Wolfgang Kuebler


Affiliate Scientist

Research Programs


Wolfgang Kuebler Lab ❯


Please note Dr. Kuebler will not be accepting summer students.

Dr. Wolfgang Kuebler is an Associate Scientist at the Keenan Research Centre for Biomedical Science of St. Michael’s Hospital. He is a Professor at the University of Toronto in both the Department of Surgery and the Department of Physiology and a Professor of Physiology at the Charité-Universitaetsmedizin Berlin with an endowed professorship by the German Heart Institute Berlin. He is also an Adjunct Professor in the Department of Electrical and Computer Engineering at Ryerson University, and an Adjunct Professor in the College of Graduate Studies and Research at the University of Saskatchewan.

His research interest focuses on translational research in pulmonary and microvascular physiology and pathophysiology, he has published > 120 peer-reviewed articles largely on topics that integrate basic research on intracellular signalling and intercellular communication pathways to the level of the intact organ and organism in complex disease models such as acute lung injury, lung edema, or pulmonary hypertension. A special methodological focus of his work is the use of intravital microscopy and real-time fluorescence imaging techniques in intact organs or life animal models, which he combines with both cell and molecular biology techniques as well as physiological measurements.

He currently serves as Chair of the Section Advisory Committee and as Past-Chair of the Respiration Section for the American Physiological Society. In addition, he is the Chair of the Scientific Advisory Panel for the Ludwig-Boltzmann-Institute for Lung Vascular Research in Graz, Austria, and as Associate Editor for the American Journal of Physiology – Lung Cellular and Molecular Physiology and for Experimental Lung Research. He has served on numerous review panels for Canadian Institutes of Health Research and the Heart & Stroke Foundation, and as ad-hoc reviewer for funding agencies in Canada, UK, Ireland, France, Germany, Austria, Israel, Italy, Poland, and Hungary.

Recent Publications

  1. Böning, D, Kuebler, WM, Bloch, W. The Oxygen Dissociation Curve of Blood in COVID-19. Am J Physiol Lung Cell Mol Physiol. 2021; :. doi: 10.1152/ajplung.00079.2021. PubMed PMID:33978488 .
  2. Zhang, J, Guo, JR, Huang, ZS, Fu, WL, Wu, XL, Wu, N et al.. Transbronchial mediastinal cryobiopsy in the diagnosis of mediastinal lesions: a randomised trial. Eur Respir J. 2021; :. doi: 10.1183/13993003.00055-2021. PubMed PMID:33958432 .
  3. Behrens, F, Funk-Hilsdorf, TC, Kuebler, WM, Simmons, S. Bacterial Membrane Vesicles in Pneumonia: From Mediators of Virulence to Innovative Vaccine Candidates. Int J Mol Sci. 2021;22 (8):. doi: 10.3390/ijms22083858. PubMed PMID:33917862 PubMed Central PMC8068278.
  4. Ott, C, Jung, T, Brix, S, John, C, Betz, IR, Foryst-Ludwig, A et al.. Hypertrophy-Reduced Autophagy Causes Cardiac Dysfunction by Directly Impacting Cardiomyocyte Contractility. Cells. 2021;10 (4):. doi: 10.3390/cells10040805. PubMed PMID:33916597 PubMed Central PMC8065800.
  5. Masterson, CH, Tabuchi, A, Hogan, G, Fitzpatrick, G, Kerrigan, SW, Jerkic, M et al.. Intra-vital imaging of mesenchymal stromal cell kinetics in the pulmonary vasculature during infection. Sci Rep. 2021;11 (1):5265. doi: 10.1038/s41598-021-83894-7. PubMed PMID:33664277 PubMed Central PMC7933415.
  6. Witzenrath, M, Kuebler, WM. Connecting the dots: the role of connexins in the pulmonary vascular response to hypoxia. Eur Respir J. 2021;57 (3):. doi: 10.1183/13993003.04573-2020. PubMed PMID:33664100 .
  7. Brandt, R, Timm, S, Gorenflos López, JL, Kwame Abledu, J, Kuebler, WM, Hackenberger, CPR et al.. Metabolic Glycoengineering Enables the Ultrastructural Visualization of Sialic Acids in the Glycocalyx of the Alveolar Epithelial Cell Line hAELVi. Front Bioeng Biotechnol. 2020;8 :614357. doi: 10.3389/fbioe.2020.614357. PubMed PMID:33520965 PubMed Central PMC7841390.
  8. Weidenfeld, S, Chupin, C, Langner, DI, Zetoun, T, Rozowsky, S, Kuebler, WM et al.. Sodium-coupled neutral amino acid transporter SNAT2 counteracts cardiogenic pulmonary edema by driving alveolar fluid clearance. Am J Physiol Lung Cell Mol Physiol. 2021;320 (4):L486-L497. doi: 10.1152/ajplung.00461.2020. PubMed PMID:33439101 .
  9. Abdel Hameid, R, Cormet-Boyaka, E, Kuebler, WM, Uddin, M, Berdiev, BK. SARS-CoV-2 may hijack GPCR signaling pathways to dysregulate lung ion and fluid transport. Am J Physiol Lung Cell Mol Physiol. 2021;320 (3):L430-L435. doi: 10.1152/ajplung.00499.2020. PubMed PMID:33434105 PubMed Central PMC7938641.
  10. Behrens, F, Holle, J, Kuebler, WM, Simmons, S. Extracellular vesicles as regulators of kidney function and disease. Intensive Care Med Exp. 2020;8 (Suppl 1):22. doi: 10.1186/s40635-020-00306-2. PubMed PMID:33336297 PubMed Central PMC7746786.
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Affiliations & Other Activities


  • Member, Institute for Biomedical Engineering and Science Technology (iBEST) at Ryerson University and St. Michael’s Hospital
  • Professor, Department of Surgery, University of Toronto
  • Professor, Department of Physiology, University of Toronto
  • Full Member, Institute of Medical Sciences Graduate School, University of Toronto
  • Member, Heart & Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research, University of Toronto
  • Professor, Institut of Physiology at the Charité-Universitaetsmedizin Berlin, endowed by the German Heart Institute Berlin
  • Adjunct Professor, Department of Electrical and Computer Engineering, Ryerson University
  • Adjunct Professor, College of Graduate Studies and Research, University of Saskatchewan