Wolfgang Kuebler


Affiliate Scientist

Research Programs


Wolfgang Kuebler Lab ❯


Please note Dr. Kuebler will not be accepting summer students.

Dr. Wolfgang Kuebler is an Associate Scientist at the Keenan Research Centre for Biomedical Science of St. Michael’s Hospital. He is a Professor at the University of Toronto in both the Department of Surgery and the Department of Physiology and a Professor of Physiology at the Charité-Universitaetsmedizin Berlin with an endowed professorship by the German Heart Institute Berlin. He is also an Adjunct Professor in the Department of Electrical and Computer Engineering at Ryerson University, and an Adjunct Professor in the College of Graduate Studies and Research at the University of Saskatchewan.

His research interest focuses on translational research in pulmonary and microvascular physiology and pathophysiology, he has published > 120 peer-reviewed articles largely on topics that integrate basic research on intracellular signalling and intercellular communication pathways to the level of the intact organ and organism in complex disease models such as acute lung injury, lung edema, or pulmonary hypertension. A special methodological focus of his work is the use of intravital microscopy and real-time fluorescence imaging techniques in intact organs or life animal models, which he combines with both cell and molecular biology techniques as well as physiological measurements.

He currently serves as Chair of the Section Advisory Committee and as Past-Chair of the Respiration Section for the American Physiological Society. In addition, he is the Chair of the Scientific Advisory Panel for the Ludwig-Boltzmann-Institute for Lung Vascular Research in Graz, Austria, and as Associate Editor for the American Journal of Physiology – Lung Cellular and Molecular Physiology and for Experimental Lung Research. He has served on numerous review panels for Canadian Institutes of Health Research and the Heart & Stroke Foundation, and as ad-hoc reviewer for funding agencies in Canada, UK, Ireland, France, Germany, Austria, Israel, Italy, Poland, and Hungary.

Recent Publications

  1. Böning, D, Bloch, W, Kuebler, WM. Reply to Vogel et al. Am J Physiol Lung Cell Mol Physiol. 2021;321 (3):L638-L639. doi: 10.1152/ajplung.00327.2021. PubMed PMID:34491860 PubMed Central PMC8435939.
  2. Nassir, N, Tambi, R, Bankapur, A, Al Heialy, S, Karuvantevida, N, Khansaheb, HH et al.. Single-cell transcriptome identifies FCGR3B upregulated subtype of alveolar macrophages in patients with critical COVID-19. iScience. 2021;24 (9):103030. doi: 10.1016/j.isci.2021.103030. PubMed PMID:34458692 PubMed Central PMC8384759.
  3. Zergane, M, Kuebler, WM, Michalick, L. Heteromeric TRP Channels in Lung Inflammation. Cells. 2021;10 (7):. doi: 10.3390/cells10071654. PubMed PMID:34359824 PubMed Central PMC8307017.
  4. Ehrlich, K, Wilhelm, J, Markart, P, Weisser, H, Wolff, JC, Bein, G et al.. Sex-specific differences in plasma levels of FXII, HK, and FXIIa-C1-esterase inhibitor complexes in community acquired pneumonia. Am J Physiol Lung Cell Mol Physiol. 2021; :. doi: 10.1152/ajplung.00162.2021. PubMed PMID:34318685 .
  5. Abdel Hameid, R, Cormet-Boyaka, E, Kuebler, WM, Uddin, M, Berdiev, BK. Reply to Eisenhut. Am J Physiol Lung Cell Mol Physiol. 2021;321 (1):L287-L289. doi: 10.1152/ajplung.00246.2021. PubMed PMID:34233142 PubMed Central PMC8270517.
  6. Witzenrath, M, Kuebler, WM. The Lung-brain Axis in Ventilator-induced Brain Injury- Enter Interleukin-6. Am J Respir Cell Mol Biol. 2021; :. doi: 10.1165/rcmb.2021-0233ED. PubMed PMID:34153209 .
  7. Shimoda, LA, Bai, C, Bartlett, NW, Bastarache, JA, Feghali-Bostwick, C, Kuebler, WM et al.. Announcing the Editorial Board Fellowship Program of the American Journal of Physiology-Lung Cellular and Molecular Physiology. Am J Physiol Lung Cell Mol Physiol. 2021;321 (1):L116-L118. doi: 10.1152/ajplung.00239.2021. PubMed PMID:34105373 PubMed Central PMC8321860.
  8. Witzenrath, M, Kuebler, WM. The CypA-netics of Ventilator-induced Lung Injury. Am J Respir Crit Care Med. 2021;204 (4):385-387. doi: 10.1164/rccm.202104-0919ED. PubMed PMID:34033522 .
  9. Elieh Ali Komi, D, Kuebler, WM. Significance of Mast Cell Formed Extracellular Traps in Microbial Defense. Clin Rev Allergy Immunol. 2021; :. doi: 10.1007/s12016-021-08861-6. PubMed PMID:34024033 PubMed Central PMC8140557.
  10. Lerchbaumer, MH, Lauryn, JH, Bachmann, U, Enghard, P, Fischer, T, Grune, J et al.. Point-of-care lung ultrasound in COVID-19 patients: inter- and intra-observer agreement in a prospective observational study. Sci Rep. 2021;11 (1):10678. doi: 10.1038/s41598-021-90153-2. PubMed PMID:34021219 PubMed Central PMC8139973.
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Affiliations & Other Activities


  • Member, Institute for Biomedical Engineering and Science Technology (iBEST) at Ryerson University and St. Michael’s Hospital
  • Professor, Department of Surgery, University of Toronto
  • Professor, Department of Physiology, University of Toronto
  • Full Member, Institute of Medical Sciences Graduate School, University of Toronto
  • Member, Heart & Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research, University of Toronto
  • Professor, Institut of Physiology at the Charité-Universitaetsmedizin Berlin, endowed by the German Heart Institute Berlin
  • Adjunct Professor, Department of Electrical and Computer Engineering, Ryerson University
  • Adjunct Professor, College of Graduate Studies and Research, University of Saskatchewan