Institute and Krembil Research Institute in Toronto. Dr. Kennedy is the lead investigator for the Canadian Biomarker Integration Network in Depression (CAN-BIND), a national depression biomarker initiative. He has published extensively on new drug evaluation, neuroimaging and neurostimulation therapies, personality factors in depression, antidepressant effects on sexual function, and treatment guidelines for Major Depressive Disorder and Bipolar Disorder.

Dr. Kennedy is the Immediate Past President of the International Society for Affective Disorders, former President of the Canadian College of Neuropsychopharmacology, and the founding chair of the Canadian Network for Mood and Anxiety Treatments (CANMAT).

Dr. Kennedy has authored close to 500 peer-reviewed publications and 11 books on depression and related topics. He is a Fellow of the Canadian Academy of Health Sciences and the Royal Society of Canada.

Recent Publications

  1. Sajjadian, M, Lam, RW, Milev, R, Rotzinger, S, Frey, BN, Soares, CN et al.. Machine learning in the prediction of depression treatment outcomes: a systematic review and meta-analysis. Psychol Med. 2021;51 (16):2742-2751. doi: 10.1017/S0033291721003871. PubMed PMID:35575607 .
  2. Elsaid, S, Rubin-Kahana, DS, Kloiber, S, Kennedy, SH, Chavez, S, Le Foll, B et al.. Neurochemical Alterations in Social Anxiety Disorder (SAD): A Systematic Review of Proton Magnetic Resonance Spectroscopic Studies. Int J Mol Sci. 2022;23 (9):. doi: 10.3390/ijms23094754. PubMed PMID:35563145 PubMed Central PMC9105768.
  3. Espinola, CW, Khoo, Y, Parmar, R, Demchenko, I, Frey, BN, Milev, RV et al.. Males and females differ in reported sexual functioning with escitalopram treatment for major depressive disorder: A CAN-BIND-1 study report. J Psychopharmacol. 2022;36 (5):604-613. doi: 10.1177/02698811221095832. PubMed PMID:35546043 .
  4. Frenquelli, R, Ratcliff, M, Villar de Onis, J, Fernandes, M, Barros, FC, Hirst, JE et al.. Complex Perinatal Syndromes Affecting Early Human Growth and Development: Issues to Consider to Understand Their Aetiology and Postnatal Effects. Front Neurosci. 2022;16 :856886. doi: 10.3389/fnins.2022.856886. PubMed PMID:35509448 PubMed Central PMC9058100.
  5. Diep, C, Rosenek, N, Khoo, Y, Gandhi, W, van Reekum, CM, Ravindran, AV et al.. Pain severity and pain interference during major depressive episodes treated with escitalopram and aripiprazole adjunctive therapy: a CAN-BIND-1 report. Psychiatry Res. 2022;312 :114557. doi: 10.1016/j.psychres.2022.114557. PubMed PMID:35461118 .
  6. Giuliani, F, Oros, D, Gunier, RB, Deantoni, S, Rauch, S, Casale, R et al.. Effects of prenatal exposure to maternal COVID-19 and perinatal care on neonatal outcome: results from the INTERCOVID Multinational Cohort Study. Am J Obstet Gynecol. 2022; :. doi: 10.1016/j.ajog.2022.04.019. PubMed PMID:35452653 PubMed Central PMC9017081.
  7. Mosabbir, AA, Braun Janzen, T, Al Shirawi, M, Rotzinger, S, Kennedy, SH, Farzan, F et al.. Investigating the Effects of Auditory and Vibrotactile Rhythmic Sensory Stimulation on Depression: An EEG Pilot Study. Cureus. 2022;14 (2):e22557. doi: 10.7759/cureus.22557. PubMed PMID:35371676 PubMed Central PMC8958118.
  8. Liu, H, Kerzner, J, Demchenko, I, Wijeysundera, DN, Kennedy, SH, Ladha, KS et al.. Nitrous oxide for the treatment of psychiatric disorders: A systematic review of the clinical trial landscape. Acta Psychiatr Scand. 2022; :. doi: 10.1111/acps.13432. PubMed PMID:35353901 .
  9. Espinola, CW, Khoo, Y, Parmar, R, Demchenko, I, Frey, BN, Milev, RV et al.. Pretreatment anxious depression as a predictor of side effect frequency and severity in escitalopram and aripiprazole adjunctive therapy. Brain Behav. 2022; :e2555. doi: 10.1002/brb3.2555. PubMed PMID:35333448 .
  10. Magee, LA, Benetou, V, George-Carey, R, Kulkarni, J, MacDermott, NE, Missmer, SA et al.. Editorial: COVID-19 and Women's Health. Front Glob Womens Health. 2022;3 :861315. doi: 10.3389/fgwh.2022.861315. PubMed PMID:35309151 PubMed Central PMC8927876.
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Affiliations & Other Activities

  • Staff Physician, Department of Mental Health, St. Michael’s Hospital
  • Professor, Department of Psychiatry, University of Toronto
  • Research Scientist, Krembil Neurosciences, University Health Network